Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMGME.2003.08.016
P3181OpenCitations bibliographic resource ID1022177
P698PubMed publication ID14567964
P5875ResearchGate publication ID231583355

P50authorJames WilsonQ16947166
P2093author name stringAdam Bagg
Frank S Lee
Guang-ping Gao
Mark L Batshaw
Narendra Chirmule
Nelson A Wivel
Steven E Raper
P2860cites workTreatment of episodic hyperammonemia in children with inborn errors of urea synthesisQ28268241
The acute respiratory distress syndromeQ29615140
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.Q33337331
A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiencyQ33340517
Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytesQ33903377
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapyQ35232341
Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenovirusesQ35837026
The pathogenesis of sepsisQ37251283
Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytesQ37351823
Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenovirusesQ39879953
Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trialQ40586745
Infections and the inflammatory response in acute respiratory distress syndromeQ40651722
Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectorsQ40942254
Update on the mechanisms of immune suppression of injury and immune modulationQ41004765
Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?Q41210322
Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: evidence for prolonged stability and activity of the transgene in liverQ41245959
The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemiaQ41354708
MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.Q41664847
Liver transplantation for the treatment of urea cycle disordersQ41926237
Selective gene transfer into the liver of non-human primates with E1-deleted, E2A-defective, or E1-E4 deleted recombinant adenoviruses.Q42676162
Activation of coagulation after administration of tumor necrosis factor to normal subjectsQ43690695
Persistent transgene expression in mouse liver following in vivo gene transfer with a delta E1/delta E4 adenovirus vectorQ43693238
Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: safety of readministrationQ45863202
Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liverQ45874045
Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectorsQ45876696
Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophagesQ45877053
Adenovirus-mediated in vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challengeQ45881297
Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liverQ45889223
Evaluating the potential of germ line transmission after intravenous administration of recombinant adenovirus in the C3H mouse.Q45889451
Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products.Q53916620
Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors.Q54563329
Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) MiceQ61456119
Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vectorQ64378881
Mosaicism for an intragenic deletion in a boy with mild ornithine transcarbamylase deficiencyQ69837464
Postinjury multiple organ failure: a bimodal phenomenonQ71039840
Pattern of soluble TNF receptors I and II in sepsisQ71585158
Early predictors of postinjury multiple organ failureQ72703617
Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failureQ73440283
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
inflammationQ101991
patientQ181600
systemic inflammatory response syndromeQ776030
P304page(s)148-58
P577publication date2003-01-01
P1433published inMolecular Genetics and MetabolismQ6895949
P1476titleFatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
P478volume80

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cites work (P2860)
Q54461045A Comparative Safety Profile Assessment of Oncolytic Virus Therapy Based on Clinical Trials.
Q27484994A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques
Q92020423A Molecular Revolution in the Treatment of Hemophilia
Q36098953A concise peer into the background, initial thoughts and practices of human gene therapy
Q33258821A look to future directions in gene therapy research for monogenic diseases
Q37150738A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism
Q57367323A nanogel with passive targeting function and adjustable polyplex surface properties for efficient anti-tumor gene therapy
Q24599954A new generation of human artificial chromosomes for functional genomics and gene therapy
Q37590085A new link between virus cell entry and inflammation: adenovirus interaction with integrins induces specific proinflammatory responses
Q40478238A nonviral vector with transfection activity comparable with adenoviral transduction.
Q33945612A novel MVA vectored Chikungunya virus vaccine elicits protective immunity in mice
Q35641856A novel and simple method for rapid generation of recombinant porcine adenoviral vectors for transgene expression
Q33586974A pRb-responsive, RGD-modified, and hyaluronidase-armed canine oncolytic adenovirus for application in veterinary oncology
Q40479387A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer.
Q45872533A polymerase chain reaction-based methodology to detect gene doping
Q59352404A practical guide to the handling and administration of personalized transcriptionally attenuated oncolytic adenoviruses (PTAVs)
Q36920480A rapid Q-PCR titration protocol for adenovirus and helper-dependent adenovirus vectors that produces biologically relevant results.
Q45879506A realistic chance for gene therapy in the near future
Q38954393A reduction in the human adenovirus virion size through use of a shortened fibre protein does not enhance muscle transduction following systemic or localised delivery in mice.
Q40403870A remarkable permeability of canalicular tight junctions might facilitate retrograde, non-viral gene delivery to the liver via the bile duct
Q40011736A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors
Q38651271A snapshot of biologic drug development: Challenges and opportunities
Q45875379A syringe-focused ultrasound device for simultaneous injection of DNA and gene transfer
Q36410697A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection
Q35027496AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects
Q34716958AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models
Q35686509ARE/SUZ12 dual specifically-regulated adenoviral TK/GCV system for CML blast crisis cells
Q42412771Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma
Q21134608Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection
Q35791792Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach
Q38981492Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models
Q38188560Adeno-associated virus structural biology as a tool in vector development
Q34317131Adeno-associated virus-mediated gene transfer
Q39303013Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.
Q40357603Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury.
Q37967604Adenoviral load diagnostics by quantitative polymerase chain reaction: techniques and application
Q40424880Adenoviral p53 gene transfer and gemcitabine in three patients with liver metastases due to advanced pancreatic carcinoma
Q30370445Adenoviral vectors as novel vaccines for influenza.
Q39654400Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells
Q34977219Adenovirus
Q33389860Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
Q28084476Adenovirus membrane penetration: Tickling the tail of a sleeping dragon
Q39065475Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy
Q64376894Adenovirus toxicity and tropism in vivo: not as simple as A,B,C (or D,E,F)
Q39706964Adenovirus vector delivery stimulates natural killer cell recognition.
Q27001601Adenovirus vectors for gene therapy, vaccination and cancer gene therapy
Q89606305Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial
Q41699782Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine
Q38187126Adenovirus-triggered innate signalling pathways
Q37951524Adenovirus-vectored drug-vaccine duo as a potential driver for conferring mass protection against infectious diseases
Q38295771Adenoviruses as gene/vaccine delivery vectors: promises and pitfalls
Q36132288Adenoviruses for treatment of cancer
Q37335982Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK.
Q27011815Adipocytes as a vehicle for ex vivo gene therapy: Novel replacement therapy for diabetes and other metabolic diseases
Q54342284Advances in the management of disseminated adenovirus disease in stem cell transplant recipients: impact of adenovirus load (DNAemia) testing.
Q37118764An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression
Q37144360An overview of biochemical genetics
Q96302902An overview of development in gene therapeutics in China
Q37863587An update on gene therapy in Parkinson's disease
Q40815226Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors
Q33558337Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models
Q45874236Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits
Q35628601Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice
Q91866605Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy
Q37355005Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction
Q36790320Arthritis gene therapy's first death
Q40439258Augmentation of transgene expression in cold-preserved organs using vascular endothelial growth factor receptor-mediated adenoviral vector combined with hyperbaric oxygen
Q50519704Baculovirus as delivery system for gene transfer during hypothermic organ preservation.
Q36298627Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques
Q51857382Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors.
Q39342777Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
Q33803963Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging
Q40091715Biodistribution and safety profile of recombinant adeno-associated virus serotype 6 vectors following intravenous delivery.
Q37176436Biological approaches to ischemic tissue repair: gene- and cell-based strategies
Q90259836Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair
Q92339833Biosafety, and improvement of osteoporosis in cage layers through using chOPG protein
Q36695688CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness
Q33687979CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies
Q98771286CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future
Q98292026CRISPR-Cas9-Mediated In Vivo Gene Integration at the Albumin Locus Recovers Hemostasis in Neonatal and Adult Hemophilia B Mice
Q33632925CRISPR/Cas9: Transcending the Reality of Genome Editing
Q39294371CRISPR/Cas9: at the cutting edge of hepatology.
Q33711997Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.
Q46467541Can ultrasound solve the transport barrier of the neural retina?
Q40329093Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors.
Q42424335Capsid-modified adenoviral vectors for improved muscle-directed gene therapy
Q27014770Cardiovascular gene therapy for myocardial infarction
Q36040801Cationic lipid-DNA complexes for non-viral gene therapy: relating supramolecular structures to cellular pathways
Q33257608Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications
Q36251313Cell transplantation for diabetes
Q36272601Cell-specific targeting of lipid-based carriers for ODN and DNA.
Q36473038Cellular and genetic therapies for haemophilia
Q33265007Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect
Q34607182Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo
Q50977875Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy.
Q37849777Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease
Q64378490Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses
Q26995655Circumventing antivector immunity: potential use of nonhuman adenoviral vectors
Q35558172Clinical review: gene-based therapies for ALI/ARDS: where are we now?
Q64375676Cloning of carrier cells infected with oncolytic adenovirus driven by midkine promoter and biosafety studies
Q36495546Clostridial spores as live 'Trojan horse' vectors for cancer gene therapy: comparison with viral delivery systems.
Q27332110Coagulation factor X activates innate immunity to human species C adenovirus
Q64378634Coagulation factor defends adenovirus from immune attack
Q37980864Cocaine hydrolase gene therapy for cocaine abuse
Q34389675Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.
Q33659517Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors
Q36600228Combining cell therapy and nanotechnology
Q37309252Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model.
Q45865539Congenital muscular dystrophy: mini-agrin delivers in mice
Q34977697Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels
Q36969510Contrasting features of urea cycle disorders in human patients and knockout mouse models
Q37676230Correction of Monogenic and Common Retinal Disorders with Gene Therapy
Q34774816Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors
Q64930555Current Landscape of Heart Failure Gene Therapy.
Q37841547Current options and new developments in the treatment of haemophilia
Q35881934Current status and prospects for gene therapy
Q36823697Current status of cardiovascular gene therapy
Q38862302Current status of ex vivo gene therapy for hematological disorders: a review of clinical trials in Japan around the world
Q35667739Current status of immunotherapy for the treatment of lung cancer.
Q38184158DNA cleavage enzymes for treatment of persistent viral infections: recent advances and the pathway forward.
Q36250777DNA-based therapeutics and DNA delivery systems: a comprehensive review
Q38321960De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications
Q40256121Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses
Q38912667Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives
Q37677605Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences
Q38356303Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE.
Q27007011Design and application of multifunctional DNA nanocarriers for therapeutic delivery
Q37299072Designing heart performance by gene transfer.
Q38003108Detection of EPO gene doping in blood
Q33637630Development of a gene transfer-based treatment for radiation-induced salivary hypofunction
Q36065953Development of mammalian artificial chromosomes for the treatment of genetic diseases: Sandhoff and Krabbe diseases
Q26823376Developments in the treatment of hemophilia B: focus on emerging gene therapy
Q38145327Diagnosis and treatment of adenovirus infection in immunocompromised patients
Q33835146Direct gene therapy for bone regeneration: gene delivery, animal models, and outcome measures.
Q34652434Dual gene expression in embryoid bodies derived from human induced pluripotent stem cells using episomal vectors
Q37664701Durable expression of minicircle DNA-liposome-delivered androgen receptor cDNA in mice with hepatocellular carcinoma
Q35684857Ebola virus glycoproteins: guidance devices for targeting gene therapy vectors
Q40528538Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats
Q30436033Effect of nonviral plasmid delivered basic fibroblast growth factor and low intensity pulsed ultrasound on mandibular condylar growth: a preliminary study.
Q39842450Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer
Q39491840Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer
Q37925857Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies
Q45008585Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia.
Q52431143Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9
Q41782046Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles
Q34999733Efficient gene transfer and durable transgene expression in grafted rabbit veins
Q33267297Efficient non-viral ocular gene transfer with compacted DNA nanoparticles
Q33713289Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates
Q45061679Electroporation-mediated transfer of plasmid DNA encoding IL-10 attenuates orthotopic tracheal allograft stenosis in rats.
Q50187342Elixir of Life: Thwarting Aging With Regenerative Reprogramming
Q89603279Emerging patent landscape for non-viral vectors used for gene therapy
Q36960845Emerging strategies for cell and gene therapy of the muscular dystrophies
Q37822290Emerging therapeutic approaches in the management of retinal angiogenesis and edema.
Q36967723Emerging therapies for mitochondrial disorders
Q36764543Encapsulation of nucleic acids and opportunities for cancer treatment
Q37567831Engineered adenovirus serotypes for overcoming anti-vector immunity
Q39077630Engineered retroviral virus-like particles for receptor targeting
Q38150365Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy.
Q37380704Enhanced bone morphogenic protein adenoviral gene delivery to bone marrow stromal cells using magnetic nanoparticle
Q38938407EpCAM-targeted liposomal si-RNA delivery for treatment of epithelial cancer.
Q40379092Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination
Q38738678Equine performance genes and the future of doping in horseracing.
Q45885660Eradication of hepatocellular carcinoma xenografts by radiolabelled, lipiodol-inducible gene therapy
Q38874665Ethical considerations and challenges in first-in-human research
Q33799990Evaluation of signal transduction pathways after transient cutaneous adenoviral gene delivery.
Q26775030Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
Q31114544Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus
Q89540000Expression of Neprilysin in Skeletal Muscle by Ultrasound-Mediated Gene Transfer (Sonoporation) Reduces Amyloid Burden for AD
Q38647828Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis
Q39946262Extended release of adenovirus from silica implants in vitro and in vivo
Q36715322Extracorporeal delivery of rAAV with metabolic exchange and oxygenation
Q45875328Factors influencing retention of adenovirus within tumours following direct intratumoural injection.
Q36305902Fatal coma in a young adult due to late-onset urea cycle deficiency presenting with a prolonged seizure: a case report
Q35434767Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events
Q38119906From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?
Q37696495Future of cell and gene therapies for Parkinson's disease
Q38199215GLP-1-mediated gene therapy approaches for diabetes treatment
Q30439944GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk
Q33891559Gene Therapy 2017: Progress and Future Directions
Q91610685Gene Therapy Today and Tomorrow
Q28595868Gene Therapy for Metabolic Diseases
Q37470623Gene and cell therapy for heart failure
Q38000390Gene delivery to bone
Q37171838Gene doping: the hype and the reality.
Q33691825Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons
Q36532106Gene therapeutics: the future of brain tumor therapy?
Q37669606Gene therapies development: slow progress and promising prospect
Q35904004Gene therapy applications of viral vectors
Q28083399Gene therapy approaches to regenerating the musculoskeletal system
Q41465719Gene therapy as a treatment concept for inherited retinal diseases
Q80448411Gene therapy for arthritis
Q35117004Gene therapy for bone healing
Q35040146Gene therapy for cancer treatment: past, present and future
Q36800517Gene therapy for cardiac arrhythmias: a dream soon to come true?
Q26799437Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
Q38059008Gene therapy for cardiovascular disease: perspectives and potential
Q38132253Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium
Q83556143Gene therapy for heart failure
Q38073152Gene therapy for heart failure: where do we stand?
Q37015311Gene therapy for inborn errors of liver metabolism: progress towards clinical applications
Q40153924Gene therapy for laryngeal paralysis
Q37346064Gene therapy for liver enzyme deficiencies: what have we learned from models for Crigler-Najjar and tyrosinemia?
Q37781788Gene therapy for liver regeneration: experimental studies and prospects for clinical trials.
Q36226708Gene therapy for malignant glioma: current clinical status
Q45877752Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.
Q33881920Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.
Q35160142Gene therapy for ocular diseases
Q37952287Gene therapy for rheumatoid arthritis: current status and future prospects
Q26851920Gene therapy for the inner ear
Q35340196Gene therapy for the nervous system: challenges and new strategies
Q36541946Gene therapy for transplantation with viral vectors--how much of the promise has been realised?
Q38213212Gene therapy in India: a focus
Q83797705Gene therapy in transplantation
Q38243641Gene therapy modalities in lung transplantation.
Q36922247Gene therapy of gynaecological diseases
Q37207021Gene therapy of the rheumatic diseases: 1998 to 2008.
Q27007012Gene therapy on the move
Q38654544Gene therapy research in Asia
Q37515656Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer
Q37786559Gene therapy to the kidney using viral vectors
Q41807910Gene therapy, early promises, subsequent problems, and recent breakthroughs.
Q27000091Gene therapy: light is finally in the tunnel
Q37109090Gene therapy: some history, applications, problems, and prospects
Q36464907Gene transfer approaches for gynecological diseases
Q37506503Gene-based therapies in Parkinson's disease
Q35620919Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.
Q34830129Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.
Q38920465Genetic diseases, immunology, viruses, and gene therapy
Q42752947Genetic engineering in athletes
Q36423907Genetic medicines: treatment strategies for hereditary disorders
Q36288888Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects
Q24595921Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology
Q35925455Genetically engineered immune privileged Sertoli cells: A new road to cell based gene therapy
Q41928233Genome engineering: a new approach to gene therapy for neuromuscular disorders.
Q33781719Genomic and bioinformatics analysis of HAdV-4, a human adenovirus causing acute respiratory disease: implications for gene therapy and vaccine vector development
Q45880712Genomic and bioinformatics analysis of HAdV-7, a human adenovirus of species B1 that causes acute respiratory disease: implications for vector development in human gene therapy
Q36453658Genotoxicity of retroviral integration in hematopoietic cells.
Q37816955Getting arthritis gene therapy into the clinic
Q52314492Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects.
Q26797520Going viral: a review of replication-selective oncolytic adenoviruses
Q36793856Haemophilia A: molecular insights.
Q37582126Helper-Dependent Adenoviral Vectors.
Q38302375Helper-dependent adenoviral vectors for liver-directed gene therapy of primary hyperoxaluria type 1.
Q36219334Helper-dependent adenoviral vectors in experimental gene therapy.
Q33775537Hepatic gene transfer as a means of tolerance induction to transgene products
Q38712985Hepatocyte growth factor in dampening liver immune-mediated pathology in acute viral hepatitis without compromising antiviral activity.
Q38025743Hepatocyte transplantation for inherited metabolic diseases of the liver.
Q36685593High-level secretion of growth hormone by retrovirally transduced primary human keratinocytes: prospects for an animal model of cutaneous gene therapy.
Q42410618How to design a cell or gene therapy clinical trial: advice from the FDA.
Q92204445How to discuss gene therapy for haemophilia? A patient and physician perspective
Q90677465How will the field of gene therapy survive its success?
Q36672262Human artificial chromosome vectors meet stem cells: new prospects for gene delivery
Q38183464Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology
Q35238272Human artificial chromosomes for gene delivery and the development of animal models
Q44943174Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice
Q35194441Hyaluronan-CD44 interactions as potential targets for cancer therapy.
Q33794201Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.
Q40051551Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava
Q38061510IL-12 based gene therapy in veterinary medicine
Q35126751IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
Q37291653Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Q38008337Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm
Q42861412Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors
Q36983740Immune responses to AAV vectors: overcoming barriers to successful gene therapy
Q37245006Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain
Q35882794Immunosuppressive exosomes: a new approach for treating arthritis
Q39117333Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques
Q37945219Improving adenovirus based gene transfer: strategies to accomplish immune evasion
Q90211358In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies
Q54204523In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium.
Q44115042In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
Q36105888In utero gene therapy: current challenges and perspectives.
Q39793497In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms
Q45889022In vivo gene transfer to healthy and diabetic canine pancreas.
Q37394036In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors
Q37416925Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
Q35939486Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin
Q43994130Increased hepatic transduction with reduced systemic dissemination and proinflammatory cytokines following hydrodynamic injection of helper-dependent adenoviral vectors.
Q33977026Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy.
Q92999056Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus
Q33608746Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cells
Q36052188Influence of cationic lipid concentration on properties of lipid-polymer hybrid nanospheres for gene delivery
Q39502394Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors
Q36237308Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model
Q34621683Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression
Q37499424Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus
Q33805229Innate immune recognition of viruses and viral vectors
Q41453719Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5.
Q35785201Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
Q26997318Inner ear symptoms and disease: pathophysiological understanding and therapeutic options
Q37329603Insights into adenovirus host cell interactions from structural studies
Q39226100Institutional Oversight of Occupational Health and Safety for Research Programs Involving Biohazards
Q58199420Integration of ER stress and viral nucleotide sensing in DCs: Mounting a response commensurate to the threat?
Q39532576Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors
Q27021261Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer
Q37082190Interception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users
Q39651137Internalization and biodistribution of polymersomes into oral squamous cell carcinoma cells in vitro and in vivo
Q45862100Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice
Q37050672Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir
Q54364641Intravenous injection of irradiated tumor cell vaccine carrying oncolytic adenovirus suppressed the growth of multiple lung tumors in a mouse squamous cell carcinoma model.
Q45863402Introducing Genes to the Heart: All About Delivery
Q99573751In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model
Q37082159Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point
Q27318346Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
Q36333340Large animal models and gene therapy
Q37778403Leptin gene therapy in the fight against diabetes
Q45883135Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency
Q37784661Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies
Q30801455Lipoplex structures and their distinct cellular pathways.
Q50763331Liver transplantation for urea cycle disorders in pediatric patients: a single-center experience.
Q37692647Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects
Q45862703Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis
Q64378421Local delivery of a viral vector mitigates neutralization by antiviral antibodies and results in efficient transduction of rabbit liver
Q53510432Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.
Q45858049Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.
Q45036081Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus
Q51864807Long-term outcome following pediatric liver transplantation for metabolic disorders.
Q38544793Lung gene therapy-How to capture illumination from the light already present in the tunnel
Q45125275Luteinizing hormone plasmid therapy results in long-lasting high circulating Lh and increased sperm production in European sea bass (Dicentrarchus labrax).
Q39593763Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome.
Q37148646Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells
Q35952192Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells
Q38822218Management of knee osteoarthritis. Current status and future trends
Q37984486Manipulation of adenovirus interactions with host factors for gene therapy applications
Q33275292Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells
Q37106639Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets
Q33581506Mechanisms of nanoparticle-mediated siRNA transfection by melittin-derived peptides
Q33684461Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions.
Q33393397Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses
Q36788494Medical treatment of pancreatic cancer
Q34676808Mesenchymal stem cells at the intersection of cell and gene therapy
Q37310677Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model
Q26741958Methods of Genome Engineering: a New Era of Molecular Biology
Q38612545Microbubbles and Ultrasound: Therapeutic Applications in Diabetic Nephropathy
Q37395452Microcalorimetry: a response to challenges in modern biotechnology.
Q40202250Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver
Q35911766Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes
Q90549130Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing
Q37092541Modification of Schwann cell gene expression by electroporation in vivo
Q63928518Modified ARCA analogs providing enhanced translational properties of capped mRNAs
Q98614074Modified mRNA as a Therapeutic Tool for the Heart
Q33371239Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors
Q37799373Molecular Mechanisms and Treatment Options for Muscle Wasting Diseases
Q36932523Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection
Q34667746Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism
Q37241328Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice
Q40075764Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes
Q38533753Neprilysin gene transfer: A promising therapeutic approach for Alzheimer's disease
Q36356874Neurotrophic factor-secreting autologous muscle stem cell therapy for the treatment of laryngeal denervation injury
Q53262613New frontiers in hereditary metabolic disease: an historical perspective.
Q50056861New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
Q58728426Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers
Q37094072Nonmuscle invasive bladder cancer: a primer on immunotherapy.
Q42615111Nonviral delivery of basic fibroblast growth factor gene to bone marrow stromal cells
Q35608449Novel adenovirus detected in captive bottlenose dolphins (Tursiops truncatus) suffering from self-limiting gastroenteritis.
Q36014074Novel therapies, high-risk pediatric research, and the prospect of benefit: learning from the ethical disagreements
Q35260938Novel viral vector systems for gene therapy.
Q33863665Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells
Q52429666Nuclease-Mediated Gene Therapies for Inherited Metabolic Diseases of the Liver.
Q60930832Nucleic acids and analogs for bone regeneration
Q37687415Oncolytic (replication-competent) adenoviruses as anticancer agents.
Q36318189Oncolytic adenoviruses - selective retargeting to tumor cells
Q35613158Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells
Q35870480Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro
Q35666180Optimized adenovirus-antibody complexes stimulate strong cellular and humoral immune responses against an encoded antigen in naive mice and those with preexisting immunity
Q33732824Optimizing cationic and neutral lipids for efficient gene delivery at high serum content
Q28476268Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems
Q37880689Organ targeted prenatal gene therapy--how far are we?
Q40608919Orthopedic gene therapy--lost in translation?
Q42281690PEGylated helper-dependent adenoviral vector expressing human Apo A-I for gene therapy in LDLR-deficient mice
Q33364520PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile
Q34860648Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice.
Q38714311Pathology in Permissive Syrian Hamsters after Infection with Species C Human Adenovirus (HAdV-C) Is the Result of Virus Replication: HAdV-C6 Replicates More and Causes More Pathology than HAdV-C5
Q30394255Patient-Specific Therapy via Cell-Reprogramming Technology: a Curative Potential for Patients with Diabetes
Q37347451Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems
Q35864258Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity.
Q39004582Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers.
Q37398067Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors
Q42193828Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor
Q38012709Phoenix rising: gene therapy makes a comeback
Q40510393Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference material
Q33831381Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice
Q36902844Potential use of gene transfer in athletic performance enhancement.
Q38284700Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important?.
Q64989716Precision gene editing technology and applications in nephrology.
Q45868822Preclinical evaluation of gene delivery methods for the treatment of loco-regional disease in breast cancer
Q37399961Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood
Q57170242Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus
Q56564487Prenatal gene therapy for the early treatment of genetic disorders
Q36994170Progress and prospects: gene therapy clinical trials (part 2).
Q26781432Progresses towards safe and efficient gene therapy vectors
Q33388660Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors
Q96306729Prospects for Cell-Directed Curative Therapy of Phenylketonuria (PKU)
Q40462830Prospects for cell-based therapy.
Q35824841Prospects for gene therapy of haemophilia
Q37082158Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse
Q36779377Prostate cancer gene therapy clinical trials
Q45865772Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy.
Q37847687Pulmonary delivery of therapeutic siRNA.
Q35187635Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells
Q35069550Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Q63740735RNA Viruses as Tools in Gene Therapy and Vaccine Development
Q36803909Radionuclide reporter gene imaging for cardiac gene therapy
Q36878392Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function
Q27487857Recent Developments in Peptide-Based Nucleic Acid Delivery
Q89775505Recent advances in genome editing for cardiovascular disease
Q33709989Recent developments in gene transfer: risk and ethics
Q38017202Recent developments in transposon-mediated gene therapy
Q34080884Recognition of virus infection and innate host responses to viral gene therapy vectors
Q38907797Recombinant Adeno-Associated Viral Integration and Genotoxicity: Insights from Animal Models.
Q35772588Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer
Q37968572Regenerative nanomedicine and the treatment of degenerative retinal diseases
Q35847459Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model
Q34233124Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Q36948756Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
Q35575680Regulatory and ethical issues for phase I in utero gene transfer studies
Q41161224Reprogramming of mice primary hepatocytes into insulin-producing cells by transfection with multicistronic vectors.
Q35210756Republished review: Gene therapy for ocular diseases
Q34757960Rescuing the failing heart by targeted gene transfer
Q38974025Rethinking risk assessment for emerging technology first-in-human trials
Q40527438Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer
Q35224065SR-A and SREC-I binding peptides increase HDAd-mediated liver transduction.
Q46764500Safety assessment of intraportal liver cell application in New Zealand white rabbits under GLP conditions
Q39809796Safety studies on an adenovirus recombinant vaccine for rabies (AdRG1.3-ONRAB) in target and non-target species
Q34218552Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease
Q38920000Sendai virus-mediated gene transfer of the c-myc suppressor far-upstream element-binding protein-interacting repressor suppresses head and neck cancer.
Q37945193Serotype chimeric human adenoviruses for cancer gene therapy
Q58806285Sertoli Cells Engineered to Express Insulin to Lower Blood Glucose in Diabetic Mice
Q47353872Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
Q49600921Severe toxicity in nonhuman primates and piglets following high-dose intravenous administration of an AAV vector expressing human SMN.
Q27347215Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator
Q45875060Shutdown of immunological priming and presentation after in vivo administration of adenovirus
Q90349121Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research
Q30430739Sonoporation: Gene transfer using ultrasound
Q42585087Special Issue: Gene Therapy with Emphasis on RNA Interference
Q34975214Species differences in the pharmacology and toxicology of PEGylated helper-dependent adenovirus
Q38124263Stem cells for cardiac repair: an introduction
Q36675446Strategies to achieve systemic delivery of therapeutic cells and microbes to tumors
Q37503253Strategies to overcome host immunity to adenovirus vectors in vaccine development
Q45866314Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy
Q91322683Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization
Q35874710Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.
Q33826170Sustained expression of insulin by a genetically engineered sertoli cell line after allotransplantation in diabetic BALB/c mice
Q34864807Synergetic Targeted Delivery of Sleeping-Beauty Transposon System to Mesenchymal Stem Cells Using LPD Nanoparticles Modified with a Phage-Displayed Targeting Peptide
Q42137029Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery
Q57039821Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy
Q34132297Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland.
Q38295808TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector
Q40295059TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.
Q33785096TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses.
Q37209562Targeted gene insertion for molecular medicine
Q50056652Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency
Q64039369Targeting a Pre-existing Anti-transgene T Cell Response for Effective Gene Therapy of MPS-I in the Mouse Model of the Disease
Q39298850Telomerase-specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice
Q27653315The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution
Q53065419The Death of Jesse Gelsinger: New Evidence of the Influence of Money and Prestige in Human Research
Q34975228The challenge for gene therapy: innate immune response to adenoviruses
Q47910262The ethics of human gene transfer
Q38189250The evolution of adenoviral vectors through genetic and chemical surface modifications
Q30053630The evolution of gene therapy in X-linked severe combined immunodeficiency
Q34132804The future potential for cocaine vaccines
Q34220590The potential of nanomedicine therapies to treat neovascular disease in the retina.
Q36674594The role of Rds in outer segment morphogenesis and human retinal disease
Q37998186The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury.
Q45144005The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
Q41627004The spread of adenoviral vectors to central nervous system through pathway of cochlea in mimetic aging and young rats
Q45873891Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury
Q34982869Therapeutic approaches to muscular dystrophy.
Q37866086Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
Q45886566Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats
Q92749886Therapeutic potential of CRISPR/Cas9 gene editing in engineered T-cell therapy
Q37809086Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators
Q36549699Therapeutic restoration of dystrophin expression in Duchenne muscular dystrophy.
Q36066048Therapy for haemophilia: recent advances and goals for the future
Q37274356Tissue engineering for bone defect healing: an update on a multi-component approach
Q35779378Tissue-specific promoters for cancer gene therapy
Q33633293Toward Personalized Gene Therapy: Characterizing the Host Genetic Control of Lentiviral-Vector-Mediated Hepatic Gene Delivery
Q45858373Toward gene therapy for hemophilia A with novel adenoviral vectors: successes and limitations in canine models
Q44104372Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Q53826123Transduction Properties of Adenovirus Serotype 35 Vectors After Intravenous Administration Into Nonhuman Primates.
Q51766318Transfection of cells using flow-through electroporation based on constant voltage.
Q37077838Transfer of human artificial chromosome vectors into stem cells
Q40225778Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters
Q42223027Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver
Q47697784Transplantation as disease modifying therapy in adults with inherited metabolic disorders
Q37714129Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice
Q34183436Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.
Q40297448Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells
Q33654083Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging
Q38181868Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases
Q35240986Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage
Q26786070Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery
Q30433085V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy
Q44236123Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice
Q36780050Vectors for airway gene delivery
Q35665175Verapamil results in increased blood levels of oncolytic adenovirus in treatment of patients with advanced cancer
Q39149034Viral Vector Biosafety in Laboratory Animal Research
Q26741952Viral Vectors for Gene Therapy: Current State and Clinical Perspectives
Q55408780Viral Vectors in Gene Therapy.
Q34315475Viral and nonviral delivery systems for gene delivery
Q37687420Viral vector-mediated gene transfer for CNS disease
Q37262766Viral vectors: from virology to transgene expression
Q42579980Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
Q35260293Virus infection recognition and early innate responses to non-enveloped viral vectors
Q39594815Visualization of intracellular trafficking of Math1 protein in different cell types with a newly-constructed nonviral gene delivery plasmid
Q58554739Whatever happened to the Shwartzman phenomenon?
Q53320095[Clinical application of gene therapy. Previous experience and the future].
Q37035388microRNAs: a new emerging class of players for disease diagnostics and gene therapy
Q40053389piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
Q40035650siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
Q37679521β-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon

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