The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis

scientific article (publication date: March 1999)

The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0925-4773(98)00225-1
P3181OpenCitations bibliographic resource ID3671326
P698PubMed publication ID10330485
P5875ResearchGate publication ID12967213

P50authorAndreas HechtQ38523444
P2093author name stringR Kemler
K Vleminckx
P2860cites workSignal transduction through beta-catenin and specification of cell fate during embryogenesisQ38530598
LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.Q40875094
Armadillo and dTCF: a marriage made in the nucleusQ41600949
TCF/LEF factor earn their wingsQ41684115
Formation and function of Spemann's organizerQ41689393
Wingless signaling: the inconvenient complexities of lifeQ41720799
Beta-catenin: a key mediator of Wnt signalingQ41732761
The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cellsQ46121592
LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoterQ46178583
Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeastQ47858045
TCF: transcriptional activator or repressor?Q47926649
Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.Q48074611
LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.Q52195693
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.Q52450397
The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death.Q52454881
Drosophila Tcf and Groucho interact to repress Wingless signalling activity.Q52566295
β-Catenin Has Wnt-like Activity and Mimics the Nieuwkoop Signaling Center inXenopusDorsal–Ventral PatterningQ71816780
Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in XenopusQ73381882
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressorsQ22003989
Identification of c-MYC as a target of the APC pathwayQ24310637
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in XenopusQ24314402
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressorsQ24316983
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer functionQ28236099
From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesionQ28256172
Cell adhesion: the molecular basis of tissue architecture and morphogenesisQ28276573
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosQ28619032
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCFQ28645084
Wnt signaling: a common theme in animal developmentQ29547527
beta-catenin is a target for the ubiquitin-proteasome pathwayQ29547589
Nuclear localization of beta-catenin by interaction with transcription factor LEF-1Q29614379
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3Q29614380
Stabilization of beta-catenin by genetic defects in melanoma cell linesQ29620190
Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptorQ30420086
Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-cateninQ33775965
HMG domain proteins: architectural elements in the assembly of nucleoprotein structuresQ34060726
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryosQ34292991
Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobinQ34341469
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expressionQ34555693
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signalingQ36235397
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in XenopusQ36236595
Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axisQ36259404
Tyrosine phosphorylation and cadherin/catenin functionQ36890220
Evidence that dorsal-ventral differences in gap junctional communication in the early Xenopus embryo are generated by beta-catenin independent of cell adhesion effects.Q38334534
Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in XenopusQ38529553
WNTs modulate cell fate and behavior during vertebrate developmentQ38530050
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectAfrican clawed frogQ654718
P304page(s)65-74
P577publication date1999-03-01
P1433published inMechanisms of DevelopmentQ6804657
P1476titleThe C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis
P478volume81

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