Technologies for controlled, local delivery of siRNA

scientific article

Technologies for controlled, local delivery of siRNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JCONREL.2015.09.066
P3181OpenCitations bibliographic resource ID4635581
P932PMC publication ID4665980
P698PubMed publication ID26476177

P50authorChristopher E NelsonQ85299050
P2093author name stringCraig L Duvall
Samantha M Sarett
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Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte filmsQ27487098
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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalizationQ30579125
Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA.Q30837863
RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.Q31120024
Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularizationQ33201362
Thermally responsive injectable hydrogel incorporating methacrylate-polylactide for hydrolytic labilityQ33615044
In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cellsQ33635879
RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria miceQ33694417
First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder.Q33730680
Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers.Q33816969
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.Q33913718
Chitosan hydrogel as siRNA vector for prolonged gene silencingQ33925196
Col V siRNA engineered tenocytes for tendon tissue engineeringQ33945381
Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid DeliveryQ33970635
Controlled release for local delivery of drugs: barriers and modelsQ34079560
Gene delivery by surface immobilization of plasmid to tissue-engineering scaffoldsQ34082344
Oncogenic KRAS signalling in pancreatic cancerQ34113460
Ocular neuroprotection by siRNA targeting caspase-2Q34192944
Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulationQ34288026
Delivery of siRNA therapeutics: barriers and carriersQ34293708
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.Q34343747
In vivo activity of nuclease-resistant siRNAsQ34365687
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesisQ34367669
Non-viral vectors for gene-based therapyQ34429032
Histidine-rich peptides and polymers for nucleic acids deliveryQ34456743
Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffoldsQ34474842
Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissuesQ34583343
Cellular and molecular basis of wound healing in diabetesQ34625159
Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyesQ34656454
Conditional deletion of gremlin causes a transient increase in bone formation and bone massQ34676851
Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle functionQ34746296
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3Q34764750
Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.Q34986363
Chitosan hydrogel for localized gene silencingQ35001428
Development of a novel endosomolytic diblock copolymer for siRNA deliveryQ35031634
BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytesQ35036611
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized miceQ35111705
Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene deliveryQ35112949
Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestinesQ35124399
Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediatorsQ35133453
Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrierQ35187370
Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic miceQ35602634
MiRNA inhibition in tissue engineering and regenerative medicineQ35799937
Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D cultureQ35855845
Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammationQ36194976
The silent treatment: siRNAs as small molecule drugsQ36362370
Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cellsQ36428234
Hyaluronic acid/chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexesQ39438965
Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation modelQ39502368
Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA.Q39506968
Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicityQ39633042
Sustained local delivery of siRNA from an injectable scaffoldQ39641314
siRNA Knockdown of Ribonucleotide Reductase Inhibits Melanoma Cell Line Proliferation Alone or Synergistically with TemozolomideQ39644504
Tolerance for mutations and chemical modifications in a siRNA.Q39698017
RNA interference by nanofiber-based siRNA delivery system.Q39742568
Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels.Q39837392
RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitroQ39878241
Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regenerationQ39976454
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).Q39983580
Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherolQ39999051
Delivery of siRNA from lyophilized polymeric surfacesQ40064683
Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle massQ40116203
Graphene multilayers as gates for multi-week sequential release of proteins from surfacesQ40127575
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infectionQ40347915
Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomoleculesQ40429544
DNA delivery from polymer matrices for tissue engineeringQ40945294
An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAsQ41281656
Tocopheryl oligochitosan-based self assembling oligomersomes for siRNA deliveryQ41617457
siRNA function in RNAi: a chemical modification analysisQ42044356
Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery.Q42077942
The Business of RNAi Therapeutics in 2012Q42212141
Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications.Q42810537
Surface-tethered DNA complexes for enhanced gene deliveryQ42815291
Snail1 down-regulation using small interfering RNA complexes delivered through collagen scaffoldsQ42832165
Cell protective, ABC triblock polymer-based thermoresponsive hydrogels with ROS-triggered degradation and drug releaseQ42835152
RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027.Q42977647
Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect modelQ43103895
Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery.Q43105872
Photo-cross-linked hydrogels from thermoresponsive PEGMEMA-PPGMA-EGDMA copolymers containing multiple methacrylate groups: mechanical property, swelling, protein release, and cytotoxicity.Q43277979
Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineeringQ43749607
Controlled release of anti-inflammatory siRNA from biodegradable polymeric microparticles intended for intra-articular delivery to the temporomandibular jointQ44000640
Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.Q44043660
Engineering mucosal RNA interference in vivoQ44055198
Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA.Q44313324
RNA interference in mammalian cells by chemically-modified RNA.Q44496696
Bioactive coronary stent coating based on layer-by-layer technology for siRNA releaseQ44582247
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escapeQ44591306
RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial VirusQ45372948
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).Q45397417
Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritisQ45668280
In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres.Q45745627
Gene silencing by adenovirus-delivered siRNA.Q45859505
Inhibition of Smad3 expression in radiation-induced fibrosis using a novel method for topical transcutaneous gene therapyQ45862302
Topical matrix-based siRNA silences local gene expression in a murine wound model.Q45869455
Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.Q45870090
Acellular dermal matrix-based gene therapy augments graft incorporationQ45872958
An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulationQ45886326
Angiogenic/osteogenic response of BMMSCs on bone-derived scaffold: effect of hypoxia and role of PI3K/Akt-mediated VEGF-VEGFR pathway.Q45962244
Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells.Q45970832
2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.Q46002868
Safety and efficacy of RNAi therapy for transthyretin amyloidosisQ46836193
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.Q46876859
How porosity and size affect the drug release mechanisms from PLGA-based microparticlesQ47348019
Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system.Q50526871
Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits.Q50983781
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.Q51562160
Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts.Q51736182
ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats.Q53068926
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.Q53960627
SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing.Q54427228
Controlled release of NFkappaB decoy oligonucleotides from biodegradable polymer microparticlesQ57188403
A novel injectable thermoresponsive and cytocompatible gel of poly( N -isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D cultureQ57349439
Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblastsQ58942414
Layer-by-Layer Assembly of All Carbon Nanotube Ultrathin Films for Electrochemical ApplicationsQ59791252
Polylysine-based transfection systems utilizing receptor-mediated deliveryQ73850333
Synthetic TGF-beta antagonist accelerates wound healing and reduces scarringQ74558114
Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNAQ80805732
Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cellsQ81227736
Localized delivery of antisense oligonucleotides by cationic hydrogel suppresses TNF-α expression and endotoxin-induced osteolysisQ82794580
Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacyQ83210784
BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systemsQ83856311
VEGF therapy: a timely retreatQ84172986
Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formationQ85025836
Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivoQ86953392
Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing.Q36471117
Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model.Q36482238
Biomimetic materials for tissue engineeringQ36502929
The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphomaQ36561226
Cell penetrating peptides: intracellular pathways and pharmaceutical perspectivesQ36795351
Matrices and scaffolds for DNA delivery in tissue engineeringQ36826532
Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism.Q36835045
Interfering with disease: a progress report on siRNA-based therapeuticsQ36836598
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimerasQ36984469
Synthesis and fabrication of a degradable poly(N-isopropyl acrylamide) scaffold for tissue engineering applicationsQ37016788
Overcoming the innate immune response to small interfering RNA.Q37071130
Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfectionQ37110938
Biodegradable polyurethanes: synthesis and applications in regenerative medicineQ37153739
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNAQ37219628
Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors.Q37262654
Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?Q37265882
Antisense makes sense in engineered regenerative medicineQ37328072
Chemical modification of siRNAs for in vivo use.Q37331765
siRNA conjugate delivery systemsQ37340480
Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivoQ37378292
Knocking down barriers: advances in siRNA deliveryQ37380671
Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts.Q37401564
Mutant KRAS is a druggable target for pancreatic cancerQ37409321
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Complexity in biomaterials for tissue engineering.Q37490816
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA deliveryQ37504038
Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) graftsQ37593277
Lipidic systems for in vivo siRNA deliveryQ37598096
Non-viral DNA delivery from porous hyaluronic acid hydrogels in miceQ37615651
Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrierQ37633656
Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Q37633993
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic applicationQ37665303
Phase I clinical trial of SYL040012, a small interfering RNA targeting β-adrenergic receptor 2, for lowering intraocular pressureQ37690494
P407language of work or nameEnglishQ1860
P304page(s)94-113
P577publication date2015-11-01
P1433published inJournal of Controlled ReleaseQ6295046
P1476titleTechnologies for controlled, local delivery of siRNA
P478volume218

Reverse relations

cites work (P2860)
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Q52671014While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action.

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