Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

scientific article published on June 1999

Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1007787178
P356DOI10.1038/SJ.ONC.1202672
P698PubMed publication ID10391678
P5875ResearchGate publication ID12906907

P2093author name stringS K Shore
A Y Tsygankov
E A Feshchenko
P2860cites workC3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsQ24305258
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3GQ24309656
The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent mannerQ24310761
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulationQ24336399
A ras-related gene with transformation suppressor activityQ24338921
Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activationQ24557464
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicityQ24645473
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by RasQ28238120
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesionsQ28261445
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinasesQ28267092
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cellsQ28289338
Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cblQ28294930
B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteinsQ28298373
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphateQ28301966
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytesQ28585310
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsQ28609032
Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinaseQ28609041
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsQ28609046
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinaseQ28610005
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Integrins and signal transduction pathways: the road takenQ29547895
Catalytic specificity of protein-tyrosine kinases is critical for selective signallingQ29616451
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorQ29618661
Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferationQ30176121
Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor proteinQ30176216
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 geneQ30176545
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteinsQ30176934
Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activationQ30177028
Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor ReceptorQ30192999
Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemiaQ30193124
Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cblQ30193172
T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.Q30193176
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinaseQ30193184
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinaseQ30193228
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cellsQ30193317
Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptorsQ30193495
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alphaQ36164471
Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoterQ38289112
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migrationQ38334944
An ELISA for detection of apoptosisQ39718998
A transient three-plasmid expression system for the production of high titer retroviral vectorsQ40393091
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.Q41075804
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinaseQ41157362
Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanismQ41168715
Signaling through focal adhesion kinaseQ41359146
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.Q41966849
Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.Q42528757
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathwayQ42618265
The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.Q42802927
Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathwaysQ42807426
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.Q45989111
Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor proteinQ47849795
Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2Q57754194
Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cellsQ71742747
Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathwaysQ72315745
Mutational analysis of the role of Rap1 in regulating cytoskeletal function in DictyosteliumQ73190501
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinaseQ73224118
Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclastsQ73589789
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasionQ74037504
Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreadingQ74062887
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)3703-3715
P577publication date1999-06-01
P1433published inOncogeneQ1568657
P1476titleTyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts
P478volume18

Reverse relations

cites work (P2860)
Q35317826Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation
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Q33292321Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl
Q38038873Cbl proteins in platelet activation
Q36138338Cbl-3-deficient mice exhibit normal epithelial development
Q38112644Cbl-family proteins as regulators of cytoskeleton-dependent phenomena
Q34764852Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion
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Q28213787c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases
Q28178593c-Cbl is a critical modulator of the Ron tyrosine kinase receptor
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Q42831849c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl