| P50 | author | Sebastian Fica | Q86825561 |
| P2093 | author name string | Tao Wu | |
| | Matthew J Schellenberg | |
| | Andrew M MacMillan | |
| | Jonathan P Staley | |
| | Paul LaPointe | |
| | Dustin B Ritchie | |
| | Karim A Atta | |
| P2860 | cites work | Prp8 protein: at the heart of the spliceosome | Q24537373 |
| | The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site | Q24539330 |
| | Characterization of U6 snRNA-protein interactions | Q24539483 |
| | A general two-metal-ion mechanism for catalytic RNA | Q24562157 |
| | Large-scale proteomic analysis of the human spliceosome | Q24671785 |
| | Processing of X-ray diffraction data collected in oscillation mode | Q26778468 |
| | Bimolecular exon ligation by the human spliceosome bypasses early 3' splice site AG recognition and requires NTP hydrolysis | Q43206569 |
| | A novel role for a U5 snRNP protein in 3' splice site selection. | Q43728966 |
| | Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing | Q45828510 |
| | Is the spliceosome a ribonucleoprotein enzyme? | Q46668714 |
| | Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants | Q47654036 |
| | U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction | Q57080150 |
| | Metal ion catalysis during splicing of premessenger RNA | Q58324056 |
| | Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing | Q68864416 |
| | Bimolecular exon ligation by the human spliceosome | Q73407427 |
| | Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome | Q74453898 |
| | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase | Q27638224 |
| | Crystal Structure of a Self-Spliced Group II Intron | Q27650229 |
| | DNA apurinic-apyrimidinic site binding and excision by endonuclease IV | Q27650316 |
| | Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteins | Q27652048 |
| | Structural elucidation of a PRP8 core domain from the heart of the spliceosome | Q27652426 |
| | Structure and function of an RNase H domain at the heart of the spliceosome | Q27652459 |
| | Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis | Q27659258 |
| | A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases | Q27661756 |
| | Watching DNA polymerase η make a phosphodiester bond | Q27670704 |
| | Crystal structure of Prp8 reveals active site cavity of the spliceosome | Q27676016 |
| | Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs | Q27765264 |
| | Coot: model-building tools for molecular graphics | Q27860505 |
| | A graphical user interface to the CCP4 program suite | Q27860911 |
| | Refinement of macromolecular structures by the maximum-likelihood method | Q27861011 |
| | Automated main-chain model building by template matching and iterative fragment extension | Q27861082 |
| | 5-Fluoroorotic acid as a selective agent in yeast molecular genetics | Q28131614 |
| | A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome | Q28201291 |
| | Comprehensive proteomic analysis of the human spliceosome | Q28201545 |
| | Three metal ions at the active site of the Tetrahymena group I ribozyme | Q28315032 |
| | Pre-mRNA splicing: awash in a sea of proteins | Q29547272 |
| | Preparation of high molecular weight RNA | Q29614859 |
| | Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis | Q29619064 |
| | Yeast mRNA splicing in vitro | Q29620824 |
| | Spliceosome discards intermediates via the DEAH box ATPase Prp43p | Q33933327 |
| | Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1 | Q33960716 |
| | Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection | Q33967671 |
| | Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation | Q34033941 |
| | Crystal structure of a self-splicing group I intron with both exons | Q34324406 |
| | Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation | Q34610216 |
| | Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. | Q35202911 |
| | Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center | Q35203137 |
| | The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing | Q37043127 |
| | Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns | Q38315124 |
| | Roles of PRP8 protein in the assembly of splicing complexes | Q41533943 |
| | Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. | Q41899857 |
| | Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome | Q42113100 |
| | Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function | Q42397657 |
| | Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. | Q42679830 |
| P4510 | describes a project that uses | ImageQuant | Q112270642 |
| P433 | issue | 6 | |
| P921 | main subject | structural biology | Q908902 |
| P304 | page(s) | 728-734 | |
| P577 | publication date | 2013-05-19 | |
| P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
| P1476 | title | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation | |
| P478 | volume | 20 | |