Gene families: the taxonomy of protein paralogs and chimeras

scientific article

Gene families: the taxonomy of protein paralogs and chimeras is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1126/SCIENCE.278.5338.609
P3181OpenCitations bibliographic resource ID3090561
P698PubMed publication ID9381171
P5875ResearchGate publication ID235228679

P50authorTerri AttwoodQ10937
Shmuel PietrokovskiQ30362288
P2093author name stringS Henikoff
L Hood
P Bork
E A Greene
P433issue5338
P407language of work or nameEnglishQ1860
P304page(s)609-14
P577publication date1997-10-24
P1433published inScienceQ192864
P1476titleGene families: the taxonomy of protein paralogs and chimeras
P478volume278

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cites work (P2860)
Q35125571A complete inventory of fungal kinesins in representative filamentous ascomycetes
Q24807153A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes
Q40894552A member of the Plasmodium falciparum Pf60 multigene family codes for a nuclear protein expressed by readthrough of an internal stop codon
Q36747821A single intact ATPase site of the ABC transporter BtuCD drives 5% transport activity yet supports full in vivo vitamin B12 utilization
Q57211124ANALYSIS OF EXPRESSED SEQUENCE TAGS (ESTS) FROM THE POLAR DIATOM FRAGILARIOPSIS CYLINDRUS1
Q41357503ATP binding and hydrolysis disrupt the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate-binding protein
Q30620912Accurate prediction of protein functional class from sequence in the Mycobacterium tuberculosis and Escherichia coli genomes using data mining
Q38988494Advances in genetic hearing loss: CIB2 gene
Q47627554An ATP-binding cassette transporter GhWBC1 from elongating cotton fibers
Q28131838An efficient algorithm for large-scale detection of protein families
Q48010202An evolutionary conserved group of plant GSK-3/shaggy-like protein kinase genes preferentially expressed in developing pollen
Q30783170Analytical methods for detecting paralogy in molecular datasets
Q40426108Analytical methods for studying the evolution of paralogs using duplicate gene datasets
Q42025644Assessing performance of orthology detection strategies applied to eukaryotic genomes
Q28145970Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel
Q37928933Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
Q28546970Biochemical Characterization of a Mycobacteriophage Derived DnaB Ortholog Reveals New Insight into the Evolutionary Origin of DnaB Helicases
Q41154069Calcium-Dependent Regulation of Ion Channels
Q30976853Changing T cell specificity by retroviral T cell receptor display
Q30955885Characterization and prediction of linker sequences of multi-domain proteins by a neural network.
Q51641430Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis.
Q52168509Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function.
Q24623075Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells
Q40101240Comparative Analysis of the Flavobacterium columnare Genomovar I and II Genomes
Q37563789Comparative analysis of complete genomes reveals gene loss, acquisition and acceleration of evolutionary rates in Metazoa, suggests a prevalence of evolution via gene acquisition and indicates that the evolutionary rates in animals tend to be conser
Q34670114Comparison of the complete protein sets of worm and yeast: orthology and divergence
Q46412317Copy Number Variation and Expression Analysis Reveals a Nonorthologous Pinta Gene Family Member Involved in Butterfly Vision.
Q42616468DEC: a new miniature inverted-repeat transposable element from the genome of the beetle Tenebrio molitor
Q36120284DNA microarrays--techniques and applications in microbial systems.
Q28276670Detection of internal repeats: how common are they?
Q62733678Detection of parallel functional modules by comparative analysis of genome sequences
Q47874875Differential requirements for basic amino acids in transcription factor IIIA-5S gene interaction
Q42654611Dipeptide frequency/bias analysis identifies conserved sites of nonrandomness shared by cysteine-rich motifs
Q30649929Directed evolution of ampicillin-resistant activity from a functionally unrelated DNA fragment: A laboratory model of molecular evolution
Q36089937Directed evolution of an aspartate aminotransferase with new substrate specificities
Q30175241Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold
Q42688912Downy mildew (Pl ( 8 ) and Pl ( 14 )) and rust (R ( Adv )) resistance genes reside in close proximity to tandemly duplicated clusters of non-TIR-like NBS-LRR-encoding genes on sunflower chromosomes 1 and 13.
Q30382268Duplication of the class I cytosolic small heat shock protein gene and potential functional divergence revealed by sequence variations flanking the {alpha}-crystallin domain in the genus Rhododendron (Ericaceae).
Q47730493Eukaryote genome duplication - where's the evidence?
Q44799827Evaluation of monocot and eudicot divergence using the sugarcane transcriptome.
Q64077647Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function
Q30873629Evolution of domain families
Q37890999Evolution of eukaryotic genome architecture: Insights from the study of a rapidly evolving metazoan, Oikopleura dioica: Non-adaptive forces such as elevated mutation rates may influence the evolution of genome architecture
Q34308577Evolutionary analysis by whole-genome comparisons
Q26991754Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease
Q39753576Exploration of novel motifs derived from mouse cDNA sequences
Q33695985Expression analysis of sugarcane shaggy-like kinase (SuSK) gene identified through cDNA subtractive hybridization in sugarcane (Saccharum officinarum L.)
Q30841456Expression and regulatory function of the transcription factor Sp1 in the uterine endometrium at early pregnancy: implications for epithelial phenotype
Q77895878Expression profiling using cDNA microarrays
Q48305528Fitness effects of mutation: testing genetic redundancy in Arabidopsis thaliana.
Q24649588Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family
Q27936590Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6.
Q41703462Functional genomics: going forwards from the databases
Q36281800Functional prediction: identification of protein orthologs and paralogs
Q40738340Future treatment modalities for meningiomas: targeting of neurofibromatosis type 2 and Ras-regulated pathways.
Q24802795Gene family evolution: an in-depth theoretical and simulation analysis of non-linear birth-death-innovation models
Q44733119Gene trapping with firefly luciferase in Arabidopsis. Tagging of stress-responsive genes
Q28139459Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT
Q39311679Genes coding for tryptophan-rich proteins are transcribed throughout the asexual cycle of Plasmodium falciparum
Q41728772Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins
Q34082670Genome annotation: from sequence to biology
Q30323005Genome archeology leading to the characterization and classification of transport proteins.
Q35802569Genome-wide identification and expression characterization of ABCC-MRP transporters in hexaploid wheat
Q24685762Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene
Q33178667Genomics, mutations and the Internet: the naming and use of parts
Q30330015Global perspectives on proteins: comparing genomes in terms of folds, pathways and beyond.
Q34669937Glycyrrhiza uralensis transcriptome landscape and study of phytochemicals
Q38449628Guidelines and recommendations for content, structure, and deployment of mutation databases
Q33828937Heterochromatin function in complex genomes
Q54186019Homology evolving
Q49487988Hypermethylated LTR retrotransposon exhibits enhancer activity.
Q25255795INVHOGEN: a database of homologous invertebrate genes
Q41032296Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor
Q24670352Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning
Q35586786Identifying single copy orthologs in Metazoa
Q39146448Inferring Function from Homology
Q36076300Influence of ATP-Binding Cassette Transporters in Root Exudation of Phytoalexins, Signals, and in Disease Resistance
Q34487052Insights into protein function through large-scale computational analysis of sequence and structure
Q21144465Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif
Q33703747Ionizing radiation and genetic risks. X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics
Q24318619Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family
Q24544306Isovariant dynamics expand and buffer the responses of complex systems: the diverse plant actin gene family
Q34600459L-tartaric acid synthesis from vitamin C in higher plants
Q38551341Large-scale taxonomic profiling of eukaryotic model organisms: a comparison of orthologous proteins encoded by the human, fly, nematode, and yeast genomes.
Q47970508Leucine-rich repeat glycoproteins of the extracellular matrix
Q34768058Linking the potato genome to the conserved ortholog set (COS) markers
Q33635991Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function
Q24633106Long-range function of an intergenic retrotransposon
Q28655231Mammalian keratin associated proteins (KRTAPs) subgenomes: disentangling hair diversity and adaptation to terrestrial and aquatic environments
Q43620565Mercuric ion inhibition of eukaryotic transcription factor binding to DNA.
Q33538561Microbial genome sequencing and pathogenesis
Q52567374Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe.
Q34150461Modular enzymes
Q77754837Modularity of serpins. A bifunctional chimera possessing alpha1-proteinase inhibitor and thyroxine-binding globulin properties
Q33904193Molecular biology and genetics of the Rh blood group system
Q57252772Molecular evolution of immunoglobulin and fibronectin domains in titin and related muscle proteins
Q50025945Multi-omics driven assembly and annotation of the sandalwood (Santalum album) genome
Q34280166Multiple alignment of complete sequences (MACS) in the post-genomic era.
Q34611101Mutator-like elements in Arabidopsis thaliana. Structure, diversity and evolution
Q30350384NMR structure determination of proteins supplemented by quantum chemical calculations: detailed structure of the Ca2+ sites in the EGF34 fragment of protein S.
Q36519396New enzymes from environmental cassette arrays: functional attributes of a phosphotransferase and an RNA-methyltransferase
Q30359111Occurrence of protein structure elements in conserved sequence regions.
Q47861102Organization and structural evolution of four multigene families in Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.
Q27860860OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Q35810257OrthoVenn: a web server for genome wide comparison and annotation of orthologous clusters across multiple species
Q46769503PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.
Q30432219Patterns of protein-fold usage in eight microbial genomes: a comprehensive structural census
Q34192362Perspective: transposable elements, parasitic DNA, and genome evolution
Q45779524Phylogenetic relationships of B-related phytochromes in the Brassicaceae: Redundancy and the persistence of phytochrome D.
Q28266110Phylogenomics: improving functional predictions for uncharacterized genes by evolutionary analysis
Q56136135Plant ABC Transporters
Q37619474Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites
Q36144782Postnatal development- and age-related changes in DNA-methylation patterns in the human genome
Q33848770Potassium transport in fungi and plants
Q41736499Predicting functions from protein sequences--where are the bottlenecks?
Q35156329Prediction and analysis of canonical EF hand loop and qualitative estimation of Ca²⁺ binding affinity
Q62492954Prediction of functional class of novel viral proteins by a statistical learning method irrespective of sequence similarity
Q39940236Prediction of interactiveness of proteins and nucleic acids based on feature selections
Q34497721Protein multifunctionality: principles and mechanisms.
Q36157888RStrucFam: a web server to associate structure and cognate RNA for RNA-binding proteins from sequence information
Q35874459Rapid cloning and bioinformatic analysis of spinach Y chromosome-specific EST sequences
Q35109280Reciprocal domain evolution within a transactivator in a restricted sequence space
Q35208363SVM-Prot: Web-based support vector machine software for functional classification of a protein from its primary sequence
Q27936833Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters
Q32054225Specific RNA binding proteins constructed from zinc fingers
Q35855730Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate
Q30489524Streamlining and large ancestral genomes in Archaea inferred with a phylogenetic birth-and-death model
Q34482580Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements
Q38296026Structure and function of the Escherichia coli RecE protein, a member of the RecB nuclease domain family
Q24533519Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
Q46546607Structure-critical distribution of aromatic residues in the fibronectin type III protein family
Q24647366The ADF homology (ADF-H) domain: a highly exploited actin-binding module
Q43603113The Arabidopsis thaliana ABC protein superfamily, a complete inventory
Q28362216The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement
Q27936664The COG database: a tool for genome-scale analysis of protein functions and evolution
Q21284294The COG database: an updated version includes eukaryotes
Q24645290The EF-hand domain: a globally cooperative structural unit
Q39808750The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function
Q47682284The alpha-mannosidases: phylogeny and adaptive diversification
Q30159978The evolutionary relationship of the domain architectures in the RhoGEF-containing proteins
Q50129307The glucose transporter of Escherichia coli with circularly permuted domains is active in vivo and in vitro
Q40384280The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2.
Q33316861The origin of a novel gene through overprinting in Escherichia coli
Q28765097The origin of alternation of generations in land plants: a focus on matrotrophy and hexose transport
Q29618530The probability of duplicate gene preservation by subfunctionalization
Q24812477The rarity of gene shuffling in conserved genes
Q24800474The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana
Q39748043The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and hematopoietic cells
Q27646746The solution structure of the Mg2+form of soybean calmodulin isoform 4 reveals unique features of plant calmodulins in resting cells
Q31118789The structure of the protein universe and genome evolution
Q34914285Three multigene families in Plasmodium parasites: facts and questions
Q33890168Transposable elements and host genome evolution
Q25256560TreeFam: a curated database of phylogenetic trees of animal gene families
Q47969748Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis
Q37045527Understanding the molecular machinery of genetics through 3D structures
Q47279248When size is important. Accommodation of magnesium in a calcium binding regulatory domain.
Q30874386Who's your neighbor? New computational approaches for functional genomics
Q34974127YOGY: a web-based, integrated database to retrieve protein orthologs and associated Gene Ontology terms
Q48369421ZNF232: structure and expression analysis of a novel human C(2)H(2) zinc finger gene, member of the SCAN/LeR domain subfamily

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