Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion

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Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.11.10.3397
P932PMC publication ID15002
P698PubMed publication ID11029044
P5875ResearchGate publication ID12295420

P2093author name stringH Band
M Park
T M Fournier
L Lamorte
C R Maroun
M Lupher
W Langdon
P2860cites workFyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseQ22008672
A Grb2-associated docking protein in EGF- and insulin-receptor signallingQ24321653
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinaseQ24554529
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomasQ24624849
Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and OncogenicityQ24645473
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinaseQ27617539
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7Q28146026
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cellsQ28289338
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorQ29618661
An overview of epithelio-mesenchymal transformationQ30014826
c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphologyQ30175270
Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulationQ30176698
Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cblQ30193172
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.Q32170429
Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processingQ33263389
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceQ33776192
A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cellsQ33854830
sli-1, a negative regulator of let-23-mediated signaling in C. elegansQ33964849
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cellsQ34048204
Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1Q34434226
Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356Q34434985
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociationQ34712138
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alphaQ36164471
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathwayQ36565319
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassemblyQ36899460
Growth factors and cell movementQ37087094
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogeneQ37636620
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migrationQ38334944
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.Q38352423
Isoforms of the met receptor tyrosine kinaseQ40851043
Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblastsQ40944647
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-CblQ41073646
Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.Q41270218
Epithelial-mesenchymal transitions in cancer progressionQ41449306
Model systems of epithelium-mesenchyme transitionsQ41449313
Receptor chimeras indicate that the met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor.Q41477545
The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptorQ41532585
The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cellsQ41563732
The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.Q41756552
Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase associationQ42467874
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferationQ42676655
Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signalingQ42802564
Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.Q42830640
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.Q45989111
Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor proteinQ47849795
Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesisQ72809299
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinaseQ73224118
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptorQ78069495
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)3397-3410
P577publication date2000-10-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleCbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion
P478volume11

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cites work (P2860)
Q40559949A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
Q34405560Beyond the RING: CBL proteins as multivalent adapters
Q37370673Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis
Q38112644Cbl‐family proteins as regulators of cytoskeleton‐dependent phenomena
Q27860487Epithelial-mesenchymal transitions in tumour progression
Q34286540HGF and ligation of alphavbeta5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering
Q33314672Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
Q24681561LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy
Q37232416MET as a target for treatment of chest tumors
Q38430194MET: a new promising biomarker in non-small-cell lung carcinoma
Q58776408Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers
Q35620884Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.
Q28210330Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
Q34452683Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.
Q28278555Prostate cancer and the met hepatocyte growth factor receptor
Q40601255Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells
Q33383797TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer.
Q46476342The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules
Q33736621Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells
Q33850376Valproic acid, targets papillary thyroid cancer through inhibition of c-Met signalling pathway

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