Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain

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Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain is …
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scholarly articleQ13442814

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P356DOI10.1016/J.STR.2007.12.012
P8608Fatcat IDrelease_ybyj4ahm5jcivko6hcifj65cm4
P932PMC publication ID2358926
P698PubMed publication ID18275816
P5875ResearchGate publication ID5575835

P50authorMatthias BuckQ41692605
Yufeng TongQ43127061
Prasanta K HotaQ58881640
P2093author name stringMehdi Bagheri Hamaneh
P2860cites workA family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptorQ24318269
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogueQ24323252
The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARGQ24535768
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2Q24607154
The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent mannerQ24680544
Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector DomainQ27648718
Structural basis for the interaction of Ras with RaIGDSQ27758740
Refinement of protein structures in explicit solventQ27860639
Automated NMR structure calculation with CYANAQ27860754
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMRQ27860778
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
DaliLite workbench for protein structure comparisonQ27860897
Protein backbone angle restraints from searching a database for chemical shift and sequence homologyQ27861108
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin functionQ28189338
Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factorsQ28198392
B plexins activate Rho through PDZ-RhoGEFQ28206278
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphologyQ28215013
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEFQ28218379
The semaphorin 4D receptor controls invasive growth by coupling with MetQ28219215
PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular developmentQ28270667
pi-Stacking interactions. Alive and well in proteinsQ28273506
The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-RasQ28275924
Molecular basis of semaphorin-mediated axon guidanceQ28611466
RECOORD: a recalculated coordinate database of 500+ proteins from the PDB using restraints from the BioMagResBankQ29614749
Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfoldingQ29620340
When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteinsQ30349959
Plexin-B1 mutations in prostate cancerQ30480866
A simultaneous (15)N, (1)H- and (13)C, (1)H-HSQC with sensitivity enhancement and a heteronuclear gradient echoQ30558652
ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic informationQ32181106
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?Q33819069
Plexins: axon guidance and signal transduction.Q34409838
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signallingQ34454518
Axon guidance: the cytoplasmic tailQ34560919
Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.Q34694762
GTPases in semaphorin signalingQ36868896
Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.Q37154008
1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin foldQ37434673
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.Q38351580
Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activityQ39729308
Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.Q40376605
Semaphorin-plexin signaling guides patterning of the developing vasculature.Q40538400
Plexin: A novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ionsQ41341072
The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopesQ42674151
Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.Q42830840
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.Q45003993
Prediction-based fingerprints of protein-protein interactions.Q45965622
Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signalingQ46106917
Specificity of the interaction between ubiquitin-associated domains and ubiquitinQ46197886
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasisQ50335578
A robust and cost-effective method for the production of Val, Leu, Ile (delta 1) methyl-protonated 15N-, 13C-, 2H-labeled proteinsQ57851005
Thermodynamic Analysis of the Structural Stability of Phage 434 Cro Protein†Q57946158
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectstructural biologyQ908902
solution structureQ99235426
P304page(s)246-58
P577publication date2008-02-01
P1433published inStructureQ15709970
P1476titleInsights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
P478volume16

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cites work (P2860)
Q27673776A Dual Binding Mode for RhoGTPases in Plexin Signalling
Q35079361A direct coupling between global and internal motions in a single domain protein? MD investigation of extreme scenarios
Q43041951Analysis of 15N-1H NMR relaxation in proteins by a combined experimental and molecular dynamics simulation approach: picosecond-nanosecond dynamics of the Rho GTPase binding domain of plexin-B1 in the dimeric state indicates allosteric pathways
Q51359776Characterizing Plexin GTPase Interactions Using Gel Filtration, Surface Plasmon Resonance Spectrometry, and Isothermal Titration Calorimetry.
Q42159319Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions
Q37154008Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.
Q27657229Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration
Q24306887Effect of cancer-associated mutations in the PlexinB1 gene
Q83232235Functional divergence of Plexin B structural motifs in distinct steps of olfactory circuit assembly
Q42719047Integrated computational approach to the analysis of NMR relaxation in proteins: application to ps-ns main chain 15N-1H and global dynamics of the Rho GTPase binding domain of plexin-B1.
Q46858331Interaction characteristics of Plexin-B1 with Rho family proteins
Q35159658Loss of plexin-B3 in hepatocellular carcinoma
Q27310828Modeling transmembrane domain dimers/trimers of plexin receptors: implications for mechanisms of signal transmission across the membrane
Q39012149Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.
Q48193128Novel modulation factor quantifies the role of water molecules in protein interactions
Q38022543Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions
Q37790755Roles of Sema4D and Plexin-B1 in tumor progression
Q24294818Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase
Q35110931Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)
Q42277883Structure and dynamics analysis on plexin-B1 Rho GTPase binding domain as a monomer and dimer
Q24309186Structure and function of the intracellular region of the plexin-b1 transmembrane receptor
Q35218537The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Q37228375Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.

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