A repeating amino acid motif shared by proteins with diverse cellular roles

scientific article (publication date: 11 March 1994)

A repeating amino acid motif shared by proteins with diverse cellular roles is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0092-8674(94)90353-0
P698PubMed publication ID7907279
P5875ResearchGate publication ID15292511

P50authorMark PeiferQ30323425
P2093author name stringA B Reynolds
S Berg
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)789-91
P577publication date1994-03-11
P1433published inCellQ655814
P1476titleA repeating amino acid motif shared by proteins with diverse cellular roles
P478volume76

Reverse relations

cites work (P2860)
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Q42158948Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli
Q28279006Desmosomal cadherin binding domains of plakoglobin
Q33417634Detection of alpha-rod protein repeats using a neural network and application to huntingtin.
Q35953120Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides
Q39965303Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney
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Q28575660Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization
Q34771575Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
Q52551617Drosophila alpha-catenin and E-cadherin bind to distinct regions of Drosophila Armadillo.
Q34615049Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis
Q35832252Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry
Q42496449Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking
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Q34321680E-cadherin complex and its abnormalities in human breast cancer
Q22011153EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue
Q24298765ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells
Q84394197Early senescence and cell death in Arabidopsis saul1 mutants involves the PAD4-dependent salicylic acid pathway
Q36235397Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling
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Q30043052Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodium falciparum Armadillo Repeat Containing Protein
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Q89072776Genome-wide identification and expression analysis of the BTB domain-containing protein gene family in tomato
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Q33506411Highly sensitive detection of individual HEAT and ARM repeats with HHpred and COACH
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Q35875570IGF-I receptor, cell-cell adhesion, tumour development and progression
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Q24317401Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein
Q24320344Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family
Q42642928Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome
Q24328774Identification of Plakoglobin Domains Required for Association with N-cadherin and α-Catenin
Q40802423Identification of Src phosphorylation sites in the catenin p120ctn
Q28205508Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal
Q36672550Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes
Q24317602Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome
Q42022296Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells
Q28215785Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4
Q36919553Identification of darlin, a Dictyostelium protein with Armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells
Q39899894Identification of extracellular delta-catenin accumulation for prostate cancer detection
Q22254750Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
Q48042494Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression
Q22008557Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A
Q24541320Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules
Q74236761Importin alpha binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I
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Q41069591Intermediate filament organization, reorganization, and function in the clawed frog Xenopus
Q41930100Intestinal HT-29 cells with dysfunction of E-cadherin show increased pp60src activity and tyrosine phosphorylation of p120-catenin
Q34594105Intrinsic disorder in scaffold proteins: getting more from less
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Q29568904Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors
Q44059623LFR, which encodes a novel nuclear-localized Armadillo-repeat protein, affects multiple developmental processes in the aerial organs in Arabidopsis
Q41477999LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells
Q39809313Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression
Q36812590Looking beyond the Wnt pathway for the deep nature of β-catenin.
Q77973966Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival
Q22065647Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export
Q46505463Metazoan evolution of the armadillo repeat superfamily.
Q47202039MicroRNA-128 suppresses paclitaxel-resistant lung cancer by inhibiting MUC1-C and BMI-1 in cancer stem cells.
Q36760938Molecular basis of sperm flagellar axonemes: structural and evolutionary aspects
Q44941597Molecular characterization of an elicitor-responsive Armadillo repeat gene (GhARM) from cotton (Gossypium hirsutum).
Q24292940Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations
Q24535907Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
Q36650529Multifunctional arm repeat domains in plants
Q30418378Mutations in the APC gene and their implications for protein structure and function
Q36890733N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteins
Q28345992ND9P, a novel protein with armadillo-like repeats involved in exocytosis: physiological studies using allelic mutants in paramecium
Q28306037NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein
Q40525111Not just glue: cell-cell junctions as cellular signaling centers
Q51839904Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
Q34049354Nuclear Rac1 regulates the bFGF-induced neurite outgrowth in PC12 cells
Q77903798Nuclear import and export of proteins: the molecular basis for intracellular signaling
Q48061619Nuclear import in permeabilized protoplasts from higher plants has unique features
Q77795993Nuclear import: a tale of two sites
Q39551576Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression
Q36593332Nuclear localization signal binding protein from Arabidopsis mediates nuclear import of Agrobacterium VirD2 protein
Q52532544Nuclear localization signal receptor importin alpha associates with the cytoskeleton.
Q28645531Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin
Q24633420Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2
Q36372013Nuclear transport is becoming crystal clear
Q35678324Nucleocytoplasmic shuttling of signal transducers.
Q34245364Nucleocytoplasmic transport enters the atomic age.
Q36574246Nucleocytoplasmic transport of macromolecules
Q40403309Nucleocytoplasmic transport: factors and mechanisms
Q34649562Origin and evolution of protein fold designs inferred from phylogenomic analysis of CATH domain structures in proteomes
Q41384166Our evolving view of Wnt signaling in C. elegans: If two's company and three's a crowd, is four really necessary?
Q39238903P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model
Q39968378P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells
Q36799647PF16 encodes a protein with armadillo repeats and localizes to a single microtubule of the central apparatus in Chlamydomonas flagella
Q34112783Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily
Q52111081Patterns of importin-alpha expression during Drosophila spermatogenesis.
Q36535709Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation
Q28139946Physical characterization of plakophilin 1 reconstituted with and without zinc
Q59099056Physiological and pathological functions of LRRK2: implications from substrate proteins
Q47073294Plakoglobin has both structural and signalling roles in zebrafish development
Q38347114Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.
Q41385824Plakoglobin: kinetics of synthesis, phosphorylation, stability, and interactions with desmoglein and E-cadherin
Q38857178Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression
Q22010141Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
Q24321281Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque
Q91734017Postoperative Development of Desmoid Tumor After Surgical Correction of Adult Spinal Deformity: Case Report and Review of Literature
Q33835683Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms
Q33918198Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy
Q41017143Protein import into the nucleus
Q27860694Protein modules and signalling networks
Q41109987Protein sequence motifs
Q33996974Protein-protein interactions in signaling cascades
Q36000726Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei
Q73089624Purification and characterization of guanine nucleotide dissociation stimulator protein
Q24316431RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1
Q28301171RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae
Q36119460Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors
Q24312782Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein
Q42467275Redistribution of the kinesin-II subunit KAP from cilia to nuclei during the mitotic and ciliogenic cycles in sea urchin embryos
Q47072126Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
Q36275000Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system
Q77582000Regulation of chondrocyte differentiation and maturation
Q37573407Regulation of endothelial barrier function by p120-catenin∙VE-cadherin interaction
Q35047240Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
Q50888768Restricted mobility of side chains on concave surfaces of solenoid proteins may impart heightened potential for intermolecular interactions.
Q27641651Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α
Q33440177Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle
Q48064951Role of the nuclear transport factor p10 in nuclear import
Q24318035SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase
Q30457060SRChing for the substrates of Src.
Q28276802Secondary structure of an armadillo single repeat from the APC protein
Q22008541Selection system for genes encoding nuclear-targeted proteins
Q24683255Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
Q50336589Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport.
Q24298530Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis
Q24530639Signal transduction by the Wnt family of ligands
Q38362658Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin
Q34752099SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.
Q34284968Splice variants of SmgGDS control small GTPase prenylation and membrane localization
Q48172461Spotted leaf11, a negative regulator of plant cell death and defense, encodes a U-box/armadillo repeat protein endowed with E3 ubiquitin ligase activity
Q90080035Structural Insights into the Regulation Mechanism of Small GTPases by GEFs
Q37687100Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97.
Q27618579Structural view of the Ran-Importin beta interaction at 2.3 A resolution
Q27639992Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
Q27678805Structure-based optimization of designed Armadillo-repeat proteins
Q47943507Structures of designed armadillo repeat proteins binding to peptides fused to globular domains
Q41462860Studies of neoplasia in the Min mouse
Q37626011Synchronization by Daytime Restricted Food Access Modulates the Presence and Subcellular Distribution of β-Catenin and Its Phosphorylated Forms in the Rat Liver.
Q35007386Tandem-repeat protein domains across the tree of life
Q28293128Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Q52055454Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo.
Q24642163Terminal regions of beta-catenin come into view
Q24317231The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
Q36246621The Arabidopsis paralogs, PUB46 and PUB48, encoding U-box E3 ubiquitin ligases, are essential for plant response to drought stress
Q27319513The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes
Q41967300The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
Q36323071The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis
Q38987962The Central Apparatus of Cilia and Eukaryotic Flagella
Q39478458The F-box family genes as key elements in response to salt, heavy mental, and drought stresses in Medicago truncatula.
Q29042060The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts
Q27664689The Transcription Factor Spn1 Regulates Gene Expression via a Highly Conserved Novel Structural Motif
Q24651394The Tyrosine Kinase Substrate p120cas Binds Directly to E-Cadherin but Not to the Adenomatous Polyposis Coli Protein or α-Catenin
Q34192072The Wnt signaling pathway and its role in tumor development
Q30427620The adenomatous polyposis coli (APC) tumor suppressor
Q24676676The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes
Q52566182The armadillo family of structural proteins.
Q24647979The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10
Q36236694The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential
Q24612205The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence
Q33662501The catenin family at a glance
Q37622606The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.
Q24534469The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
Q27639186The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)
Q24320101The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors
Q35764201The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin
Q34838428The ins and outs of APC and beta-catenin nuclear transport
Q28278924The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins
Q36535718The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis
Q34486253The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
Q35566863The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
Q24308766The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
Q55057418The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance.
Q28281493The role of NUP98 gene fusions in hematologic malignancy
Q54343211The roles of intrinsic disorder in orchestrating the Wnt-pathway.
Q27685309The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family
Q51605857The transcriptional program of synchronous gametogenesis in Chlamydomonas reinhardtii.
Q88965519Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers
Q48279503Three distinct classes of the alpha-subunit of the nuclear pore-targeting complex (importin-alpha) are differentially expressed in adult mouse tissues
Q27743283Three-dimensional structure of the armadillo repeat region of beta-catenin
Q39870342Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells
Q28199033Topological characteristics of helical repeat proteins
Q41066972Toward the molecular dissection of protein import into nuclei
Q73318790Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency
Q33666869Turn up the HEAT.
Q24320769Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
Q24651552Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia
Q38285301UCS proteins: chaperones for myosin and co-chaperones for Hsp90.
Q88985377USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
Q35877061Unraveling the cytoplasmic interactions of the cadherin superfamily
Q27653959Unusual Armadillo Fold in the Human General Vesicular Transport Factor p115
Q41134314V(D)J recombination pathology.
Q28255695VE-cadherin: adhesion at arm's length
Q27930646Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole
Q34986007VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases
Q33922977When protein folding is simplified to protein coiling: the continuum of solenoid protein structures
Q35176032Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma
Q37342306Wnt signaling from development to disease: insights from model systems
Q24294443Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
Q28619032XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
Q30651588Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region
Q34329601Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity
Q35601669Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure
Q27932000Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
Q48038314bagpipe-Dependent expression of vimar, a novel Armadillo-repeats gene, in Drosophila visceral mesoderm
Q28640339beta-catenin can be transported into the nucleus in a Ran-unassisted manner
Q34432898beta-catenin: molecular plasticity and drug design.
Q22010559cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus
Q37139096delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Q24682785delta-catenin, an adhesive junction-associated protein which promotes cell scattering
Q28201248p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle
Q36324842p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions
Q33180846p120 catenin regulates the actin cytoskeleton via Rho family GTPases
Q40760969p120(cat) Delocalization in cell lines of oral cancer.
Q24684160p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
Q30442222p120, a p120-related protein (p100), and the cadherin/catenin complex
Q40195920p120-Catenin is required for mouse vascular development
Q38065309p120-Catenin: a novel regulator of innate immunity and inflammation
Q36686745p120-catenin: Past and present
Q34110803δ-Catenin dysregulation in cancer: interactions with E-cadherin and beyond
Q38895174δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity

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