Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif Is Required for Recognition by Toll-Like Receptor 11

scientific article

Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif Is Required for Recognition by Toll-Like Receptor 11 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JMB.2010.09.022
P8608Fatcat IDrelease_wx7mnwfi2nfjnlzbs6jqjein3i
P3181OpenCitations bibliographic resource ID4850514
P932PMC publication ID2957522
P698PubMed publication ID20851125
P5875ResearchGate publication ID46305352

P50authorYorgo ModisQ38320743
P2093author name stringKaury Kucera
Sankar Ghosh
Enrique M De La Cruz
A Alicia Koblansky
Lauren P Saunders
Kendra B Frederick
P2860cites workStructural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.Q24296423
Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparumQ24313317
Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filamentsQ24317475
Electrostatics of nanosystems: application to microtubules and the ribosomeQ24555224
Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasitesQ25257149
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASPQ27649039
Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin: INSIGHTS FROM CRYSTAL STRUCTURES OF FISSION YEAST PROFILINQ27652980
X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphatesQ27730902
The structure of crystalline profilin-beta-actinQ27732069
Structure determination and characterization of Saccharomyces cerevisiae profilinQ27764965
Interaction of actin monomers with Acanthamoeba actophorin (ADF/cofilin) and profilinQ27765325
Use of TLS parameters to model anisotropic displacements in macromolecular refinementQ27860499
Coot: model-building tools for molecular graphicsQ27860505
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensionsQ27860532
Phasercrystallographic softwareQ27860930
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculationsQ27861014
The CCP4 suite: programs for protein crystallographyQ27861090
Mutational analysis of yeast profilinQ27931447
Regulation of Profilin Localization in Saccharomyces cerevisiae by Phosphoinositide MetabolismQ27934768
A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasionQ27972938
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motilityQ28185475
Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasionQ28210733
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signalingQ28593045
The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosinQ29547591
Molecular mechanisms controlling actin filament dynamics in nonmuscle cellsQ29616514
ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacementQ29618046
A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomersQ30042138
ToxoplasmosisQ30080013
Actin filament polymerization regulates gliding motility by apicomplexan parasitesQ30477554
Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actinQ30493280
Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasitesQ33211190
How cofilin severs an actin filamentQ34051419
Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondiiQ34325778
TLR11 activation of dendritic cells by a protozoan profilin-like protein.Q34414638
Effect of cytochalasin D on Toxoplasma gondii cell entryQ34447753
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.Q34757058
Induction of an acrosomal process in Toxoplasma gondii: visualization of actin filaments in a protozoan parasiteQ35595978
Post-crystallization treatments for improving diffraction quality of protein crystals.Q36244741
Recognition and signaling by toll-like receptors.Q36527707
Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteinsQ36607555
Nucleotide-free actin: stabilization by sucrose and nucleotide binding kineticsQ38296357
Reconstitution of a functional Toll-like receptor 5 binding site in Campylobacter jejuni flagellinQ38346387
Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoitesQ40382985
Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitroQ40614205
The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.Q40647369
Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasiteQ41214560
Regulation of Phospholipase C-γ1 by Profilin and Tyrosine PhosphorylationQ43486850
Cofilin binding to muscle and non-muscle actin filaments: isoform-dependent cooperative interactionsQ45238144
Malaria parasite actin filaments are very shortQ46474283
Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin.Q47732499
Location of the creatine phosphokinase binding site of myosinQ47906416
Actin in the parasite Toxoplasma gondii is encoded by a single copy gene, ACT1 and exists primarily in a globular formQ48055571
Opposite effects of cofilin and profilin from porcine brain on rate of exchange of actin-bound adenosine 5'-triphosphateQ48520062
Protein from intestinal Eimeria protozoan stimulates IL-12 release from dendritic cells, exhibits antitumor properties in vivo and is correlated with low intestinal tumorigenicity.Q51564452
Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D.Q52568686
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactinQ59080539
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase CQ68454345
Analysis of the interactions of actin depolymerizing factor with G- and F-actinQ70480591
Purification, characterization and crystallization of human platelet profilin expressed in Escherichia coliQ72138086
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
Toxoplasma gondiiQ131003
P304page(s)616-29
P577publication date2010-11-05
P1433published inJournal of Molecular BiologyQ925779
P1476titleStructure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif Is Required for Recognition by Toll-Like Receptor 11
P478volume403

Reverse relations

cites work (P2860)
Q33778851A unique profilin-actin interface is important for malaria parasite motility
Q46242214APICOMPLEXA SPECIFIC β-HAIRPIN OF PLASMODIUM AND TOXOPLASMA PROFILINS: A MOLECULAR DYNAMICS SIMULATION STUDY.
Q34485095Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
Q37248577Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
Q37997736Holding back the microfilament--structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites
Q89516778Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum
Q93266539Inclusion of PD-L1 into a recombinant profilin antigen enhances immunity against Babesia microti in a murine model
Q37559655Innate recognition of Toxoplasma gondii in humans involves a mechanism distinct from that utilized by rodents.
Q84433718Montanide IMS 1313 N VG PR nanoparticle adjuvant enhances antigen-specific immune responses to profilin following mucosal vaccination against Eimeria acervulina
Q38182100Parasite dissemination and the pathogenesis of toxoplasmosis
Q34318100Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
Q41866313Recombinant production, crystallization and preliminary structural characterization of Schistosoma japonicum profilin
Q38045464Screening for small molecule inhibitors of Toxoplasma gondii
Q36850457TLR agonists: our best frenemy in cancer immunotherapy
Q87402503The antigen-specific response to Toxoplasma gondii profilin, a TLR11/12 ligand, depends on its intrinsic adjuvant properties
Q38375594The apicomplexan glideosome and adhesins - Structures and function
Q28731339The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain
Q35681383Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation
Q35918357Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms
Q34984865Toll-like receptor signaling in neural plasticity and disease
Q36940639Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases
Q38461991Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?
Q35871134Toxoplasma gondii profilin acts primarily to sequester G-actin while formins efficiently nucleate actin filament formation in vitro
Q27700906Two independently folding units of Plasmodium profilin suggest evolution via gene fusion
Q35827739Variation detection based on next-generation sequencing of type Chinese 1 strains of Toxoplasma gondii with different virulence from China

Search more.