| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1999PNAS...9612299S |
| P356 | DOI | 10.1073/PNAS.96.22.12299 |
| P8608 | Fatcat ID | release_cyesestwrzamhiqazw5f3gmpt4 |
| P3181 | OpenCitations bibliographic resource ID | 4299156 |
| P932 | PMC publication ID | 22911 |
| P698 | PubMed publication ID | 10535916 |
| P5875 | ResearchGate publication ID | 12764569 |
| P2093 | author name string | S. Sun | |
| A. Yoshida | |||
| D. Herschlag | |||
| J. A. Piccirilli | |||
| S.-o. Shan | |||
| P2860 | cites work | Multiple magnesium ions in the ribonuclease P reaction mechanism | Q70731237 |
| Ribozyme-mediated cleavage of a substrate analogue containing an internucleotide-bridging 5'-phosphorothioate: evidence for the single-metal model | Q71028778 | ||
| Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp | Q71395226 | ||
| A magnesium ion core at the heart of a ribozyme domain | Q73522875 | ||
| A hydrogen-bonding triad stabilizes the chemical transition state of a group I ribozyme | Q74599393 | ||
| Manganese Enzymes with Binuclear Active Sites | Q77646451 | ||
| A general two-metal-ion mechanism for catalytic RNA | Q24562157 | ||
| Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases | Q24654223 | ||
| X-ray structure and catalytic mechanism of lobster enolase | Q27729447 | ||
| Mg2+ binding to the active site of EcoRV endonuclease: a crystallographic study of complexes with substrate and product DNA at 2 A resolution | Q27730328 | ||
| Chelation of serine 39 to Mg2+ latches a gate at the active site of enolase: structure of the bis(Mg2+) complex of yeast enolase and the intermediate analog phosphonoacetohydroxamate at 2.1-A resolution | Q27730845 | ||
| Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis | Q27730870 | ||
| Catalytic metal ion binding in enolase: the crystal structure of an enolase-Mn2+-phosphonoacetohydroxamate complex at 2.4-A resolution | Q27731336 | ||
| Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase | Q27732018 | ||
| The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations | Q27733364 | ||
| Effects of substrate structure on the kinetics of circle opening reactions of the self-splicing intervening sequence from Tetrahymena thermophila: evidence for substrate and Mg2+ binding interactions | Q28776322 | ||
| Metal ion catalysis in the Tetrahymena ribozyme reaction | Q29036095 | ||
| A mechanism for all polymerases | Q29618812 | ||
| Ribozyme recognition of RNA by tertiary interactions with specific ribose 2′-OH groups | Q30442036 | ||
| Visualizing the higher order folding of a catalytic RNA molecule | Q30449417 | ||
| Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site | Q30455689 | ||
| Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site | Q30455693 | ||
| Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila | Q30457312 | ||
| Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes | Q30461610 | ||
| Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor | Q30463039 | ||
| Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme | Q30463794 | ||
| Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. | Q30464698 | ||
| The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction | Q30464699 | ||
| A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction | Q30464746 | ||
| Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site | Q30465349 | ||
| Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization | Q30468070 | ||
| Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction | Q30470692 | ||
| A second catalytic metal ion in group I ribozyme | Q30470964 | ||
| Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA | Q33953547 | ||
| Binuclear Metallohydrolases | Q34114416 | ||
| How many catalytic RNAs? Ions and the Cheshire cat conjecture. | Q34359493 | ||
| Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization | Q34366041 | ||
| Metal-binding sites in the major groove of a large ribozyme domain | Q34408837 | ||
| A minor groove RNA triple helix within the catalytic core of a group I intron | Q34482831 | ||
| A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate | Q35739284 | ||
| Ribonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site | Q37377985 | ||
| Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P. | Q38299629 | ||
| Dissection of the role of the conserved G.U pair in group I RNA self-splicing | Q38302287 | ||
| Protonated 2'-aminoguanosine as a probe of the electrostatic environment of the active site of the Tetrahymena group I ribozyme | Q38321266 | ||
| Probing the role of metal ions in RNA catalysis: kinetic and thermodynamic characterization of a metal ion interaction with the 2'-moiety of the guanosine nucleophile in the Tetrahymena group I ribozyme | Q38321270 | ||
| Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme | Q38330555 | ||
| Comparison of binding of mixed ribose-deoxyribose analogues of CUCU to a ribozyme and to GGAGAA by equilibrium dialysis: evidence for ribozyme specific interactions with 2' OH groups | Q38332437 | ||
| Quantitating tertiary binding energies of 2' OH groups on the P1 duplex of the Tetrahymena ribozyme: intrinsic binding energy in an RNA enzyme | Q38347871 | ||
| Isolation of a local tertiary folding transition in the context of a globally folded RNA. | Q38354786 | ||
| Metal ion interaction with cosubstrate in self-splicing of group I introns | Q39719033 | ||
| Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme | Q39720964 | ||
| A re-investigation of the thio effect at the hammerhead cleavage site | Q39726744 | ||
| Role of metal ions in ribozymes. | Q40993092 | ||
| Strategies for RNA folding | Q41029328 | ||
| The environment of two metal ions surrounding the splice site of a group I intron | Q41065112 | ||
| Synthesis of 3'-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry. | Q43206157 | ||
| Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition. | Q46245422 | ||
| Ribonuclease P catalysis requires Mg2+ coordinated to the pro-RP oxygen of the scissile bond. | Q54569385 | ||
| Does the Restriction EndonucleaseEcoRV Employ a Two-Metal-Ion Mechanism for DNA Cleavage?† | Q57267709 | ||
| Metal ion catalysis during splicing of premessenger RNA | Q58324056 | ||
| Dynamics of ribozyme binding of substrate revealed by fluorescence-detected stopped-flow methods | Q67596306 | ||
| Anticodon loop of tRNAPhe: structure, dynamics, and Mg2+ binding | Q68921809 | ||
| Determination of the Rate of Hexokinase-Glucose Dissociation by the Isotope-trapping Method | Q69355075 | ||
| P433 | issue | 22 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ribozyme | Q205858 |
| P304 | page(s) | 12299-12304 | |
| P577 | publication date | 1999-10-26 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Three metal ions at the active site of the Tetrahymena group I ribozyme | |
| P478 | volume | 96 |
| Q85194938 | 2′-Amino-Modified Ribonucleotides as Probes for Local Interactions Within RNA |
| Q36470727 | A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class. |
| Q27678185 | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation |
| Q34699828 | A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage |
| Q33926389 | A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme |
| Q38346273 | A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site. |
| Q27650313 | A relaxed active site after exon ligation by the group I intron |
| Q24794771 | Activity of 3'-thioAMP derivatives as ribosomal P-site substrates. |
| Q36406303 | An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions |
| Q28657572 | An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η |
| Q34787673 | An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects |
| Q34362691 | An unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction |
| Q41675293 | Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme-Cofactor Complex |
| Q30438980 | Atomic level architecture of group I introns revealed |
| Q24617627 | Biological phosphoryl-transfer reactions: understanding mechanism and catalysis |
| Q41816647 | Crystal structure of a group I intron splicing intermediate |
| Q28296661 | Crystal structure of a phage Twort group I ribozyme-product complex |
| Q34324406 | Crystal structure of a self-splicing group I intron with both exons |
| Q34024322 | Differences among mechanisms of ribozyme-catalyzed reactions |
| Q36097546 | Differential Assembly of Catalytic Interactions within the Conserved Active Sites of Two Ribozymes |
| Q34364540 | Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysis |
| Q39647190 | Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. |
| Q35946148 | Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity |
| Q89186356 | Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase η with QM/MM Free Energy Simulations |
| Q39556428 | Flanking sequences with an essential role in hydrolysis of a self-cleaving group I-like ribozyme |
| Q24812515 | Functional identification of catalytic metal ion binding sites within RNA. |
| Q41838616 | Functional identification of ligands for a catalytic metal ion in group I introns |
| Q37808954 | Functional metal ions in nucleic acids |
| Q34362552 | Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme |
| Q40518196 | How do metal ions direct ribozyme folding? |
| Q37570771 | Identification of catalytic metal ion ligands in ribozymes |
| Q95751092 | Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage |
| Q37213759 | Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway |
| Q46596344 | Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction |
| Q77456678 | Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns |
| Q30388672 | Mechanisms of Antigen Adsorption Onto an Aluminum-Hydroxide Adjuvant Evaluated by High-Throughput Screening |
| Q42871879 | Mechanisms of RNA catalysis |
| Q41834871 | Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs |
| Q34225437 | Metal ions: supporting actors in the playbook of small ribozymes |
| Q42155694 | Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding |
| Q39808443 | Microenvironment analysis and identification of magnesium binding sites in RNA |
| Q41749632 | Modulation of individual steps in group I intron catalysis by a peripheral metal ion. |
| Q27498817 | On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth |
| Q43196980 | Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes |
| Q33761964 | Probing counterion modulated repulsion and attraction between nucleic acid duplexes in solution |
| Q36559673 | Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens |
| Q36539995 | Probing the kinetic and thermodynamic consequences of the tetraloop/tetraloop receptor monovalent ion-binding site in P4-P6 RNA by smFRET. |
| Q41138427 | Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicing |
| Q34382976 | RNA catalyses nuclear pre-mRNA splicing |
| Q36991634 | RNA catalysis: ribozymes, ribosomes, and riboswitches |
| Q42726378 | Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements |
| Q28776146 | Recent advances in the elucidation of the mechanisms of action of ribozymes |
| Q36116084 | Ribozyme catalysis: not different, just worse |
| Q39991106 | Site-specific isotope labeling of long RNA for structural and mechanistic studies. |
| Q27638933 | Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron |
| Q34364582 | Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P. |
| Q40311981 | Structure and function converge to identify a hydrogen bond in a group I ribozyme active site |
| Q79106141 | Substrate 2'-hydroxyl groups required for ribozyme-catalyzed polymerization |
| Q41897439 | Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis |
| Q37924791 | Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage |
| Q34426633 | The catalytic diversity of RNAs |
| Q39535265 | The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozyme |
| Q42418767 | The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK a |
| Q24634162 | The origins of the RNA world |
| Q34749886 | The role of metal ions in RNA catalysis |
| Q38315719 | The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction |
| Q36932934 | The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction |
| Q37417135 | The structure and function of catalytic RNAs |
| Q36999638 | Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site |
| Q35841578 | Thermodynamics and kinetics for base-pair opening in the P1 duplex of the Tetrahymena group I ribozyme |
| Q42632884 | Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. |
| Q34904286 | Two decades of RNA catalysis |
| Q54361107 | Understanding catalysis of phosphate-transfer reactions by the large ribozymes. |
| Q46433023 | Use of Phosphorothioates to Identify Sites of Metal-Ion Binding in RNA |
| Q27670704 | Watching DNA polymerase η make a phosphodiester bond |
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