Diacylglycerol Kinase-ε: Properties and Biological Roles

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Diacylglycerol Kinase-ε: Properties and Biological Roles is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FCELL.2016.00112
P3181OpenCitations bibliographic resource ID2922137
P932PMC publication ID5067486
P698PubMed publication ID27803897

P2093author name stringRadhey S. Gupta
Bijendra Khadka
William Jennings
Mathieu Lemaire
Vincent So
Richard M. Epand
P2860cites workA conditional knockout resource for the genome-wide study of mouse gene functionQ21735918
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Properties and functions of diacylglycerol kinasesQ28143959
Enhanced T cell responses due to diacylglycerol kinase zeta deficiencyQ28190001
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory rolesQ28247080
Diacylglycerol kinase epsilon in bovine and rat photoreceptor cells. Light-dependent distribution in photoreceptor cells.Q51051911
Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes.Q51679853
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.Q52574173
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Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum.Q54336071
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sn-1,2-diacylglycerol kinase of Escherichia coli. Diacylglycerol analogues define specificity and mechanismQ68450206
Phosphorylation of Ceramide by Diglyceride Kinase Preparations from Escherichia coliQ69259484
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact plateletQ70110115
Gene expression and in situ localization of diacylglycerol kinase isozymes in normal and infarcted rat hearts: effects of captopril treatmentQ74312626
Role of the hydrophobic segment of diacylglycerol kinase epsilonQ80208828
Differential subcellular targeting and activity-dependent subcellular localization of diacylglycerol kinase isozymes in transfected cellsQ80544551
Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophyQ81751239
Catalytic activity and acyl-chain selectivity of diacylglycerol kinase ɛ are modulated by residues in and near the lipoxygenase-like motifQ83297955
The ubiquitin codeQ28265104
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signalingQ28588899
Statistical potential for assessment and prediction of protein structuresQ29615145
The basis of the substrate specificity of the epsilon isoform of human diacylglycerol kinase is not a consequence of competing hydrolysis of ATP.Q30582805
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay methodQ30981906
Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKgamma and DGKbeta are new targets of tumor-promoting phorbol estersQ31134341
Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.Q32037492
STEC-HUS, atypical HUS and TTP are all diseases of complement activationQ33403359
DGKE and atypical HUS.Q33407312
Phenotypic expansion of DGKE-associated diseasesQ33413254
Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndromeQ33417173
Characterization of a New DGKE Intronic Mutation in Genetically Unsolved Cases of Familial Atypical Hemolytic Uremic SyndromeQ33421800
Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic MicroangiopathyQ33425891
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 productionQ33430098
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death controlQ33622581
Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive functionQ33640015
Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysisQ33650414
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicityQ34236510
Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient miceQ34537391
Distinct properties of the two isoforms of CDP-diacylglycerol synthaseQ34631154
Endocannabinoids and diacylglycerol kinase activityQ34696352
p53 mutations change phosphatidylinositol acyl chain compositionQ34880855
Study of arachidonoyl specificity in two enzymes of the PI cycle.Q34984660
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.Q35108290
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signalingQ35306254
Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycleQ35610898
IBS: an illustrator for the presentation and visualization of biological sequencesQ35662095
A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.Q35894545
Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritisQ36042011
Taxonomy and function of C1 protein kinase C homology domainsQ36280307
Intracellular protein topogenesisQ36360251
Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networksQ36364136
Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growthQ36367548
C1 domains exposed: from diacylglycerol binding to protein-protein interactionsQ36544002
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GNQ36638388
Physiological roles of G protein-coupled receptor kinases and arrestinsQ36737680
Diacylglycerol kinases: why so many of them?Q36826263
Built-in loops allow versatility in domain-domain interactions: lessons from self-interacting domainsQ36869808
Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinaseQ37348000
Diacylglycerol kinase delta promotes lipogenesis.Q37395767
Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerolQ37431444
Integrated proteomic analysis of post-translational modifications by serial enrichment.Q37618636
Regulation and functions of diacylglycerol kinasesQ37908068
Regulation of diacylglycerol kinase by phosphorylationQ37946654
Enrichment of phosphatidylinositols with specific acyl chainsQ38152126
The C-terminal part of diacylglycerol kinase alpha lacking zinc fingers serves as a catalytic domainQ38353501
Diacylglycerol kinase epsilon suppresses expression of p53 and glycerol kinase in mouse embryo fibroblastsQ38407205
Molecular properties of diacylglycerol kinase-epsilon in relation to function.Q38541745
Roles of specific lipid species in the cell and their molecular mechanism.Q38732785
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodelingQ39076684
DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory SynapsesQ40125844
Molecular signatures that are distinctive characteristics of the vertebrates and chordates and supporting a grouping of vertebrates with the tunicatesQ40485873
Genetic compensation induced by deleterious mutations but not gene knockdowns.Q40744194
Loss of DGKε induces endothelial cell activation and death independently of complement activationQ41700443
Flanking residues help determine whether a hydrophobic segment adopts a monotopic or bitopic topology in the endoplasmic reticulum membraneQ41836406
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissuesQ41868492
The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester bindingQ42141639
Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanismsQ42157045
Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.Q42480957
Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modelingQ42808393
Affinity purification and catalytic properties of a soluble, Ca2+-independent, diacylglycerol kinaseQ42818366
Multiple factors influence the binding of a soluble, Ca2+-independent, diacylglycerol kinase to unilamellar phosphoglyceride vesiclesQ42818374
Arachidonoyl-diacylglycerol kinase. Specific in vitro inhibition by polyphosphoinositides suggests a mechanism for regulation of phosphatidylinositol biosynthesisQ42820246
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose productionQ42919797
ADP-Glo: A Bioluminescent and homogeneous ADP monitoring assay for kinasesQ43182928
BioID: a screen for protein-protein interactions.Q43422899
Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindlingQ44601876
Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol.Q45150942
The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerolQ45150945
Conserved inserts in the Hsp60 (GroEL) and Hsp70 (DnaK) proteins are essential for cellular growthQ45158571
Features of the Phosphatidylinositol Cycle and its Role in Signal TransductionQ46535595
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascadeQ46589753
Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampusQ46682722
Measurement of mammalian diacylglycerol kinase activity in vitro and in cellsQ46937004
Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesisQ46962028
Muroid rodents: Phylogeny and evolutionQ47293377
Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior.Q47431792
Effect of repeated seizure experiences on tyrosine hydroxylase immunoreactivities in the brain of genetically epilepsy-prone ratsQ49026160
Membrane interactions of the hydrophobic segment of diacylglycerol kinase epsilon.Q50466482
P407language of work or nameEnglishQ1860
P304page(s)112
P577publication date2016-10-18
P1433published inFrontiers in Cell and Developmental BiologyQ27725488
P1476titleDiacylglycerol Kinase-ε: Properties and Biological Roles
P478volume4

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cites work (P2860)
Q89967641CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis
Q46411250Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.
Q40051658Influenza-associated thrombotic microangiopathies.
Q58780206Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds
Q47317822LPS upregulates palmitoylated enzymes of the phosphatidylinositol cycle. An insight from proteomic studies.
Q64795552Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Q41492882Phylogenetic analysis of the diacylglycerol kinase family of proteins and identification of multiple highly-specific conserved inserts and deletions within the catalytic domain that are distinctive characteristics of different classes of DGK homolog
Q90523370Regulation of DGKε Activity and Substrate Acyl Chain Specificity by Negatively Charged Phospholipids
Q58754943Thrombotic microangiopathy after renal transplantation: Current insights in and recurrent disease

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