| scholarly article | Q13442814 |
| P50 | author | Douglas Kell | Q5301676 |
| P2860 | cites work | Defrosting the digital library: bibliographic tools for the next generation web. | Q21092568 |
| A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology | Q21147058 | ||
| Visualising biological data: a semantic approach to tool and database integration | Q21284356 | ||
| Gene ontology: tool for the unification of biology | Q23781406 | ||
| A protocol for generating a high-quality genome-scale metabolic reconstruction | Q24603373 | ||
| Evolutionary programming as a platform for in silico metabolic engineering | Q25257616 | ||
| In vitro selection of RNA molecules that bind specific ligands | Q27861109 | ||
| Statistical strategies for avoiding false discoveries in metabolomics and related experiments | Q27887473 | ||
| The automation of science. | Q27937312 | ||
| The evolutionary origin of complex features | Q28203090 | ||
| The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models | Q28212902 | ||
| Functional genomic hypothesis generation and experimentation by a robot scientist | Q28238856 | ||
| Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing | Q28251171 | ||
| The markup is the model: reasoning about systems biology models in the Semantic Web era | Q28259568 | ||
| Calling International Rescue: knowledge lost in literature and data landslide! | Q28265361 | ||
| Oscillations in NF-kappaB signaling control the dynamics of gene expression | Q28289121 | ||
| Network pharmacology: the next paradigm in drug discovery | Q28297997 | ||
| Controlled vocabularies and semantics in systems biology | Q28732715 | ||
| Integrating systems biology models and biomedical ontologies | Q28740525 | ||
| Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration | Q28741243 | ||
| Further developments towards a genome-scale metabolic model of yeast | Q28748223 | ||
| The art and practice of structure-based drug design: A molecular modeling perspective | Q29029768 | ||
| DENDRAL: A case study of the first expert system for scientific hypothesis formation | Q29387651 | ||
| Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era | Q29398873 | ||
| Reconstruction of biochemical networks in microorganisms | Q29616018 | ||
| 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries | Q30854803 | ||
| Chemistry. Shaped laser pulses as reagents | Q30883165 | ||
| Deciphering the reaction dynamics underlying optimal control laser fields | Q30883174 | ||
| Computational cluster validation in post-genomic data analysis | Q30990574 | ||
| Annuality, perenniality and cell death | Q33335199 | ||
| Flowering-time genes modulate meristem determinacy and growth form in Arabidopsis thaliana | Q33346301 | ||
| Evaluating the links between climate, disease spread, and amphibian declines | Q33382967 | ||
| Distilling free-form natural laws from experimental data | Q33426258 | ||
| Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides | Q33635299 | ||
| Bioinformatics challenges for genome-wide association studies | Q33647983 | ||
| Synergistic control of oscillations in the NF-kappaB signalling pathway | Q33999638 | ||
| Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha | Q34000346 | ||
| Event extraction for systems biology by text mining the literature | Q34122157 | ||
| Protein design is NP-hard | Q34163003 | ||
| ??? | Q28649301 | ||
| Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only | Q34188324 | ||
| Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation | Q34490423 | ||
| Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. | Q34584004 | ||
| Multiobjective optimization in bioinformatics and computational biology | Q34624817 | ||
| How to choose a good scientific problem | Q35005268 | ||
| Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation | Q35762068 | ||
| Automated reverse engineering of nonlinear dynamical systems | Q35840524 | ||
| Text mining and its potential applications in systems biology | Q36625511 | ||
| Multi-target therapeutics: when the whole is greater than the sum of the parts | Q36697412 | ||
| A decade of fragment-based drug design: strategic advances and lessons learned | Q36732253 | ||
| Bayesian methods in bioinformatics and computational systems biology | Q36790389 | ||
| Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? | Q37097848 | ||
| Systems approaches and algorithms for discovery of combinatorial therapies | Q37787998 | ||
| How to grow a mind: statistics, structure, and abstraction | Q37851773 | ||
| Systems metabolic engineering for chemicals and materials | Q37874348 | ||
| Analysis of a complete DNA-protein affinity landscape | Q38352043 | ||
| Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape | Q38358691 | ||
| Annotation of SBML models through rule-based semantic integration | Q38371927 | ||
| The virtual human: towards a global systems biology of multiscale, distributed biochemical network models | Q39819351 | ||
| Solvent selection for whole cell biotransformations in organic media. | Q40463302 | ||
| Intelligent software for laboratory automation | Q40486918 | ||
| Seeking a new biology through text mining | Q42220103 | ||
| Convergent evolution to an aptamer observed in small populations on DNA microarrays | Q42920087 | ||
| Predictive models for population performance on real biological fitness landscapes | Q43656975 | ||
| Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo | Q45876108 | ||
| Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. | Q45966569 | ||
| On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning. | Q45967378 | ||
| Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences | Q46855416 | ||
| The influence of drug-like concepts on decision-making in medicinal chemistry | Q46922861 | ||
| Visualisation and subsets of the chemical universe database GDB-13 for virtual screening | Q48057902 | ||
| Bayesian ranking of biochemical system models | Q48372148 | ||
| Comparison of genetic algorithms for experimental multi-objective optimization on the example of medium design for cyanobacteria. | Q51150466 | ||
| Rise of the robo scientists. | Q51609929 | ||
| Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics. | Q51925297 | ||
| Inference in Bayesian networks. | Q51956146 | ||
| Going places: forced and natural molecular evolution. | Q54582051 | ||
| Design and Analysis of Computer Experiments | Q56385613 | ||
| The Robot Scientist Adam | Q56784096 | ||
| Metabolic control theory: its role in microbiology and biotechnology | Q57393977 | ||
| Teaching lasers to control molecules | Q57555817 | ||
| Bayesian calibration of computer models | Q58852147 | ||
| Studying scientific discovery by computer simulation | Q81008847 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 236-244 | |
| P577 | publication date | 2012-01-18 | |
| P1433 | published in | BioEssays | Q4914614 |
| P1476 | title | Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments? | |
| P478 | volume | 34 |
| Q41861993 | A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs |
| Q29248210 | A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease |
| Q51751322 | A strategy for finding the optimal scale of plant core collection based on Monte Carlo simulation. |
| Q42365796 | Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin |
| Q28710543 | Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing |
| Q34646772 | Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. |
| Q92319719 | GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries |
| Q24273350 | How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion |
| Q60301695 | In silico engineering of metabolism reveals new biomarkers for increased biosurfactant production |
| Q26775404 | Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology |
| Q40255869 | Iterative refinement of a binding pocket model: active computational steering of lead optimization |
| Q37632332 | Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability |
| Q27144251 | Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery |
| Q26739684 | Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting |
| Q36145664 | SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution |
| Q35222433 | SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution |
| Q38287400 | Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently |
| Q30369734 | The virtue of innovation: innovation through the lenses of biological evolution |
| Q56876576 | Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting |
| Q59326826 | Understanding dynamics of coherent Ising machines through simulation of large-scale 2D Ising models |
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