Structure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificity

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Structure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificity is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M111183200
P8608Fatcat IDrelease_tj22urw2hze5dg2lu7wag34unm
P3181OpenCitations bibliographic resource ID3286765
P698PubMed publication ID11916963

P2093author name stringBoopathy Ramakrishnan
Pradman K Qasba
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Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-IQ27632731
alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-GlcQ27633866
Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding siteQ27639089
The CCP4 suite: programs for protein crystallographyQ27861090
Molecular divergence of lysozymes and alpha-lactalbuminQ28249712
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brainQ28581590
Beta-1,4-galactosyltransferase and lactose synthase: molecular mechanical devicesQ34554981
Recombinant glycodelin carrying the same type of glycan structures as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in chinese hamster ovary cellsQ40867456
Detection of epsilon(gamma-glutamyl) lysineQ41438382
Expression of deletion constructs of bovine beta-1,4-galactosyltransferase in Escherichia coli: importance of Cys134 for its activity.Q52391316
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectLactalbumin, alphaQ14901007
P304page(s)20833-9
P577publication date2002-06-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificity
P478volume277

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