The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.

scientific article published on August 2000

The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1004860569
P356DOI10.1038/SJ.ONC.1203750
P698PubMed publication ID10962563
P5875ResearchGate publication ID12358592

P2093author name stringK Vuori
E Larsen
M Garcia-Guzman
P2860cites workcbl-3: a new mammalian cbl family proteinQ22009959
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3GQ24309656
CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell MigrationQ24311510
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesQ24316242
A Grb2-associated docking protein in EGF- and insulin-receptor signallingQ24321653
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsQ24610534
Two species of human CRK cDNA encode proteins with distinct biological activitiesQ24629936
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorQ24648537
Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formationQ41711750
The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.Q41756552
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferationQ42676655
Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signalingQ42802564
Mechanism of met oncogene activationQ42811433
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.Q42824006
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor proteinQ47849795
Molecules in focus: The c-Cbl oncoproteinQ56531398
Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumoursQ77138821
Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomasQ77220529
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptorQ78069495
SH2 domains recognize specific phosphopeptide sequencesQ27860748
cbl-b inhibits epidermal growth factor receptor signalingQ28139234
Physiological signals and oncogenesis mediated through Crk family adapter proteinsQ28139609
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLQ28141139
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7Q28146026
Induction of epithelial tubules by growth factor HGF depends on the STAT pathwayQ28259695
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motilityQ28281829
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsQ28609032
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorQ29618661
The ubiquitin-proteasome pathway: on protein death and cell lifeQ29619270
The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathwayQ30175936
Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.Q30176316
Activation of the JNK pathway is essential for transformation by the Met oncogeneQ30176542
Emerging components of the Crk oncogene product: the first identified adaptor proteinQ30176868
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteinsQ30192897
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinaseQ30193184
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cellsQ30193317
Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cellsQ30194957
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinaseQ34358610
Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1Q34434226
Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356Q34434985
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.Q34449405
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.Q34482678
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alphaQ36164471
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathwayQ36565319
Activating mutations for the Met tyrosine kinase receptor in human cancerQ36595980
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migrationQ38334944
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.Q38352423
Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinaseQ39575287
Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.Q40904570
Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblastsQ40944647
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-CblQ41073646
P433issue35
P407language of work or nameEnglishQ1860
P304page(s)4058-4065
P577publication date2000-08-01
P1433published inOncogeneQ1568657
P1476titleThe proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.
P478volume19

Reverse relations

cites work (P2860)
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Q33273613Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function
Q30165423Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
Q30167857Crk family adaptors-signalling complex formation and biological roles
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Q38056547What’s in a loop?
Q28178593c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

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