Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

scientific article

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1261/RNA.2412511
P932PMC publication ID3062179
P698PubMed publication ID21335519
P5875ResearchGate publication ID49849758

P50authorJon R. LorschQ42129473
Thomas DeverQ42882444
Michael G AckerQ58328435
P2093author name stringByung-Sik Shin
Joo-Ran Kim
Kathryn N Maher
Shamsul M Arefin
P2860cites workUniversal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2Q22009373
Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partnersQ24294159
Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2Q24551326
Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probingQ24676799
eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain IIQ27485879
Structure of the fMet-tRNAfMet-binding domain of B.stearothermophilus initiation factor IF2Q27622305
X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP bindingQ27628912
The joining of ribosomal subunits in eukaryotes requires eIF5B.Q27876221
Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.Q27930734
rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.Q27934058
Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinityQ27934192
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational controlQ27934439
A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiaeQ27936491
Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.Q27939079
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeastQ27939117
Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiationQ27940095
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
Translational regulation of GCN4 and the general amino acid control of yeastQ29615275
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Mapping the fMet-tRNA(f)(Met) binding site of initiation factor IF2.Q30168729
The cryo-EM structure of a translation initiation complex from Escherichia coliQ34423776
Structure of the 30S translation initiation complex.Q34596426
Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutantQ35676181
Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistronQ36650671
Kinetic analysis of late steps of eukaryotic translation initiationQ37124823
The C-terminal subdomain (IF2 C-2) contains the entire fMet-tRNA binding site of initiation factor IF2.Q38316309
Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2.Q39964572
Ribosomal localization of translation initiation factor IF2Q41820033
Solution structure of the C1-subdomain of Bacillus stearothermophilus translation initiation factor IF2.Q43058100
Engaging the ribosome: universal IFs of translation.Q43819197
Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.Q46801393
Initiator tRNA binding by e/aIF5B, the eukaryotic/archaeal homologue of bacterial initiation factor IF2.Q46814032
Interaction of fMet-tRNA(fMet) with the C-terminal domain of translational initiation factor IF2 from Bacillus stearothermophilus.Q52972760
Interaction of fMet-tRNAfMet and fMet-AMP with the C-terminal domain of Thermus thermophilus translation initiation factor 2.Q54047056
Molecular Genetic Structure–Function Analysis of Translation Initiation Factor eIF5BQ57236270
Import of proteins into mitochondria. Extramitochondrial pools and post-translational import of mitochondrial protein precursors in vivoQ72767611
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectTranslation initiation factor eIF5B YAL035WQ27550813
P304page(s)687-696
P577publication date2011-02-18
P1433published inRNAQ7277164
P1476titleStructural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability
P478volume17

Reverse relations

cites work (P2860)
Q92406628Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation
Q38286581Poliovirus switches to an eIF2-independent mode of translation during infection
Q100464114Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
Q27694629Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA
Q34384024Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages
Q34510080eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning
Q90168519eIF5B gates the transition from translation initiation to elongation
Q37641772eIF5B increases ASAP1 expression to promote HCC proliferation and invasion

Search more.