X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates

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X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates is …
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scholarly articleQ13442814

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P819ADS bibcode1994PNAS...91.8636F
P356DOI10.1073/PNAS.91.18.8636
P932PMC publication ID44661
P698PubMed publication ID8078936
P5875ResearchGate publication ID15120185

P50authorKaren A. MagnusQ67936535
Steven C. AlmoQ28197196
P2093author name stringE E Lattman
A A Fedorov
T D Pollard
M H Graupe
P2860cites workIdentification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolinQ24336911
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nucleaseQ24563171
A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilinQ68254362
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase CQ68454345
Characterization of renatured profilin purified by urea elution from poly-L-proline agarose columnsQ69425510
Elucidation of the poly-L-proline binding site in Acanthamoeba profilin I by NMR spectroscopyQ72723577
Profilin as a potential mediator of membrane-cytoskeleton communicationQ75293121
The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cellsQ24657873
Structure of gelsolin segment 1-actin complex and the mechanism of filament severingQ27732041
Three-dimensional solution structure of Acanthamoeba profilin-IQ27732049
The structure of crystalline profilin-beta-actinQ27732069
How amino-acid insertions are allowed in an alpha-helix of T4 lysozymeQ27732083
Crystallographic R factor refinement by molecular dynamicsQ27860942
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbonsQ27861091
Mutational analysis of yeast profilinQ27931447
Dictyostelium discoideum contains two profilin isoforms that differ in structure and functionQ33270436
The F-actin capping proteins of Physarum polycephalum: cap42(a) is very similar, if not identical, to fragmin and is structurally and functionally very homologous to gelsolin; cap42(b) is Physarum actinQ33930134
How profilin promotes actin filament assembly in the presence of thymosin beta 4.Q34345724
Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding patternQ34346858
Purification and characterization of two isoforms of Acanthamoeba profilinQ36214079
Acanthamoeba actin and profilin can be cross-linked between glutamic acid 364 of actin and lysine 115 of profilinQ36221284
Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cellsQ36222408
Severin, gelsolin, and villin share a homologous sequence in regions presumed to contain F-actin severing domainsQ36298660
The intron-containing gene for yeast profilin (PFY) encodes a vital functionQ36849872
Actin and actin-binding proteins. A critical evaluation of mechanisms and functionsQ39740494
The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.Q40647369
Phosphoinositide-binding peptides derived from the sequences of gelsolin and villinQ41764376
Analysis of cDNA clones for Acanthamoeba profilin-I and profilin-II shows end to end homology with vertebrate profilins and a small family of profilin genesQ42618542
Regulation of Phospholipase C-γ1 by Profilin and Tyrosine PhosphorylationQ43486850
chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesisQ43854212
Cell-specific expression of a profilin gene familyQ44084975
The nucleation-release model of actin filament dynamics in cell motilityQ46316333
The primary structure of the basic isoform of Acanthamoeba profilinQ49134091
Relaxation study of the backbone dynamics of human profilin by two-dimensional 1H-15N NMR.Q52386677
Identification of the poly-L-proline-binding site on human profilin.Q54738745
Specific growth response of ras-transformed embryo fibroblasts to tumour promotersQ59078565
Structural changes in profilin accompany its binding to phosphatidylinositol 4,5‐bisphosphateQ67486972
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)8636-8640
P577publication date1994-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleX-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates
P478volume91

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cites work (P2860)
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Q36954788Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner
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Q27664562Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif Is Required for Recognition by Toll-Like Receptor 11
Q33440051Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids
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