scholarly article | Q13442814 |
P50 | author | Nancy Rothwell | Q6962949 |
Pedro Mendes | Q7159862 | ||
Douglas Kell | Q5301676 | ||
Jürgen Pahle | Q57574724 | ||
Joshua Knowles | Q85348594 | ||
David Brough | Q38322302 | ||
Barry W McColl | Q41951687 | ||
Gloria López-Castejón | Q56441280 | ||
Ben G Small | Q57058402 | ||
Richard Allmendinger | Q57058412 | ||
P2860 | cites work | Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples | Q24289511 |
Physiological control of metabolic flux: the requirement for multisite modulation | Q24528216 | ||
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases | Q24606766 | ||
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat | Q28189196 | ||
Network pharmacology: the next paradigm in drug discovery | Q28297997 | ||
Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials | Q57305862 | ||
Mechanisms of drug combinations: interaction and network perspectives | Q83265745 | ||
COPD and co-morbidities, with special emphasis on cardiovascular conditions | Q83364375 | ||
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases | Q28388335 | ||
Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era | Q29398873 | ||
Global mapping of pharmacological space | Q29615876 | ||
Nonresolving inflammation | Q29616352 | ||
Biologic basis for interleukin-1 in disease | Q29619853 | ||
Combination chemical genetics | Q33378070 | ||
Cheminformatics approaches to analyze diversity in compound screening libraries. | Q33574187 | ||
Targeting the cancer kinome through polypharmacology | Q33893019 | ||
Multiobjective optimization in bioinformatics and computational biology | Q34624817 | ||
LPS/TLR4 signal transduction pathway | Q34756268 | ||
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm | Q34763799 | ||
A comprehensive map of the toll-like receptor signaling network | Q36494115 | ||
Multi-target therapeutics: when the whole is greater than the sum of the parts | Q36697412 | ||
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? | Q37097848 | ||
The value of drug repositioning in the current pharmaceutical market | Q37426297 | ||
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds | Q37536897 | ||
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy | Q37579967 | ||
"Go upstream, young man": lessons learned from the p38 saga | Q37649076 | ||
Systems approaches and algorithms for discovery of combinatorial therapies | Q37787998 | ||
Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape | Q38358691 | ||
Protein dynamics in drug combinations: a linear superposition of individual-drug responses | Q39731018 | ||
Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs. | Q39784255 | ||
Synergistic drug combinations tend to improve therapeutically relevant selectivity | Q39828335 | ||
The search for synergy: a critical review from a response surface perspective. | Q40417895 | ||
Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation | Q40862635 | ||
Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli | Q41493018 | ||
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice | Q42652064 | ||
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis | Q43044984 | ||
Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. | Q45966569 | ||
The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes | Q46748593 | ||
Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity. | Q51570119 | ||
Systems biology and combination therapy in the quest for clinical efficacy. | Q51934858 | ||
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy | Q57001135 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell biology | Q7141 |
inflammation | Q101991 | ||
P304 | page(s) | 902-8 | |
P577 | publication date | 2011-10-23 | |
P1433 | published in | Nature Chemical Biology | Q904026 |
P1476 | title | Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing | |
P478 | volume | 7 |
Q41861993 | A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs |
Q101051165 | A general strategy to control antibody specificity against targets showing molecular and biological similarity: Salmonella case study |
Q44286743 | A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy |
Q26766456 | A review on continuous-flow microfluidic PCR in droplets: Advances, challenges and future |
Q30658500 | A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines. |
Q36533947 | Age and sex related differences in subcortical brain iron concentrations among healthy adults |
Q41691779 | Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture |
Q36123974 | Diverse array-designed modes of combination therapies in Fangjiomics |
Q38914231 | Existing and Developing Approaches for QSAR Analysis of Mixtures. |
Q27332452 | Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models |
Q34646772 | Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. |
Q30433183 | High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells |
Q26775404 | Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology |
Q27144251 | Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery |
Q26781613 | Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives |
Q39270928 | Neighbor communities in drug combination networks characterize synergistic effect |
Q38093187 | Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles |
Q53698735 | No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases. |
Q50548393 | On handling ephemeral resource constraints in evolutionary search. |
Q35765830 | On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death |
Q61802954 | On-demand serum-free media formulations for human hematopoietic cell expansion using a high dimensional search algorithm |
Q30531785 | P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. |
Q37593264 | Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway |
Q26739684 | Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting |
Q28222668 | QSAR modeling: where have you been? Where are you going to? |
Q36522774 | Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors |
Q42135811 | Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments? |
Q27008867 | Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review |
Q38142061 | The role of inflammation and interleukin-1 in acute cerebrovascular disease |
Search more.