Heat-shock protein 70 antagonizes apoptosis-inducing factor

scientific article (publication date: September 2001)

Heat-shock protein 70 antagonizes apoptosis-inducing factor is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1036269889
P356DOI10.1038/NCB0901-839
P3181OpenCitations bibliographic resource ID2748285
P698PubMed publication ID11533664
P5875ResearchGate publication ID11811996

P50authorJosef PenningerQ1674391
Marja JäätteläQ19507915
Guido KroemerQ19508945
Eric DaugasQ42889813
P2093author name stringN Zamzami
S A Susin
L Ravagnan
C Garrido
M Jäättelä
T Mak
S Gurbuxani
C Maisse
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Two distinct pathways leading to nuclear apoptosisQ24676123
Negative regulation of the Apaf-1 apoptosome by Hsp70Q28143100
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell deathQ28209183
Apaf1 is required for mitochondrial pathways of apoptosis and brain developmentQ28505574
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.Q33889765
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeQ33912989
Hsp27 negatively regulates cell death by interacting with cytochrome c.Q33917298
Role of the heat shock response and molecular chaperones in oncogenesis and cell deathQ34052682
Stress management - heat shock protein-70 and the regulation of apoptosisQ34123289
Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinaseQ34271504
Heat stress induces hsc70/nuclear topoisomerase I complex formation in vivo: evidence for hsc70-mediated, ATP-independent reactivation in vitroQ35071715
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.Q35170422
Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.Q36364876
Bcl-2 inhibits the mitochondrial release of an apoptogenic proteaseQ36367392
Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.Q36368462
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.Q36376051
Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domainQ36876655
Expression of human HSP70 during the synthetic phase of the cell cycleQ37411456
Mitochondria are selective targets for the protective effects of heat shock against oxidative injuryQ37523837
Natural resistance of human beta cells toward nitric oxide is mediated by heat shock protein 70.Q40888704
ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosisQ40918013
Oncogenic potential of Hsp72.Q40946361
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factorQ57185203
HSP27 and HSP70 increase the survival of WEHI-S cells exposed to hyperthermiaQ59487875
Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T CellsQ62082005
T cell lymphoma in transgenic mice expressing the human Hsp70 geneQ70900735
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)839-43
P577publication date2001-09-01
P1433published inNature Cell BiologyQ1574111
P1476titleHeat-shock protein 70 antagonizes apoptosis-inducing factor
P478volume3

Reverse relations

cites work (P2860)
Q4292446015-deoxyspergualin inhibits eukaryotic protein synthesis through eIF2alpha phosphorylation
Q89861839A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death
Q85093395A new form of cell death: Parthanatos
Q24301950A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)
Q37339375A role for HSP70 in protecting against indomethacin-induced gastric lesions
Q33344300A time-course comparative microarray analysis of an incompatible and compatible response by Glycine max (soybean) to Heterodera glycines (soybean cyst nematode) infection
Q40600452AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis
Q46859342AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer.
Q35868063Adult neuron survival strategies--slamming on the brakes
Q37695219Alcohol stress, membranes, and chaperones
Q37713099Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001.
Q34066549Amyotrophic lateral sclerosis: a proposed mechanism
Q39937441An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death
Q40009236Analysis of cell surface and relative gene expression of heat shock protein 70 in human leukemia cell lines
Q58715274Anastasis: recovery from the brink of cell death
Q77378499Another genotoxic agent released by mitochondrial meltdown
Q44764330Anti-hypoxia effect of adenovirus-mediated expression of heat shock protein 70 (HSP70) on primary cultured neurons
Q33799516Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules
Q48077559Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells
Q35603092Anticancer therapy targeting the apoptotic pathway
Q35146577Apoptosis and melanoma chemoresistance
Q35928799Apoptosis and porcine reproductive and respiratory syndrome virus
Q36052709Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms
Q37375811Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27
Q55265243Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer.
Q24313294Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g)
Q28218562Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria
Q40529847Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
Q48397448Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.
Q34987223Apoptosis-inducing factor: structure, function, and redox regulation
Q36226739Apoptotic pathways and therapy resistance in human malignancies
Q36194579Arsenic trioxide: an anti cancer missile with multiple warheads.
Q44662327BAG3 protein regulates stress-induced apoptosis in normal and neoplastic leukocytes
Q33530053Bicyclol protects HepG2 cells against D-galactosamine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway
Q36988138Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance
Q34569825Caloric restriction and intermittent fasting: two potential diets for successful brain aging
Q90325452Camel whey protein enhances lymphocyte survival by modulating the expression of survivin, bim/bax, and cytochrome C and restores heat stress-mediated pathological alteration in lymphoid organs
Q35569164Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats.
Q38870039Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
Q40632803Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage
Q34609532Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblasts
Q33674213Cellular stress responses: cell survival and cell death
Q34569580Changes in HSP gene and protein expression in natural scrapie with brain damage
Q50720065Changes in gravitational force cause changes in gene expression in the lens of developing zebrafish.
Q37119895Chaperoning erythropoiesis.
Q35026496Chemotherapy: targeting the mitochondrial cell death pathway
Q44759289Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.
Q38248009Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression
Q34179630Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia
Q39557740Co-inhibition of HSP70/HSP90 synergistically sensitizes nasopharyngeal carcinoma cells to thermotherapy
Q89620035Comparative Transcriptome Analysis of the Heat Stress Response in Monochamus alternatus Hope (Coleoptera: Cerambycidae)
Q33183742Comparative genomic hybridization analysis of sperm DNA apoptosis after exposure to heat shock
Q37584499Comparative proteomic analysis of liver antioxidant mechanisms in Megalobrama amblycephala stimulated with dietary emodin
Q35210599Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme
Q44555677Copper impact on heat shock protein 70 expression and apoptosis in rainbow trout hepatocytes
Q33287149Correlation of malignant phenotypes of human tumour cell lines with augmented expression of Hsp72 protein measured by laser scanning cytometry
Q40219092CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation
Q44246409Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis
Q36296163Death penalty for keratinocytes: apoptosis versus cornification.
Q36274956Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
Q48228417Decreased temperature as a signal for regulation of heat shock protein expression in anoxic brain and heart: focus on "Expression of heat shock proteins in anoxic crucian carp (Carassius carassius): support for cold as a preparatory cue for anoxia".
Q35007926Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators
Q52745734Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats.
Q42266564Different changes in mitochondrial apoptotic pathway in lymphocytes and granulocytes in cirrhotic patients with sepsis.
Q33694521Differential heat shock protein localization in chronic lymphocytic leukemia
Q44331776Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation
Q51584140Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP.
Q42705225Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone hsp70.
Q37355391Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells
Q42003277Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients
Q47318003Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets
Q41882390Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma
Q41035706Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress
Q57497558Emodin induces liver injury by inhibiting the key enzymes of FADH/NADPH transport in rat liver
Q37976136Endothelial cells and magnesium: implications in atherosclerosis
Q84514479Endurance training accelerates exhaustive exercise-induced mitochondrial DNA deletion and apoptosis of left ventricle myocardium in rats
Q36161877Environmental toxins and alpha-synuclein in Parkinson's disease
Q33229631Evaluation of ST13 gene expression in colorectal cancer patients
Q33736465Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.
Q34277084Expression profile of genes as indicators of developmental competence and quality of in vitro fertilization and somatic cell nuclear transfer bovine embryos
Q92987534Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones
Q37461604Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest
Q33811254Geldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells
Q48494250Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
Q34540789Genetic analysis of the mammalian cell death machinery
Q92997887Genomewide identification and analysis of heat-shock proteins 70/110 to reveal their potential functions in Chinese soft-shelled turtle Pelodiscus sinensis
Q30482715Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features
Q38340918Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis
Q38318251Global changes in STAT target selection and transcription regulation upon interferon treatments
Q39967040HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer
Q89978558HSP70 Multi-Functionality in Cancer
Q46949098HSP70 and EndoG modulate cell death by heat in human skin keratinocytes in vitro
Q45182331HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis
Q37062084HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Q39978610HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma
Q33975891HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.
Q28202861HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells
Q21145793HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
Q26778548HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms
Q40352898Ha-ras(val12) induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-ras(val12)-transformed cells
Q40079905Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL.
Q36834709Heat shock genes - integrating cell survival and death
Q44077103Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes
Q58694884Heat shock pretreatment of mesenchymal stem cells for inhibiting the apoptosis of ovarian granulosa cells enhanced the repair effect on chemotherapy-induced premature ovarian failure
Q34756155Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase
Q33956906Heat shock protein 70 (hsp70) as an emerging drug target.
Q38222563Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia?
Q36201174Heat shock protein 70 and the acute respiratory distress syndrome
Q40626779Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.
Q34195771Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells
Q40191875Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis
Q42971215Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
Q42252886Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.
Q87423764Heat shock protein 70 kDa (HSP70) increase in sea bass (Dicentrarchus labrax, L 1758) thymus after vaccination against Listonella anguillarum
Q35762499Heat shock protein 90 inhibition in lung cancer
Q42142400Heat shock protein and apoptosis in supraspinatus tendinopathy.
Q36889463Heat shock protein expression in brain: a protective role spanning intrinsic thermal resistance and defense against neurotropic viruses
Q24537720Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1.
Q35179760Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease
Q40019335Heat shock proteins and Bcl-2 expression and function in relation to the differential hyperthermic sensitivity between leukemic and normal hematopoietic cells
Q28272905Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
Q38008726Heat shock proteins in cancer: targeting the 'chaperones'.
Q38199919Heat shock proteins in multiple myeloma
Q30414556Heat shock proteins in neurodegenerative disorders and aging
Q35120739Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways
Q37081794Heat shock proteins: essential proteins for apoptosis regulation
Q39229625Heat shock transcription factor-1 suppresses apoptotic cell death and ROS generation in 3-nitropropionic acid-stimulated striatal cells
Q40710834Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells
Q51708353Heat stress protects against mechanical ventilation-induced diaphragmatic atrophy.
Q28512499Heat-shock protein 70 attenuates nitric oxide-induced apoptosis in RAW macrophages by preventing cytochrome c release
Q37037631Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling
Q45178235Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease
Q40371434Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation
Q33716832Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival
Q46021081Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.
Q34510989Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling
Q24336627Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Q39002626Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice.
Q50659448Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun.
Q53150253Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3.
Q27012978Hsp70.1 and related lysosomal factors for necrotic neuronal death
Q47362469Hsp70: A Cancer Target Inside and Outside the Cell
Q37490096Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells.
Q45061733Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.
Q35216158Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells
Q44359934Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases
Q37328256Hydrogen sulfide mediates cardioprotection through Nrf2 signaling
Q40153288Hyperthermia enhances tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human cancer cells
Q42156818Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction.
Q34764251Identification of a testis-enriched heat shock protein and fourteen members of Hsp70 family in the swamp eel.
Q28271233Immune response against dying tumor cells
Q39178654Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?
Q36497735Impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation
Q51166052Impact of simulated microgravity on cell cycle control and cytokine release by U937 cells.
Q41613535Increase in DNA fragmentation and apoptosis-related gene expression in frozen-thawed bovine blastocysts
Q50731614Increased DNA fragmentation and altered apoptotic protein levels in skeletal muscle of spontaneously hypertensive rats.
Q73801980Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels
Q84096707Increased intracellular, cell surface, and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC
Q34690883Increased stability of Bcl-2 in HSP70-mediated protection against apoptosis induced by oxidative stress
Q40383650Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice
Q40601130Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes
Q34451153Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors
Q38161378Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity
Q34515624Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
Q44644554Intensified oxidative and nitrosative stress following combined ALA‐based photodynamic therapy and local hyperthermia in rat tumors
Q41901427Interleukin-1 receptor-mediated inflammation impairs the heat shock response of human mesothelial cells.
Q43207277Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos
Q40235382Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70.
Q21245636Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry
Q33495179Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis
Q40729124Involvement of microtubules and mitochondria in the antagonism of arsenic trioxide on paclitaxel-induced apoptosis
Q39612604KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia
Q36111475Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells.
Q33194237Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.
Q33292705Laser capture microdissection (LCM) and comparative microarray expression analysis of syncytial cells isolated from incompatible and compatible soybean (Glycine max) roots infected by the soybean cyst nematode (Heterodera glycines).
Q43657650Liver and skeletal muscle mitochondria proteomes are altered in pigs divergently selected for residual feed intake
Q35887873Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture.
Q44456085MPTP-induced reactive oxygen species promote cell death through a gradual activation of caspase-3 without expression of GRP78/Bip as a preventive measure against ER stress in PC12 cells
Q39429252Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis
Q36468900Mechanisms of cytochrome c release from mitochondria
Q36045199Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies
Q39283652Melatonin ameliorates the adverse effects of leptin on sperm
Q52761279Membrane heat shock protein 70: a theranostic target for cancer therapy.
Q36558028Mitochondria as therapeutic targets for cancer chemotherapy
Q27024426Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies
Q35492308Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion
Q34736668Mitochondria, the killer organelles and their weapons
Q35958998Mitochondrial and cytoskeletal alterations are involved in the pathogenesis of hydronephrosis in ICR/Mlac-hydro mice
Q33645577Mitochondrial and postmitochondrial survival signaling in cancer.
Q35637415Mitochondrial effectors in caspase-independent cell death
Q51025917Mitochondrial functions during cell death, a complex (I–V) dilemma
Q35120732Mitochondrial intermembrane proteins in cell death
Q40698828Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis
Q38768778Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work
Q47963008Mitochondrial respiratory deficiencies signal up-regulation of genes for heat shock proteins
Q42770281Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.
Q34711201Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior
Q26739428Modulation of Alloimmunity by Heat Shock Proteins
Q40549297Modulation of cell functions of human tendon fibroblasts by different repetitive cyclic mechanical stress patterns
Q37799850Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics
Q35197096Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Q34441815Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.
Q33715640Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies
Q37310205Molecular chaperones as regulators of cell death
Q35688796Molecular chaperones in Parkinson's disease--present and future
Q37002804Molecular characteristics of immunogenic cancer cell death.
Q24297933Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis
Q33346818Molecular imaging-assisted optimization of hsp70 expression during laser-induced thermal preconditioning for wound repair enhancement
Q34516626Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.
Q37056974Molecular physiology of preconditioning-induced brain tolerance to ischemia
Q42719727Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone
Q35092234Natural cellular inhibitors of caspases
Q42096021Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation
Q40389152Neuroprotective effects of virally delivered HSPs in experimental stroke
Q33709375Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats
Q41084030Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.
Q35770711Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation
Q34020316Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells
Q33830124Novel insights into hydrogen sulfide--mediated cytoprotection.
Q38961037Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells.
Q31120475Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis
Q28565594Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress
Q37172898OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells
Q89578938Oncosis-inducing cyclometalated iridium(iii) complexes
Q34443559Organelle-specific initiation of cell death pathways
Q39293881Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Q34703681Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress.
Q34335567Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
Q45960007Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia.
Q44633150Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures
Q39647346Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells
Q35670138Parthanatos, a messenger of death
Q35192354Pathways of cell signaling in hyperoxia
Q40346972Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection
Q26853192Photoreceptor cell death and rescue in retinal detachment and degenerations
Q48702080Physical interaction of apoptosis-inducing factor with DNA and RNA.
Q39857996Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.
Q39062053Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells
Q40100988Placental Malaria: A New Insight into the Pathophysiology
Q37426834Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos
Q44323344Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway
Q39930338Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity.
Q35023242Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model
Q34284039Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?
Q39828632Prediction of localization and interactions of apoptotic proteins.
Q33950514Prediction of protease substrates using sequence and structure features
Q48631093Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia
Q38036233Programmed cell death in Parkinson's disease
Q52118783Programmed cell death in the neurulating embryo is prevented by the chaperone heat shock cognate 70.
Q40122416Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions
Q41868997Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes
Q34667877Protective effects of transforming growth factor β2 in intestinal epithelial cells by regulation of proteins associated with stress and endotoxin responses.
Q40700039Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection.
Q37185032Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression
Q38818403Protein-based therapeutic for anemia caused by dyserythropoiesis.
Q35205950Proteins implicated in mediating self-incompatibility-induced alterations to the actin cytoskeleton of Papaver pollen
Q91636622Proteomic analysis of xylem vessel cell differentiation in VND7-inducible tobacco BY-2 cells by two-dimensional gel electrophoresis
Q35725189Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs
Q35438034Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress
Q27655498Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor
Q46155629Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor
Q36923921Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70
Q39757062Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells
Q35108820Role of Apoptotic Proteins in REC-2006 Mediated Radiation Protection in Hepatoma Cell Lines
Q38951024Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury model in vitro
Q35955745Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress
Q35764321Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis
Q47237527Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer
Q38256778Roles of obese-insulin resistance and anti-diabetic drugs on the heart with ischemia-reperfusion injury
Q64094645SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF
Q45047581Salicylic acid-mediated potentiation of Hsp70 induction correlates with reduced apoptosis in tobacco protoplasts
Q40762454Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells
Q40006395Sequestration of NF-kappaB signaling complexes in lipid rafts contributes to repression of NF-kappaB in T lymphocytes under hyperthermia stress
Q36700050Serum proteome analysis for profiling protein markers associated with carcinogenesis and lymph node metastasis in nasopharyngeal carcinoma
Q43226582Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases
Q51537754Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.
Q35801881Small molecule activators of the heat shock response and neuroprotection from stroke
Q38321287Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells
Q24306404Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria
Q92703174Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects
Q24813707Studies on substantially increased proteins in follicular fluid of bovine ovarian follicular cysts using 2-D PAGE and MALDI-TOF MS.
Q40629513Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells
Q34528825Survival in hostile environments: strategies of renal medullary cells
Q48853096Susceptibility to apoptosis varies with time in culture for murine neurons and astrocytes: changes in gene expression and activity.
Q34665121T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis
Q52546620Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones.
Q33758145Targeted disruption of hsp70.1 sensitizes to osmotic stress
Q41660505Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach
Q38742944Targeting Hsp70: A possible therapy for cancer
Q36379365Targeting chaperones in transformed systems--a focus on Hsp90 and cancer
Q28298397Targeting heat shock proteins in cancer
Q40027318Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.
Q50052866The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke
Q39703338The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid
Q36895403The HSP70 family and cancer
Q35138259The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.
Q92702584The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer
Q41470772The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma
Q24301022The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells
Q59800987The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration
Q37294853The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.
Q46324060The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitro
Q38173257The complex function of hsp70 in metastatic cancer.
Q42224288The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex
Q28071416The human HSP70 family of chaperones: where do we stand?
Q36890420The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma
Q30483242The influence of loud sound stress on expression of osmotic stress protein 94 in the murine inner ear
Q35683839The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
Q40060512The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action.
Q37689423The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma
Q38124247The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence
Q37516972The role of heat shock proteins in gastrointestinal diseases
Q34859478The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
Q89777415The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70
Q39343181The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines
Q38268859The virus-induced HSPs regulate the apoptosis of operatus APCs that result in autoimmunity, not in homeostasis
Q24626017Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
Q46425821Thermotolerance, oxidative stress, apoptosis, heat-shock proteins and damages to reproductive cells of insecticide-susceptible and -resistant strains of the diamondback moth Plutella xylostella
Q37644754Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells
Q24597133Two Hsp70 family members expressed in atherosclerotic lesions
Q39010794VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines
Q42024323VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity
Q42715572Zebrafish Hsp70 is required for embryonic lens formation
Q38942727mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells

Search more.