Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

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Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing is …
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scholarly articleQ13442814

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P356DOI10.1038/NCHEMBIO.689
P3181OpenCitations bibliographic resource ID4154589
P932PMC publication ID3223407
P698PubMed publication ID22020553
P5875ResearchGate publication ID51736064

P50authorNancy RothwellQ6962949
Pedro MendesQ7159862
Douglas KellQ5301676
Jürgen PahleQ57574724
Joshua KnowlesQ85348594
David BroughQ38322302
Barry W McCollQ41951687
Gloria López-CastejónQ56441280
Ben G SmallQ57058402
Richard AllmendingerQ57058412
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Systems approaches and algorithms for discovery of combinatorial therapiesQ37787998
Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscapeQ38358691
Protein dynamics in drug combinations: a linear superposition of individual-drug responsesQ39731018
Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs.Q39784255
Synergistic drug combinations tend to improve therapeutically relevant selectivityQ39828335
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Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activationQ40862635
Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuliQ41493018
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and miceQ42652064
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsisQ43044984
Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations.Q45966569
The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytesQ46748593
Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.Q51570119
Systems biology and combination therapy in the quest for clinical efficacy.Q51934858
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacyQ57001135
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
inflammationQ101991
P304page(s)902-8
P577publication date2011-10-23
P1433published inNature Chemical BiologyQ904026
P1476titleEfficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing
P478volume7

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