p120 catenin regulates the actin cytoskeleton via Rho family GTPases

scientific article

p120 catenin regulates the actin cytoskeleton via Rho family GTPases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.150.3.567
P932PMC publication ID2175185
P698PubMed publication ID10931868
P5875ResearchGate publication ID25851876

P2093author name stringK Burridge
B Kreft
B P Liu
N K Noren
P2860cites workThe catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factorQ22009416
Presenilin 1 interaction in the brain with a novel member of the Armadillo familyQ24317257
Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndromeQ24317602
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene familyQ24320344
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeletonQ24336494
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2Q24533404
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrinsQ24551376
The uvomorulin-anchorage protein alpha catenin is a vinculin homologueQ24560521
Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expressionQ24644611
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epitheliaQ24651552
Regulation of cadherin adhesive activityQ24669932
Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-cateninQ24672506
delta-catenin, an adhesive junction-associated protein which promotes cell scatteringQ24682785
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctnQ24683225
Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesionQ24683255
Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localizationQ24683420
p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cellsQ24684160
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activityQ28139957
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-cateninQ28143737
A repeating amino acid motif shared by proteins with diverse cellular rolesQ28237358
A brain serine/threonine protein kinase activated by Cdc42 and Rac1Q28249559
Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cellsQ28255242
Cell adhesion: the molecular basis of tissue architecture and morphogenesisQ28276573
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesionQ28278750
The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblastsQ28281143
A novel regulator of p21-activated kinasesQ28281325
Identification of a mouse p21Cdc42/Rac activated kinaseQ28289355
Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complexQ28289996
Assembly of the cadherin-catenin complex in vitro with recombinant proteinsQ28299440
Vav2 is an activator of Cdc42, Rac1, and RhoAQ28610652
The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell ContactsQ29042060
Contact inhibition and malignancyQ29393421
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Morphogenetic roles of classic cadherinsQ29614941
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPasesQ29618793
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
Cadherin cell adhesion receptors as a morphogenetic regulatorQ29620503
Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav.Q30194945
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cellsQ30441876
p120, a p120-related protein (p100), and the cadherin/catenin complexQ30442222
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src geneQ30450407
p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadilloQ30799593
Cadherins and tissue formation: integrating adhesion and signalingQ33638694
Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.Q33744913
Cadherins and their connections: adhesion junctions have broader functions.Q33744981
ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexesQ33895129
Genetic and biochemical dissection of protein linkages in the cadherin-catenin complexQ34287597
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.Q34442292
Relation between cell activity and the distribution of cytoplasmic actin and myosinQ36204969
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signalingQ36235397
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarityQ36256216
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expressionQ36294742
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasisQ36316373
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acidQ36565713
Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context.Q36834868
Tyrosine phosphorylation and cadherin/catenin functionQ36890220
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cellsQ36945360
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cellsQ40021756
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasivenessQ40760011
Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviorQ40915141
Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptorQ41065014
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cellsQ41075647
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.Q41075804
Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases.Q41078111
Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.Q41118056
Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src.Q41127787
E-cadherin mediates adhesion and suppresses cell motility via distinct mechanismsQ41130170
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.Q41450596
Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cellsQ41660869
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor roleQ41674960
Molecular and functional analysis of cadherin-based adherens junctionsQ41689344
The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activityQ41997168
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.Q42125827
PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrateQ42622010
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cellsQ42796987
Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation.Q42832291
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cellsQ43107815
Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructureQ44031758
Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo.Q46328098
Dephosphorylation of the cadherin-associated p100/p120 proteins in response to activation of protein kinase C in epithelial cells.Q52528325
The p120 catenin family: complex roles in adhesion, signaling and cancer.Q53412239
Rac is required for growth cone function but not neurite assemblyQ73202490
Cytomechanics of cadherin-mediated cell-cell adhesionQ77565690
Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancerQ77565725
Focal adhesion assemblyQ80818360
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
actin cytoskeletonQ14860845
P304page(s)567-580
P577publication date2000-08-01
P1433published inJournal of Cell BiologyQ1524550
P1476titlep120 catenin regulates the actin cytoskeleton via Rho family GTPases
P478volume150

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Q73062603The crossroads between cell-cell adhesion and motility
Q36091824The function of p120 catenin in filopodial growth and synaptic vesicle clustering in neurons
Q34540405The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells
Q33786720The molecular evolution of the p120-catenin subfamily and its functional associations
Q38343288The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.
Q34682265The role of chalcones in suppression of NF-κB-mediated inflammation and cancer
Q28512337The transcriptional repressor Glis2 is a novel binding partner for p120 catenin
Q43810205Tissue distribution and cell type-specific expression of p120ctn isoforms
Q36567245Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
Q37406740To adhere or not to adhere: the role of Cadherins in neural crest development
Q34621022Turn-off, drop-out: functional state switching of cadherins
Q40625994Two regions of cadherin cytoplasmic domains are involved in suppressing motility of a mammary carcinoma cell line.
Q36580511Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin
Q24515256VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
Q48215842VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function
Q28255695VE-cadherin: adhesion at arm's length
Q40604719Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma
Q34360175Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.
Q36321975Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac.
Q90382654Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
Q35741011Working out the strength and flexibility of desmosomes
Q34329601Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity
Q26995346Xin proteins and intercalated disc maturation, signaling and diseases
Q41847064c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells
Q42362761miR-223 promotes colon cancer by directly targeting p120 catenin
Q39788653p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cells
Q36904676p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas
Q36111209p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification
Q36914258p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.
Q36324842p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions
Q40609842p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation
Q36972614p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression.
Q36118710p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness
Q28505956p120 catenin is required for normal renal tubulogenesis and glomerulogenesis
Q24654118p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins
Q30444077p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin
Q38088489p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.
Q34502037p120 regulates endothelial permeability independently of its NH2terminus and Rho binding
Q40239203p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation
Q51657544p120-Catenin modulating nuclear factor-κB activation is partially RhoA/ROCKdependent in scratch injury.
Q30483820p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation
Q38065309p120-Catenin: a novel regulator of innate immunity and inflammation
Q36680541p120-catenin and β-catenin differentially regulate cadherin adhesive function
Q36518604p120-catenin controls contractility along the vertical axis of epithelial lateral membranes
Q34407991p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals
Q38748421p120-catenin in canonical Wnt signaling
Q37146677p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism
Q36914270p120-catenin is a key component of the cadherin-gamma-secretase supercomplex
Q33882907p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice
Q30513454p120-catenin is essential for terminal end bud function and mammary morphogenesis
Q40164009p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.
Q24647606p120-catenin mediates inflammatory responses in the skin
Q30833306p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
Q36686745p120-catenin: Past and present
Q37204601p120catenin alteration in cancer and its role in tumour invasion.
Q27322852p120ctn and P-Cadherin but Not E-Cadherin Regulate Cell Motility and Invasion of DU145 Prostate Cancer Cells
Q28538995pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)
Q28543177δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases

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