Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

scientific article

Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M703800200
P932PMC publication ID2655321
P698PubMed publication ID17916560
P5875ResearchGate publication ID5927598

P50authorMatthias BuckQ41692605
Yufeng TongQ43127061
Prasanta K HotaQ58881640
Wolfram TempelQ28316856
P2093author name stringHee-Won Park
Mei Li
Limin Shen
Preeti Chugha
Rebecca S Alviani
P2860cites workPlexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebratesQ22010646
Rho GTPases have diverse effects on the organization of the actin filament systemQ24296619
Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cellsQ24301058
Semaphorins command cells to moveQ36325591
Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse.Q36328339
1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin foldQ37434673
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.Q38351580
Semaphorin-plexin signaling guides patterning of the developing vasculature.Q40538400
1H, 15N, 13C assignments for the activated form of the small Rho-GTPase Rac1.Q41884961
Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.Q42830840
A genetic algorithm for the identification of conformationally invariant regions in protein moleculesQ43864079
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.Q45003993
Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signalingQ46106917
A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targetingQ47812621
Small GTPase RhoD suppresses cell migration and cytokinesis.Q47967575
A novel NMR method for determining the interfaces of large protein-protein complexesQ73505125
Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neuronsQ81152629
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesQ24304128
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2Q24607154
The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand bindingQ24675149
Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2Q24676439
The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent mannerQ24680544
Structure of the semaphorin-3A receptor binding moduleQ27641852
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4DQ27641965
SOLVE and RESOLVE: automated structure solution and density modificationQ27860481
Coot: model-building tools for molecular graphicsQ27860505
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexesQ27860865
DaliLite workbench for protein structure comparisonQ27860897
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
Rnd proteins function as RhoA antagonists by activating p190 RhoGAPQ28184673
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin functionQ28189338
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphologyQ28215013
The semaphorin 4D receptor controls invasive growth by coupling with MetQ28219215
Rho GTPases and actin dynamics in membrane protrusions and vesicle traffickingQ28261534
The activity of the plexin-A1 receptor is regulated by RacQ28265990
PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular developmentQ28270667
The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-RasQ28275924
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect dataQ29617299
Resolution of phase ambiguity in macromolecular crystallographyQ29617474
When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteinsQ30349959
NMR techniques for identifying the interface of a larger protein-protein complex: cross-saturation and transferred cross-saturation experimentsQ30986395
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?Q33819069
The semaphorin 3A receptor may directly regulate the activity of small GTPases.Q33927427
Plexina1 autoinhibition by the plexin sema domain.Q33937108
Dual function of rhoD in vesicular movement and cell motilityQ34085798
Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.Q34108858
Plexins: axon guidance and signal transduction.Q34409838
Axon guidance: the cytoplasmic tailQ34560919
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)37215-24
P577publication date2007-12-21
P1433published inJournal of Biological ChemistryQ867727
P1476titleBinding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain
P478volume282

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cites work (P2860)
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