Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions

scientific article

Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1177/1535370217708198
P932PMC publication ID5478005
P698PubMed publication ID28474989

P50authorMaocai YanQ56380847
P2093author name stringJing An
Guanqun Li
P2860cites workStructure of a human Tcf4-beta-catenin complexQ24291910
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Terminal regions of beta-catenin come into viewQ24642163
Wnt Signaling in Cancer Stem Cell BiologyQ26746101
Crystal structure of a beta-catenin/Tcf complexQ27629129
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-cateninQ27631714
Crystal Structure of a Full-Length β-CateninQ27650057
Three-dimensional structure of the armadillo repeat region of beta-cateninQ27743283
The Wnt signaling pathway in development and diseaseQ27861019
The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevisQ28144201
dishevelled and armadillo act in the wingless signalling pathway in DrosophilaQ28237239
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherinQ28252615
From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesionQ28256172
Crystal structure of a beta-catenin/BCL9/Tcf4 complexQ28269490
The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formationQ28294000
Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interactionQ83188973
WNT signalling pathways as therapeutic targets in cancerQ29615666
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complexQ31038919
2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancerQ33488429
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathwayQ33843109
An updated overview on Wnt signaling pathways: a prelude for moreQ34122601
Virtual screening methods as tools for drug lead discovery from large chemical librariesQ34422811
Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacementQ34526416
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cellsQ34787867
Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cellsQ35098096
Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like CellsQ35557572
β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.Q35585837
Can we safely target the WNT pathway?Q35591995
Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.Q35634252
Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 InteractionQ35970241
Wnt/beta-catenin signaling pathway as a novel cancer drug targetQ35971885
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin.Q36410444
Transcription under the control of nuclear Arm/beta-catenin.Q36483987
Mining the Wnt pathway for cancer therapeuticsQ36670448
CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatmentQ37190326
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
Wnt signaling in stem and cancer stem cellsQ38076537
Virtual screening in drug designQ38097356
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell controlQ38256327
Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cellsQ38314212
A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.Q38813747
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesisQ38857207
Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitorsQ39415146
Inhibition of beta-catenin/Tcf signaling by flavonoids.Q39690460
Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibitionQ39760826
High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein InteractionsQ39777606
The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cellsQ39898570
Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.Q40465905
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.Q40543122
Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesisQ40855199
Hot spots in Tcf4 for the interaction with beta-cateninQ44376501
Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions.Q51773966
Transcriptional activation of interleukin-8 by beta-catenin-Tcf4.Q52115561
Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screeningQ57937295
P433issue11
P304page(s)1185-1197
P577publication date2017-01-01
P1433published inExperimental Biology and MedicineQ15716535
P1476titleDiscovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions
P478volume242

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cites work (P2860)
Q92662040A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes
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Q90667701Insights into intestinal regeneration signaling mechanisms
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Q50322294Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
Q91844086Protein-protein interaction modulators: advances, successes and remaining challenges
Q60915232TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/β-catenin signaling
Q92236596TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes
Q90681585Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone
Q90008081The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis

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