Structural genomics for drug design against the pathogen Coxiella burnetii

scientific article

Structural genomics for drug design against the pathogen Coxiella burnetii is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROT.24841
P3181OpenCitations bibliographic resource ID652920
P698PubMed publication ID26033498

P50authorPaul R. CarlierQ40443285
Zhong-Ke YaoQ56808302
P2093author name stringMichael Cassidy
Michael J Rudolph
Jonah Cheung
Brandan Hillerich
Maxim Totrov
James D Love
Matthew C Franklin
Fiana Burshteyn
Ebony Gary
P2860cites workComplete genome sequence of the Q-fever pathogen Coxiella burnetiiQ22066295
Protein production and purificationQ24635875
Host cell-free growth of the Q fever bacterium Coxiella burnetiiQ24656253
The subsystems approach to genome annotation and its use in the project to annotate 1000 genomesQ24817116
The infectious dose of coxiella burnetii (Q Fever)Q24824198
Basic local alignment search toolQ25938991
The ChEMBL bioactivity database: an updateQ27144224
Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugsQ27620882
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductaseQ27647158
Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analoguesQ27648883
The ssbL gene harbored by the ColV plasmid of an Escherichia coli neonatal meningitis strain is an auxiliary virulence factor boosting the production of siderophores through the shikimate pathwayQ37713174
Bacterial NADH-quinone oxidoreductasesQ37761133
Q fever: the neglected biothreat agentQ37804618
Folate: metabolism, genes, polymorphisms and the associated diseases.Q38148895
Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.Q38340921
Gene inactivation in Coxiella burnetiiQ40194030
Reduction in incidence of Q fever endocarditis: 27 years of experience of a national reference centerQ40229673
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolatesQ42551045
Analysis of the entire nucleotide sequence of the cryptic plasmid QpH1 from Coxiella burnetti.Q54026305
Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprimQ27654074
Crystal structures of Pseudomonas syringae pv. tomato DC3000 quinone oxidoreductase and its complex with NADPHQ27657741
Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductaseQ27670471
Structural Basis for the Enzymatic Formation of the Key Strawberry Flavor Compound 4-Hydroxy-2,5-dimethyl-3(2H)-furanoneQ27677382
Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate KinaseQ27678080
Discovery of Inhibitors of 4'-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial TherapyQ27679964
Crystal structure of human dihydrofolate reductase complexed with folateQ27728587
Crystal Structure ofEscherichia coliQOR Quinone Oxidoreductase Complexed with NADPHQ27729752
Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markersQ27730413
Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcaniiQ27748907
SOLVE and RESOLVE: automated structure solution and density modificationQ27860481
Protein production by auto-induction in high density shaking culturesQ27860514
CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residuesQ27860729
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomesQ27860838
Phasercrystallographic softwareQ27860930
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7Q27860936
MDR quinone oxidoreductases: the human and yeast zeta-crystallinsQ27935761
The JCSG high-throughput structural biology pipelineQ28748872
Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94Q28842789
Ligation-independent cloning of PCR products (LIC-PCR)Q29618962
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteinsQ30392381
High-throughput protein purification and quality assessment for crystallizationQ30406950
Primer Prim'er: a web based server for automated primer designQ31096421
Protein production for structural genomics using E. coli expressionQ33942234
Resistance to trimethoprim-sulfamethoxazoleQ33945728
Resistance to trimethoprim and sulfonamidesQ34296633
Dihydrofolate reductase inhibitors as antibacterial agentsQ34477235
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestisQ34483911
Novel antifolate drugsQ35065186
Characterization of a staphylococcal trimethoprim resistance gene and its productQ35540789
Docking and scoring with ICM: the benchmarking results and strategies for improvementQ36098710
A combined approach to improving large-scale production of tobacco etch virus proteaseQ36101845
VFDB 2008 release: an enhanced web-based resource for comparative pathogenomicsQ36454089
A family of LIC vectors for high-throughput cloning and purification of proteinsQ37408286
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectCoxiella burnetiiQ133971
genomicsQ222046
P304page(s)2124-2136
P577publication date2015-12-01
P1433published inProteinsQ7251514
P1476titleStructural genomics for drug design against the pathogen Coxiella burnetii
P478volume83

Reverse relations

cites work (P2860)
Q482412498-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.
Q64096704A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
Q90633335A novel method to determine antibiotic sensitivity in Bdellovibrio bacteriovorus reveals a DHFR-dependent natural trimethoprim resistance
Q43032330Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine
Q40085777Analysis of Coxiela burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulation.
Q47958933Conformational variability of the stationary phase survival protein E from Xylella fastidiosa revealed by X-ray crystallography, small-angle X-ray scattering studies, and normal mode analysis.
Q37689458Crystal Structure of the Chloroplastic Oxoene Reductase ceQORH from Arabidopsis thaliana
Q46356301Crystal structure of Rv1220c, a SAM-dependent O-methyltransferase from Mycobacterium tuberculosis
Q90312992Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities
Q40651906Crystallographic analysis of RsmA, a ribosomal RNA small subunit methyltransferase A from Staphylococcus aureus.
Q35748539Evolution of plant δ(1)-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives
Q30397156GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.
Q97645299Induced DNA bending by unique dimerization of HigA antitoxin
Q33635838Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism
Q49981005Insights into stabilizing interactions in the distorted domain-swapped dimer of Salmonella typhimurium survival protein
Q33671214Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
Q27312752Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
Q33849837Multiple Substrate Usage of Coxiella burnetii to Feed a Bipartite Metabolic Network
Q47991301Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator
Q30379925Resistance gene identification from Larimichthys crocea with machine learning techniques.
Q38930501Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.
Q93343850Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins
Q92419575Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis
Q50228642Structural and functional insights into the stationary-phase survival protein SurE, an important virulence factor of Brucella abortus
Q64106900Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H
Q64949434Structural insights into nanoRNA degradation by human Rexo2.
Q40442255Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA.
Q27704656The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism

Search more.