Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

scientific article published on 15 September 2004

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M401314200
P698PubMed publication ID15371421

P50authorChristine HawkinsQ43180756
Nicholas J ClemonsQ56997103
Robin L AndersonQ60683395
Rohan SteelQ80571605
P2093author name stringKatherine Buzzard
Judith P Doherty
P2860cites workhsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondriaQ24306768
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
X-linked IAP is a direct inhibitor of cell-death proteasesQ24318710
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspasesQ24532851
Negative regulation of the Apaf-1 apoptosome by Hsp70Q28143100
Heat-shock protein 70 antagonizes apoptosis-inducing factorQ28215084
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondriaQ28217828
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
Protein folding in the cellQ29547792
The heat-shock responseQ29619473
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Life-or-death decisions by the Bcl-2 protein family.Q31879227
Suicidal tendencies: apoptotic cell death by caspase family proteinasesQ33684353
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.Q33887189
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.Q33889765
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeQ33912989
An induced proximity model for caspase-8 activation.Q34065853
A new quantitative assay for cytochrome c release in apoptotic cells.Q34207175
Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosisQ34279049
Heat shock protein hsp70 accelerates the recovery of heat-shocked mammalian cells through its modulation of heat shock transcription factor HSF1.Q34569795
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cellsQ35088549
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuliQ35129790
Apoptosis-an introductionQ35206030
Ways of dying: multiple pathways to apoptosis.Q35560936
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells dieQ36322477
Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9Q36322518
A novel Apaf-1-independent putative caspase-2 activation complexQ36324314
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosisQ36571858
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 geneQ36918963
Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of bindingQ37541312
Effects of expressing human Hsp70 and its deletion derivatives on heat killing and on RNA and protein synthesisQ38297273
Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.Q39445072
Molecular chaperones in cellular protein foldingQ40540929
Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC.Q40629432
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilizationQ40708852
Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosomeQ40781034
Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cellsQ43722438
Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia.Q45960007
Heat shock protein 72 modulates pathways of stress-induced apoptosis.Q47921342
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.Q51091938
Heat shock-induced accumulation of 70-kDa stress protein (HSP70) can protect ATP-depleted tumor cells from necrosis.Q52540658
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
apoptotic processQ14599311
P1104number of pages10
P304page(s)51490-51499
P577publication date2004-09-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleHsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1
P478volume279

Reverse relations

cites work (P2860)
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