P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

scientific article published on 24 January 2013

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.4143
P8608Fatcat IDrelease_qlswzixdmfgubolkaeahufjfki
P698PubMed publication ID23180380
P5875ResearchGate publication ID233770346

P50authorSara RicardoQ53231632
Ana S. RibeiroQ55711133
Nuno MendesQ58177849
Ana Rita NobreQ59086687
Bárbara SousaQ37382057
André AlbergariaQ37382123
Joana ParedesQ37382149
Fernando SchmittQ37382197
Raquel SerucaQ37829860
Ola SöderbergQ39977684
Manuel SantosQ42712782
P2093author name stringLaura Carreto
Rene Gerhard
Jorge F Cameselle-Teijeiro
P2860cites workThe Hallmarks of CancerQ221226
miR-200 enhances mouse breast cancer cell colonization to form distant metastasesQ21091183
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctnQ24683225
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
A repeating amino acid motif shared by proteins with diverse cellular rolesQ28237358
The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblastsQ28281143
Complex networks orchestrate epithelial-mesenchymal transitionsQ29547478
Regulation of cadherin-mediated adhesion in morphogenesisQ29614940
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
TGF-beta and epithelial-to-mesenchymal transitionsQ29616456
Cadherin cell adhesion receptors as a morphogenetic regulatorQ29620503
p120 catenin regulates the actin cytoskeleton via Rho family GTPasesQ33180846
Biophysical properties of cadherin bonds do not predict cell sortingQ33343541
Functional characterization of E- and P-cadherin in invasive breast cancer cellsQ33414412
Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor PhenotypeQ33742129
CDH3/P-Cadherin regulates migration of HuCCT1 cholangiocarcinoma cellsQ34389423
An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancerQ34433806
Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situQ34459652
Cadherins and the tumour progression: is it all in a switch?Q34502753
Similarities between heterophilic and homophilic cadherin adhesionQ35108263
Cell-cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the ruleQ35138072
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistanceQ35142784
Rho-regulatory proteins in breast cancer cell motility and invasionQ35681634
p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasivenessQ36118710
P-cadherin expression in breast cancer: a reviewQ36458759
Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancersQ43434952
The prognostic significance of P-cadherin in infiltrating ductal breast carcinomaQ43675665
Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probandsQ44316967
Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in boneQ45306974
P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinomaQ49103182
Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression.Q51778849
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.Q53588886
Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survivalQ57713449
P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytologyQ57713548
P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breastQ57713654
Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumourQ58966436
p120-ctn: A nexus for contextual signaling via Rho GTPasesQ36617587
p120-catenin: Past and presentQ36686745
P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27.Q37170854
Molecular mechanisms controlling E-cadherin expression in breast cancerQ37238311
Hereditary gastric cancerQ37469480
P-cadherin role in normal breast development and cancerQ37967582
Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancerQ38425012
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activityQ38443065
P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.Q39385880
Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.Q39745652
Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.Q39776935
P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by GSK-3beta-mediated Snail phosphorylation.Q39816900
Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasisQ39942914
P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanomaQ40365844
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.Q40382338
Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cellsQ40414876
P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cellsQ40490659
E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesisQ41931667
P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancerQ42477262
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.Q42492769
Germline E-cadherin mutations in familial lobular breast cancerQ42566631
P433issue5
P1104number of pages14
P304page(s)705-718
P577publication date2013-01-24
P1433published inJournal of PathologyQ400296
P1476titleP-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model
P478volume229

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cites work (P2860)
Q34622433Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas
Q39185024Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells.
Q45347920Authors' reply: Combining two antibodies to define E-cadherin loss of expression in non-lobular breast carcinomas: when less is more
Q38179961Beyond E-cadherin: roles of other cadherin superfamily members in cancer
Q38679713Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer.
Q89357388Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma
Q48235080Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo
Q26860953Cell adhesion and urothelial bladder cancer: the role of cadherin switching and related phenomena
Q27313331Control of cell-cell forces and collective cell dynamics by the intercellular adhesome
Q92969736E-cadherin clone 36 nuclear staining dictates adverse disease outcome in lobular breast cancer patients
Q96640858E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
Q37688972Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework
Q48215330Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells.
Q36355885Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)
Q92376723Gastric Cancer Extracellular Vesicles Tune the Migration and Invasion of Epithelial and Mesenchymal Cells in a Histotype-Dependent Manner
Q38216999Metastatic breast cancer: mechanisms and opportunities for cytology
Q27003394P-Cadherin Linking Breast Cancer Stem Cells and Invasion: A Promising Marker to Identify an "Intermediate/Metastable" EMT State
Q26781906P-cadherin and the journey to cancer metastasis
Q37718463P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells.
Q50954857P-cadherin: a useful biomarker for axillary-based breast cancer decisions in the clinical practice.
Q36567898PCDH8 is Frequently Inactivated by Promoter Hypermethylation in Liver Cancer: Diagnostic and Clinical Significance
Q92524294Prognositic significance of P-cadherin expression in breast cancer: Protocol for a meta-analysis
Q36021090Prognostic value of a 92-probe signature in breast cancer
Q58593670SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells
Q42516544Slug/Pcad pathway controls epithelial cell dynamics in mammary gland and breast carcinoma.
Q64253785The Crosstalk Between Cell Adhesion and Cancer Metabolism
Q34873875The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models
Q34309472The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype
Q54977960The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells.
Q38364407The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle
Q48299166The role of Slit-Robo signaling in the regulation of tissue barriers.

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