p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression.

scientific article published on November 2008

p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.200805113
P8608Fatcat IDrelease_ee66qocyd5gmniz637erbhxysa
P932PMC publication ID2582886
P698PubMed publication ID19015320
P5875ResearchGate publication ID23479576

P50authorLaura A MarlowQ56600296
P2093author name stringEdith A Perez
John A Copland
Masahiro Yanagisawa
Panos Z Anastasiadis
Edwin Soto
P2860cites workp120-catenin mediates inflammatory responses in the skinQ24647606
A core function for p120-catenin in cadherin turnoverQ24672238
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cellsQ24672311
A novel role for p120 catenin in E-cadherin functionQ24674430
Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherinQ24674891
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctnQ24683225
Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesionQ24683255
Cadherin superfamily genes: functions, genomic organization, and neurologic diversityQ28144697
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activationQ28188974
Altered expression of the catenin p120 in human cancer: implications for tumor progressionQ28218458
Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary glandQ28508350
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathwaysQ28511099
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexesQ28611364
Interactions between growth factor receptors and adhesion molecules: breaking the rulesQ28645747
E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent MannerQ28972449
A causal role for E-cadherin in the transition from adenoma to carcinomaQ29616122
E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactionsQ30443293
E-cadherin engagement stimulates proliferation via Rac1Q30444212
Immediate-early signaling induced by E-cadherin engagement and adhesionQ30515761
p120 catenin regulates the actin cytoskeleton via Rho family GTPasesQ33180846
The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer.Q33763276
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteinsQ33887662
Adhesion signaling: how beta-catenin interacts with its partnersQ34395476
Rho GTPases and the control of cell behaviourQ34462373
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responsesQ35734639
RAS and RHO GTPases in G1-phase cell-cycle regulationQ35762468
p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasivenessQ36118710
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesionQ36220888
The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-cateninQ36229078
E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)Q36256290
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivoQ36322263
p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctionsQ36324842
p120-ctn: A nexus for contextual signaling via Rho GTPasesQ36617587
E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.Q37616951
Inhibition of RhoA by p120 cateninQ38525924
A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic diseaseQ39599630
Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer.Q40162937
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.Q40203974
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.Q40327522
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patientsQ40338985
Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway.Q40371751
Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cellsQ40414876
Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.Q40457027
A novel interaction between kinesin and p120 modulates p120 localization and functionQ40607309
p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulationQ40609842
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.Q40738816
Cadherin engagement regulates Rho family GTPasesQ40791943
p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion.Q40828213
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.Q40857556
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor roleQ41674960
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activityQ41990554
Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.Q41998654
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factorsQ42810717
Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cellsQ42816083
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cellsQ43107815
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sitesQ43592674
E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contactsQ43823908
Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formationQ47996855
Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin.Q52194448
Genetic link between p53 and genes required for formation of the zonula adherens junction.Q52648007
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.Q52668701
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.Q53588886
Rac Activation upon Cell-Cell Contact Formation Is Dependent on Signaling from the Epidermal Growth Factor ReceptorQ63672367
E-cadherin is a survival factor for the lactating mouse mammary glandQ74244021
The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic reviewQ74553287
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
P304page(s)737-749
P577publication date2008-11-01
P1433published inJournal of Cell BiologyQ1524550
P1476titlep120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression
P478volume183

Reverse relations

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