The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant

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The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1044882172
P356DOI10.1007/S13311-014-0305-Y
P932PMC publication ID4322077
P698PubMed publication ID25256961
P5875ResearchGate publication ID266246367

P50authorBrian S TanakaQ86495711
Michael A RogawskiQ42775980
Alan GoldinQ42884134
Dorota ZolkowskaQ59260951
P2093author name stringIsaac N Pessah
Heike Wulff
Brandon M Brown
David Paul Jenkins
Hai M Nguyen
Nichole Coleman
Yi-Je Chen
Zhengyu Cao
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Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone ratQ30481496
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K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neuronsQ46201828
In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant modelsQ46520469
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Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currentsQ48919779
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant propertiesQ70146796
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In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsantQ80152918
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)234-249
P577publication date2015-01-01
P1433published inNeurotherapeuticsQ15716631
P1476titleThe riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant
P478volume12

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