Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

scientific article (publication date: May 1992)

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/0092-8674(92)90444-H
P3181OpenCitations bibliographic resource ID1341052
P698PubMed publication ID1374684

P50authorWendy J. FantlQ111444697
Lewis T. WilliamsQ111445253
Jaime A. EscobedoQ111458215
P2093author name stringF. McCormick
C. W. Turck
G. A. Martin
M. del Rosario
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)413-23
P577publication date1992-05-01
P1433published inCellQ655814
P1476titleDistinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
P478volume69

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cites work (P2860)
Q30194697A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins
Q34661632A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration.
Q33781691A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction
Q24321185A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
Q24600945A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction
Q24337740A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding
Q30194817A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo
Q74505910A screening method of SH2 domain ligands and blockers using a solid phase binding
Q24291278A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
Q26827433A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation
Q28286805A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex
Q24308705Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor
Q41441452Activation of p70/p85 S6 kinase by a pathway independent of p21ras
Q37223924Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells
Q41471394Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
Q24310840Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
Q46226598Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors
Q24310421Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes
Q46628781Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis
Q39610838An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement
Q34052239An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.
Q36701137Association and phosphorylation-dependent dissociation of proteins in the insulin receptor complex
Q36550151Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin
Q42016191Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component
Q22009127Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
Q24614033Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
Q46452809Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells
Q24652890Binding of NCK to SOS and activation of ras-dependent gene expression
Q30194700Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides
Q37083934Binding specificity of SH2 domains: insight from free energy simulations
Q36234748Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.
Q33575831Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor
Q72080393CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase
Q40017821CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation
Q24610534CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
Q24336526CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
Q41332143CTLA-4, a negative regulator of T-lymphocyte activation
Q39451271Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide
Q41566544Cell-free activation of a DNA-binding protein by epidermal growth factor
Q39455488Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Q40812896Cellular insulin action and insulin resistance
Q24629213Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
Q27323236Coarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylation
Q41653302Common and distinct elements in insulin and PDGF signaling
Q42828420Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells
Q53426359Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis
Q36794168Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase
Q37170738Construction of a disulfide-stabilized diabody against fibroblast growth factor-2 and the inhibition activity in targeting breast cancer.
Q24315793Construction of an SH2 domain-binding site with mixed specificity
Q40626553Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor
Q42797857Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes
Q27642117Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
Q27729401Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
Q24310206Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
Q39610954Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
Q36836176Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
Q40374535Definition of signals for neuronal differentiation
Q28287661Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors
Q41814651Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase
Q42815996Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates
Q42844403Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S.
Q28302000Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
Q24613360Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta
Q24310893Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions
Q40946341Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
Q31712047Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase
Q36643816Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members
Q30195067En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase
Q36234800Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
Q28571849Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes
Q40958225Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate
Q41569759Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors
Q41489707Farnesyltransferase as a target for anticancer drug design
Q36232058Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells
Q40727590Fc receptor-mediated signal transduction
Q60063644Fishing in Src-infested waters
Q28504776Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
Q40733286Focal adhesion as a signal transduction organelle
Q36656886Functional specificity of cytoplasmic and transmembrane tyrosine kinases: identification of 130- and 75-kilodalton substrates of c-fps/fes tyrosine kinase in macrophages
Q22008672Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
Q74643559Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathway
Q24610035Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity
Q33934157Genetic screening and functional characterization of PDGFRB mutations associated with basal ganglia calcification of unknown etiology
Q34453826Gi2-mediated activation of the MAP kinase cascade
Q28593533Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain
Q28269071Guanosine Triphosphatase-Activating Protein-Associated Protein, But Not src-Associated Protein p68 in Mitosis, Is a Part of Insulin Signaling Complexes*
Q40882225Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells
Q24305821Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
Q34386778Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure
Q46116292IP3 receptor blockade fails to prevent intracellular Ca2+release by ET-1 and α-thrombin
Q30194902Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts
Q34981771Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain
Q41199335Identification of a domain within the carboxyl-terminal region of the beta platelet-derived growth factor (PDGF) receptor that mediates the high transforming activity of PDGF.
Q38291369Identification of a putative Syp substrate, the PDGF beta receptor
Q24595150Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera
Q37556986Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome
Q24308600Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
Q24293518Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma
Q24309883Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
Q24291107Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
Q24314627In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
Q40956511Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding
Q41617077Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins
Q40973684Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway
Q41131139Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase
Q72659475Inhibition of PDGF BB stimulated DNA synthesis in rat aortic vascular smooth muscle cells by the expression of a truncated PDGF beta receptor
Q40887496Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties
Q33832620Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor
Q40858638Insulin and IGF-I signaling through the insulin receptor substrate 1.
Q41038789Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC).
Q39750687Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
Q36824805Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase
Q28592322Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation
Q30439814Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Q24337412Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes
Q36686508Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach
Q37359399Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.
Q42674535Interleukin‐7 induces the association of phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor
Q35764632Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor
Q44124902Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes
Q41544830Involvement of a phosphotyrosine protein phosphatase in the suppression of platelet-derived growth factor receptor autophosphorylation in ras-transformed cells
Q24315142Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22
Q47756210Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis
Q34811265Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.
Q36325295Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance
Q36273792Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit
Q36550896Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling
Q42805513Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor
Q24306895Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal
Q40696307Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells
Q36669823Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression
Q36821017Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells
Q41101260Molecular basis of skeletal muscle regeneration
Q24292745Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62
Q35014319Molecular recognition by SH2 domains
Q36487331Molecular separation of two signaling pathways for the receptor, Notch
Q36236949Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
Q28587864Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts
Q41077471Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
Q35846414Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.
Q40790586Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function
Q40791389Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
Q40794603New insights into protein-tyrosine kinase receptor signaling complexes
Q46205923Non-capacitative Calcium Entry in Chinese Hamster Ovary Cells Expressing the Platelet-derived Growth Factor Receptor
Q38084894Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis
Q38314625Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours
Q30194476Oncogenes, protein tyrosine kinases, and signal transduction
Q41355420PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
Q28244045PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
Q38615308PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway
Q40790718PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.
Q40790710PI 3-kinase: structural and functional analysis of intersubunit interactions
Q50297839PI3-kinase binds to the active receptor
Q54527804PI3K signalling: the path to discovery and understanding
Q22011152PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis
Q40715319Pathways of Ras function: connections to the actin cytoskeleton.
Q30986609Peptide library screening for determination of SH2 or phosphotyrosine-binding domain sequences
Q31992313Peptide modulators of protein–protein interactions in intracellular signaling
Q24629183Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase
Q30452661Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation
Q30194718Phosphatidylinositol 3-kinase activity is important for progesterone-induced Xenopus oocyte maturation
Q41336419Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
Q30167836Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.
Q42807426Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
Q40874030Phosphatidylinositol 3′-kinase associates with p145c-kit as part of a cell type characteristic multimeric signalling complex
Q41489425Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction
Q41174456Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase
Q29620177Phosphatidylinositol-3-OH kinase as a direct target of Ras
Q42844293Phosphopeptide binding to the N‐terminal SH2 domain of the p85α subunit of PI 3′‐kinase: A heteronuclear NMR study
Q40402454Phosphorylation of the nicotinic acetylcholine receptor by protein tyrosine kinases
Q44729061Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Q28289418Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
Q36564274Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation
Q28645716Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1
Q34627225Phosphotyrosine-binding domains in signal transduction
Q24336479Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
Q41662746Physiological Function of Receptor-SH2 Interactions
Q42802895Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation
Q41289581Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle
Q41507086Platelet-derived growth factor induces phosphatidylinositol 3-kinase release from the middle T-pp60c-src complex and association with the platelet-derived growth factor receptor
Q36690316Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein
Q28645713Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types
Q42807654Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation
Q40609877Platelet-derived growth factor receptor-mediated signal transduction from endosomes
Q38258904Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies
Q34684084Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor
Q36563209Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
Q41480620Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
Q40821933Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth
Q46552554Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis
Q35569826Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.
Q52530471Polyomavirus Middle T Antigen as a Probe for T Cell Antigen Receptor-coupled Signaling Pathways
Q41540271Pool of ligand‐bound platelet‐derived growth factor β‐receptors remain activated and tyrosine phosphorylated after internalization
Q37385906Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor
Q41038475Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C epsilon
Q33888373Proliferative and apoptotic responses in cancers with special reference to oral cancer
Q33719385Prospects for drug screening using the reverse two-hybrid system
Q39446908Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.
Q29618388Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Q39630940Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Q41191785Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation
Q27860694Protein modules and signalling networks
Q44878387Purification and Characterization of a Soluble Phosphatidylinositol 4-Kinase from Carrot Suspension Culture Cells
Q42438790Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol
Q41442377Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85
Q24321244Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
Q73510887Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation
Q39585343Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth
Q34465364RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology
Q27729903Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck
Q38350671Reexamining interaction of the SH2 domains of SYP and GAP with insulin and IGF-1 receptors in the two-hybrid system
Q24322699Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2
Q41488423Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
Q33904740Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus
Q46078497Relaxin activates the MAP kinase pathway in human endometrial stromal cells
Q28143168Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses
Q42803242Requirement of phosphatidylinositol 3-kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
Q41706399Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA.
Q35170183Retrograde factors in peripheral nerves
Q24309394Role of CD4 and CD8 in T cell activation and differentiation
Q30194282Role of IRS-1-GRB-2 complexes in insulin signaling
Q41992885Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating
Q29615222Role of platelet-derived growth factors in physiology and medicine
Q36676458SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence
Q34057752SH2 domain specificity and activity modified by a single residue
Q28199016Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling
Q37334950Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution
Q24313100Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
Q42827298Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors
Q38314926Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation
Q28513453Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors
Q34720232Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells
Q40406776Signal transduction by Ras-like GTPases: a potential target for anticancer drugs
Q40500421Signal transduction by the antigen receptors of B and T lymphocytes.
Q28609164Signal transduction via platelet-derived growth factor receptors
Q41559204Signaling Mechanisms in Growth Factor‐Stimulated Cell Motility
Q41553992Simultaneous induction of stimulatory and inhibitory signals by PDGF
Q22254150Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
Q28645766Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control
Q28291452Specific binding of Fyn and phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
Q29615971Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav
Q24314456Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
Q36235805Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction
Q22010243Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors
Q30194870Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells
Q24680080Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
Q42160617Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.
Q34305587Strongyloides stercoralis age-1: a potential regulator of infective larval development in a parasitic nematode.
Q42826060Structural Requirements of the Epidermal Growth Factor Receptor for Tyrosine Phosphorylation of eps8 and eps15, Substrates Lacking Src SH2 Homology Domains
Q24555662Structural and functional studies on platelet-derived growth factor
Q27759524Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands
Q41572802Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins. Evidence from reactivity to monoclonal antibodies
Q24324349Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase
Q27642078Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
Q24317353Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor
Q40490475Structure-function analyses of the kit receptor for the steel factor
Q36872364Synthesis and characterization of histidine‐phosphorylated peptides
Q35096703T cell anergy and costimulation
Q28300793T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras
Q24310233T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
Q74016240Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling
Q34393461Targeting the PDGF signaling pathway in tumor treatment
Q24310396The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
Q40488860The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes
Q41050852The Epidermal Growth Factor Receptor Associates with and Recruits Phosphatidylinositol 3-Kinase to the Platelet-derived Growth Factor β Receptor
Q29618141The GTPase dynamin binds to and is activated by a subset of SH3 domains
Q36551325The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1
Q28287741The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit
Q40733281The Ras signal transduction pathway
Q24336226The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
Q24600605The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment
Q36485178The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells
Q33933167The biochemical and physiological characteristics of receptors
Q28367583The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes
Q36235836The chemotactic response to PDGF-BB: evidence of a role for Ras.
Q41469848The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase
Q58165507The hepatocyte growth factor receptor (MET): An unconventional transducer of mitogenic and motogenic signals
Q36745695The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Q35769059The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors
Q37454384The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.
Q73909431The phosphopeptide-binding specificity of Src family SH2 domains
Q36678826The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif
Q37764745The regulation of class IA PI 3-kinases by inter-subunit interactions
Q40454708The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors.
Q41568721The role of the IGF-1 receptor in the stimulation of cells by short pulses of growth factors
Q40942505The synthesis and compositional analysis of phosphopeptides
Q47806493Transmembrane signaling in periodontal mesenchymal cells: the linkage between stimulus and response
Q41341486TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells
Q41323243Two SH2 Domains of p120 Ras GTPase-activating Protein Bind Synergistically to Tyrosine Phosphorylated p190 Rho GTPase-activating Protein
Q40549695Two conserved cysteine residues are critical for the enzymic function of the human platelet-derived growth factor receptor-beta: evidence for different roles of Cys-822 and Cys-940 in the kinase activity
Q24311075Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor
Q24609334Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation
Q40872205Tyrosine 785 is a major determinant of Trk--substrate interaction
Q30452619Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP
Q54091334Tyrosine Phosphorylation of Insulin Receptor Substrate-1 and Activation of the PI-3-Kinase Pathway by Glycine-Extended Gastrin Precursors
Q35156272Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor
Q42808291Tyrosine phosphorylation of the juxtamembrane domain of the v-Fms oncogene product is required for its association with a 55-kDa protein
Q41157391Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells.
Q36658598Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively
Q41010604Upstream-downstream: CD28 cosignaling pathways and T cell function
Q55065488Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.
Q27938850Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
Q40790197William L. McGuire Memorial Symposium. Control of breast cancer cell growth by steroids and growth factors: interactions and mechanisms
Q41966849Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.
Q36561273YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites
Q30308392c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes
Q30193694src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity

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