Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity

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Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(02)01171-6
P3181OpenCitations bibliographic resource ID2086343
P698PubMed publication ID12507428

P50authorAntonina Roll-MecakQ40436812
Jon R. LorschQ42129473
Thomas DeverQ42882444
Stephen K BurleyQ55163257
P2093author name stringByung-Sik Shin
David Maag
M Shamsul Arefin
P2860cites workPhysical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2Q24551326
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeastQ24562926
X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP bindingQ27628912
Dynamic properties of the Ras switch I region and its importance for binding to effectorsQ27631350
Comparative protein modelling by satisfaction of spatial restraintsQ27860866
The joining of ribosomal subunits in eukaryotes requires eIF5B.Q27876221
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivoQ27876228
Development and characterization of a reconstituted yeast translation initiation system.Q27934924
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiaeQ27935355
Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolutionQ27936235
A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiaeQ27936491
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeastQ27939117
The guanine nucleotide-binding switch in three dimensionsQ28131710
Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosomeQ28300603
Database of homology-derived protein structures and the structural meaning of sequence alignmentQ29614393
Initiation of translation in prokaryotes and eukaryotesQ29618237
G protein mechanisms: insights from structural analysisQ29618461
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
GTPase activity of dynamin and resulting conformation change are essential for endocytosisQ32165116
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.Q33890632
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral systemQ36551077
Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistronQ36650671
Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocationQ37382075
Late events of translation initiation in bacteria: a kinetic analysisQ40387422
Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosisQ40960042
Engaging the ribosome: universal IFs of translation.Q43819197
Visualization of elongation factor Tu on the Escherichia coli ribosome.Q54558215
Conformationally Restricted Elongation Factor G Retains GTPase Activity but Is Inactive in Translocation on the RibosomeQ59349283
Late events in translation initiation. Adjustment of fMet-tRNA in the ribosomal P-siteQ71106718
In vitro study of two dominant inhibitory GTPase mutants of Escherichia coli translation initiation factor IF2. Direct evidence that GTP hydrolysis is necessary for factor recyclingQ74485094
Binding of Escherichia coli initiation factor IF2 to 30S ribosomal subunits: a functional role for the N-terminus of the factorQ77593400
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectTranslation initiation factor eIF5B YAL035WQ27550813
P304page(s)1015-25
P577publication date2002-12-27
P1433published inCellQ655814
P1476titleUncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity
P478volume111

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cites work (P2860)
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