c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

scientific article (publication date: 12 June 2003)

c-Cbl is a critical modulator of the Ron tyrosine kinase receptor is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1031393063
P356DOI10.1038/SJ.ONC.1206585
P698PubMed publication ID12802274
P5875ResearchGate publication ID10712599

P50authorGiovanni GaudinoQ29998682
P2093author name stringYosef Yarden
Chanan Rubin
Lorenza Penengo
P2860cites workInvasive growth: from development to metastasisQ34584035
Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell linesQ40841807
Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblastsQ40944647
Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanismQ40957712
Overexpression of the RON gene in human breast carcinomaQ41023826
The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.Q41758116
Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptorQ42826965
Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophagesQ43845881
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptorQ78069495
cbl-3: a new mammalian cbl family proteinQ22009959
Identification of the ron gene product as the receptor for the human macrophage stimulating proteinQ24329059
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-MetQ28207199
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsQ28609046
Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cblQ30193172
Cbl: many adaptations to regulate protein tyrosine kinasesQ34205572
Anti-apoptotic action of macrophage stimulating protein (MSP).Q34271018
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)3669-79
P577publication date2003-06-12
P1433published inOncogeneQ1568657
P1476titlec-Cbl is a critical modulator of the Ron tyrosine kinase receptor
P478volume22

Reverse relations

cites work (P2860)
Q40559949A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
Q40311788Association of RON tyrosine kinase with the Jaagsiekte sheep retrovirus envelope glycoprotein
Q39628474Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Q38112644Cbl-family proteins as regulators of cytoskeleton-dependent phenomena
Q37419861Degradation of activated protein kinases by ubiquitination
Q34405019Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase
Q44897206Development of an LC-MALDI method for the analysis of protein complexes
Q36783457Endocytosis of receptor tyrosine kinases
Q42801075Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.
Q46975253Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.
Q36877203HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation
Q35644805Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.
Q50989299Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.
Q38116308MSP-RON signalling in cancer: pathogenesis and therapeutic potential
Q38167994Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling
Q36488410Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers
Q26864275Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction
Q36545582Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma
Q26852269Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases
Q35146597RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma
Q53591553RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers.
Q40029336Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells
Q35691555Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
Q35556501Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase
Q36975164Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160
Q24313391Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Q33734632The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation
Q36280423c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses

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