Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun.

scientific article published on 30 October 2007

Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1471-4159.2007.05006.X
P698PubMed publication ID17971127
P5875ResearchGate publication ID5875445

P2093author name stringY B Lee
A S Bienemann
J B Uney
J Howarth
P2860cites workCerebral glucose utilization in transgenic mice overexpressing heat shock protein 70 is altered by dizocilpineQ42519354
Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitroQ43697338
Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophyQ43903236
Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulationQ44331776
Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approachQ44872348
Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.Q45061733
HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosisQ45182331
Switching transgene expression in the brain using an adenoviral tetracycline-regulatable systemQ45887839
Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.Q46021081
The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitroQ46324060
Overexpression of hsp70i facilitates reactivation of intracellular proteins in neurones and protects them from denaturing stressQ48308851
The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulatorQ48610642
Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicityQ28143597
Heat-shock protein 70 antagonizes apoptosis-inducing factorQ28215084
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c releaseQ28567073
A cytoplasmic inhibitor of the JNK signal transduction pathwayQ28586970
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progressionQ31139684
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeQ33912989
Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinaseQ34271504
The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicityQ34654146
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrilsQ35169533
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosisQ36571858
Spatial analysis of cell death and Hsp70 induction in brain, thymus, and bone marrow of the hyperthermic rat.Q39958544
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocationQ40371434
Neuroprotective effects of virally delivered HSPs in experimental strokeQ40389152
Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosisQ40993382
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)271-278
P577publication date2007-10-30
P1433published inJournal of NeurochemistryQ6295643
P1476titleHsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun.
P478volume104

Reverse relations

cites work (P2860)
Q28266387Allostery in the Hsp70 chaperone proteins
Q36922834Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70
Q35898056C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons
Q46178162Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons.
Q36293649Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?
Q55260468DnaJ homolog subfamily A member1 (DnaJ1) is a newly discovered anti-apoptotic protein regulated by azadirachtin in Sf9 cells.
Q35870561Heat shock response and insulin-associated neurodegeneration
Q38161378Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity
Q36453021Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun
Q87251007Induction of phosphorylated c-Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration
Q34059530Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice
Q35911991Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy
Q47773940Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15.
Q45813546Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells.
Q47421684Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy.
Q42468678The effect of acute hypoxia on heat shock protein 72 expression and oxidative stress in vivo.

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