Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

scientific article

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0092-8674(00)80985-X
P3181OpenCitations bibliographic resource ID615389
P698PubMed publication ID8565076

P50authorThomas JessellQ2425113
P2093author name stringT Edlund
C L Stewart
M Mendelsohn
S L Pfaff
P2860cites workRequirement for Lim1 in head-organizer functionQ24312737
Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survivalQ24595086
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectodermQ28288932
Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissuesQ28294656
Compartments and appendage development in DrosophilaQ28301002
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domainQ28564170
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochordQ28566360
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysisQ34309695
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.Q34310844
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegansQ34560342
Cell cycle dependence of laminar determination in developing neocortexQ34955579
Neurogenesis in spinal cord of mouse: an autoradiographic analysisQ42442860
Regulation of tyrosine hydroxylase-containing amacrine cell number in larval frog retinaQ44197355
Lineage, arrangement, and death of clonally related motoneurons in chick spinal cordQ44378422
Formation and migration of neuroblasts in the spinal cord of the chick embryoQ44410157
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene DeltaQ46026585
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.Q47069339
Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafishQ48070371
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genesQ48077000
Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.Q52249431
Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tubeQ63488075
Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochordQ68189634
Cell-specific regulation of neuronal production in the larval frog retinaQ68831243
New dopaminergic and indoleamine-accumulating cells in the growth zone of goldfish retinas after neurotoxic destructionQ70357863
Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plateQ70732933
Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiationQ71725603
The mitotic patterns in the spinal cord of the chick embryo and their relation to histogenetic processesQ79576962
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectISL1 transcription factor, LIM/homeodomainQ21986053
P304page(s)309-20
P577publication date1996-01-26
P1433published inCellQ655814
P1476titleRequirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
P478volume84

Reverse relations

cites work (P2860)
Q580239351H, 13C and 15N assignment of the Isl-1 homeodomain
Q47993870A LIM-homeodomain combinatorial code for motor-neuron pathway selection
Q27678554A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions
Q78245424A case of mistaken identity
Q24644187A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
Q29616555A distal enhancer and an ultraconserved exon are derived from a novel retroposon
Q35744025A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene
Q83229176A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
Q54147004A genotype-phenotype correlation study reveals that a non-coding RNA might be associated with cardiovascular anomalies in fetuses with WHS.
Q28505629A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity
Q41853998A regulatory network to segregate the identity of neuronal subtypes
Q27330110A strategy to discover new organizers identifies a putative heart organizer
Q41689783Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9.
Q64100664Adult Expression Outlines Ventralized Derivatives Along Zebrafish Neuraxis
Q37877223Adult neurogenesis and brain regeneration in zebrafish
Q48647912Adult stem cells in the knifefish cerebellum.
Q82139161An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
Q28138625Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9
Q28298056Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Q41680647Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus
Q52630006Beadex, a Drosophila LIM domain only protein, function in follicle cells is essential for egg development and fertility.
Q28590588Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
Q42710100Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons
Q40915621CEPU-1, an immunoglobulin superfamily molecule, has cell adhesion activity and shows dynamic expression patterns in chick embryonic spinal cord
Q28506542CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy
Q22011105CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis
Q37689127Caudal dysgenesis in islet‐1 transgenic mice
Q33896623Cell death of spinal interneurones
Q37378410Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development
Q40657251Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine tumor cell line
Q48291182Cellular activation in neuroregeneration
Q41549759Cellular and molecular biology of neural crest cell lineage determination
Q88956333Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells
Q42853712Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis
Q27314901Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development
Q36736868Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction
Q40962233Characterization of the porcine Lhx3/LIM-3/P-Lim LIM homeodomain transcription factor
Q30488004Chick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neurons
Q42266020Chicken HOXA3 gene: its expression pattern and role in branchial nerve precursor cell migration
Q41690638Chip and apterous physically interact to form a functional complex during Drosophila development.
Q35140077Cholestenoic acids regulate motor neuron survival via liver X receptors
Q34264240Chondrolectin mediates growth cone interactions of motor axons with an intermediate target
Q40521787Cloning and analysis of axolotl ISL2 and LHX2 LIM-homeodomain transcription factors
Q28505105Cloning and expression analysis of the mouse T-box gene tbx20
Q24313014Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein
Q28594759Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
Q30413027Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons
Q35156785Concocting cholinergy
Q50764721Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein.
Q24652425Conservation of the expression and function of apterous orthologs in Drosophila and mammals
Q48038312Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
Q52166013Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb.
Q24797230Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Q36070041Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex
Q83230869Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification
Q36448244Crystallization and diffraction of an Isl1-Ldb1 complex
Q28291924Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Q37213821Cytochrome p450 cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells
Q35540377DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
Q41721616DeLIMiting development
Q35157345Decoding the LIM development code.
Q28512489Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a
Q28143035Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice
Q50352545Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice.
Q36672276Development and differentiation of neural rosettes derived from human embryonic stem cells
Q43574474Developmental restriction of the LIM homeodomain transcription factor Islet-1 expression to cholinergic neurons in the rat striatum
Q39009603Developmental specification of forebrain cholinergic neurons
Q48621205Differences in neuronal differentiation between the transient cranial (Frorieps') and normal dorsal root ganglia.
Q41678578Differentiation of the vertebrate neural tube.
Q63364317Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity
Q29616200Directed differentiation of embryonic stem cells into motor neurons
Q28144856Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis
Q28658047Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway
Q44473486Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
Q45713973Dorsalization of the neural tube by Xenopus tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm
Q41066232Dorsoventral patterning and oligodendroglial specification in the developing central nervous system
Q37474815Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity
Q51829029Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H).
Q52100384Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia.
Q30359827Dynamic expression of transcription factor Brn3b during mouse cranial nerve development
Q48373249Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex.
Q52126466Early development of the mesencephalic trigeminal nucleus.
Q81339042Early specification of ascidian larval motor neurons
Q64068391Effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryonic development
Q50753363Elucidation of target muscle and detailed development of dorsal motor neurons in chick embryo spinal cord.
Q37805824Embryonic and embryonic-like stem cells in heart muscle engineering
Q84963191Enforced expression of the transcription factor HOXD3 under the control of the Wnt1 regulatory element modulates cell adhesion properties in the developing mouse neural tube
Q35566875Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms
Q38959723Epispadias and the associated embryopathies: genetic and developmental basis.
Q47146719Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells
Q34170575Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression.
Q36281485Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8.
Q35840689Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice
Q48494708Expression analysis of Sulf1 in the chick forebrain at early and late stages of development.
Q34731270Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract
Q48052855Expression and regulation of a netrin homologue in the zebrafish embryo.
Q34050251Expression of Isl1 during mouse development
Q34154079Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear
Q44124555Expression of Vema in the developing mouse spinal cord and optic chiasm
Q51843015Expression of delta-protocadherins in the spinal cord of the chicken embryo.
Q34222124Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo
Q33889628Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors.
Q34178570Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina
Q59484986Expression ofSox3 throughout the developing central nervous system is dependent on the combined action of discrete, evolutionarily conserved regulatory elements
Q52192596Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons.
Q48042170Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
Q34345665Fasciculation and guidance of spinal motor axons in the absence of FGFR2 signaling
Q28591344Fate of midbrain dopaminergic neurons controlled by the engrailed genes
Q30576356Fine tuning of craniofacial morphology by distant-acting enhancers
Q36084793Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways
Q35184826From cells to circuits: development of the zebrafish spinal cord
Q27028183From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate
Q27021904From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity
Q37749840From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases.
Q27310250Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution
Q24644579Functional analysis of the nuclear LIM domain interactor NLI
Q50255242Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.
Q38300149Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish
Q33826742Functions of LIM-homeobox genes.
Q40872043GFRalpha 1 is required for development of distinct subpopulations of motoneuron.
Q38601061Gaskell revisited: new insights into spinal autonomics necessitate a revised motor neuron nomenclature.
Q49347958Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.
Q38748843Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
Q40861559Gene disruption in mice: models of development and disease
Q35029666Gene expression cascades in pancreatic development
Q40465125Gene expression profile following stable expression of the cellular prion protein.
Q27301944Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis
Q36657568Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2.
Q34286940Gene regulatory factors in pancreatic development
Q35498674Gene regulatory networks in embryonic stem cells and brain development
Q26773019Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells
Q38114332Generating spinal motor neuron diversity: a long quest for neuronal identity
Q37294304Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues
Q40859949Genetic and epigenetic mechanisms contribute to motor neuron pathfinding
Q77892143Genetic and molecular analyses of motoneuron development
Q38601651Genetically identified spinal interneurons integrating tactile afferents for motor control
Q35170776Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy
Q33316034Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes
Q45871734Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis
Q28609086Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
Q46613385Growing and working with spinal motor neurons
Q44519117Growth factors induce neurogenesis in the ciliary body
Q37660584Gut endocrine cell development
Q92732166HIF-1α is required for development of the sympathetic nervous system
Q30441639Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss
Q28504794Hes1 is expressed in the second heart field and is required for outflow tract development
Q89823743Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression
Q39016217High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1.
Q33366495How to build transcriptional network models of mammalian pattern formation
Q33850885How to construct a neural tube
Q37570826Hox networks and the origins of motor neuron diversity
Q35617882Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry
Q51416081Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development.
Q37776428Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells
Q36781097ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex
Q36107279ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism
Q28590005ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
Q36092734ISL1 common variant rs1017 is not associated with susceptibility to congenital heart disease in a Chinese population
Q30470799ISL1 directly regulates FGF10 transcription during human cardiac outflow formation
Q52678079ISL1 is upregulated in breast cancer and promotes cell proliferation, invasion, and angiogenesis.
Q50338644ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model.
Q64231142ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7
Q37397243ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.
Q39030617ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.
Q43517959Identification and biological characterization of chicken embryonic cardiac progenitor cells
Q24682789Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
Q33904313Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines
Q24309294Identification of a polymorphic, neuron-specific chromatin remodeling complex
Q33481774Identification of regulatory elements in the Isl1 gene locus
Q48413469Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.
Q40946703Immortalized human dorsal root ganglion cells differentiate into neurons with nociceptive properties
Q47584986Immunohistochemical detection of islet-1 and neuronal nitric oxide synthase in the dorsal root ganglia (DRG) of sheep fetuses during gestation
Q27650961Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
Q39012502In vitro generation of motor neuron precursors from mouse embryonic stem cells using mesoporous nanoparticles.
Q28301584Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
Q28511893Interactions between LIM domains and the LIM domain-binding protein Ldb1
Q28593772Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins
Q46415511Intron-specific patterns of divergence of lin-11 regulatory function in the C. elegans nervous system
Q46218853Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor
Q28538206Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes
Q28190508Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
Q42169259Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm.
Q35432551Isl1 is required for multiple aspects of motor neuron development
Q28504915Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis
Q46520695Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10, and Wnt5a.
Q43243916Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
Q35485151Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood
Q34429262Islet-1 Is essential for pancreatic β-cell function
Q30497245Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells
Q48701577Islet-1 expression and its colocalization with luteinising hormone, thyroid-stimulating hormone and oestrogen receptor alpha in the developing pituitary gland of the sheep foetus.
Q52088399Islet-1 expression in the developing chicken inner ear.
Q54425771Islet-1 immunoreactivity in the developing retina of Xenopus laevis.
Q37317406Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.
Q40747425Islet-1 marks the early heart rudiments and is asymmetrically expressed during early rotation of the foregut in the chick embryo
Q34869281Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development
Q42817394Islet-1: a potentially important role for an islet cell gene in visceral fat.
Q28508769Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
Q35155193Islet1 and its co-factor Ldb1 are expressed in quiescent cells of mouse intestinal epithelium
Q37078408Islet1 deletion causes kidney agenesis and hydroureter resembling CAKUT.
Q51800787Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.
Q38339086Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons
Q35224570Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice
Q36779166Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8
Q41852733LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function
Q74548348LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions
Q46053727LIM family transcription factors regulate the subtype-specific morphogenesis of retinal horizontal cells at post-migratory stages
Q41130545LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system
Q28591209LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
Q48431281LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry.
Q33614957LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3
Q36196340LIM-homeodomain genes in mammalian development and human disease.
Q33535172LIMitless combinations?
Q34386792Lhx2 regulates a cortex-specific mechanism for barrel formation
Q34341831Lhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons
Q35441732Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.
Q36051480Lhx6 and Lhx8: cell fate regulators and beyond
Q35768795Lim homeobox genes in the Ctenophore Mnemiopsis leidyi: the evolution of neural cell type specification
Q33745329Lineages and transcription factors in the specification of vertebrate primary sensory neurons
Q88736822Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury
Q30479042Maintenance of motor neuron progenitors in Xenopus requires a novel localized cyclin.
Q38972220Making sense out of spinal cord somatosensory development
Q62735788Mammalian Motoneuron Axon Targeting Requires Receptor Protein Tyrosine Phosphatases and
Q34312928Mechanisms and molecules in motor neuron specification and axon pathfinding
Q79744649Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons
Q36395878MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation
Q44848925MicroRNA-31 suppresses the self-renewal capability of α2δ1+ liver tumor-initiating cells by targeting ISL1.
Q35441996MicroRNA-383 regulates the apoptosis of tumor cells through targeting Gadd45g
Q33791987MicroRNA-mediated control of oligodendrocyte differentiation
Q28082501Molecular and cellular development of spinal cord locomotor circuitry
Q34017922Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.
Q33737440Molecular mechanisms regulating motor neuron development and degeneration.
Q52183496Molecular regulators involved in vertebrate eye development.
Q47640113Molecular specification of facial branchial motor neurons in vertebrates
Q40899598Motoneuron differentiation of immortalized human spinal cord cell lines
Q41655724Motoneuron differentiation, survival and synaptogenesis
Q41329976Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse
Q35841010Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling
Q52178612Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.
Q73634966Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS
Q28587718Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
Q48496593Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development.
Q24540185Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene
Q43705301Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion
Q33414415Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression
Q34114837Neural patterning in the vertebrate embryo
Q36269174Neural tube expression of pituitary adenylate cyclase-activating peptide (PACAP) and receptor: potential role in patterning and neurogenesis
Q41600989Neural tube morphogenesis.
Q48156753Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system
Q52188024Neuronal cell death.
Q41755509Neuronal diversification: development of motor neuron subtypes
Q24595870Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
Q29616039Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Q52176763Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons.
Q28584790Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia
Q34473957Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain
Q28512715Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain
Q45259776Noggin and basic FGF were implicated in forebrain fate and caudal fate, respectively, of the neural tube-like structures emerging in mouse ES cell culture
Q24602347Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
Q43123070Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities
Q28589794Notch1 control of oligodendrocyte differentiation in the spinal cord
Q24604432Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development
Q97640439OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR
Q48777753Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the islet-3 LIM/homeodomain protein.
Q38323216Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification
Q80514451Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation
Q41753651Origin and molecular specification of striatal interneurons.
Q34605372Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the Dlmo gene
Q28205608PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development
Q30493548PHOX2A regulation of oculomotor complex nucleogenesis
Q85225446POU homeodomain protein OCT1 modulates islet 1 expression during cardiac differentiation of P19CL6 cells
Q21203078POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
Q47932670Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
Q38531169Pancreatic islet cell development and regeneration
Q38543237Pancreatic regeneration: basic research and gene regulation
Q41110651Patterning cascades in the neural tube. Neural development.
Q33659785Patterning motoneurons in the vertebrate nervous system
Q33855370Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas
Q30362535Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation.
Q28571762Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
Q54226937Pea3 determines the isthmus region at the downstream of Fgf8-Ras-ERK signaling pathway.
Q89128831Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features
Q35214691Prediction of active nodes in the transcriptional network of neural tube patterning
Q28594835Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
Q36913455Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling
Q48037293Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system
Q96135898PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells
Q35285752Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.
Q24309381Receptor tyrosine phosphatase PTPγ is a regulator of spinal cord neurogenesis
Q27687840Regenerating functional heart tissue for myocardial repair
Q36882039Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene
Q41991222Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
Q28577921Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration
Q28511868Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
Q28505161Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
Q37689535Restricted expression of classic cadherins in the spinal cord of the chicken embryo
Q41325229Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord
Q44863933Retinoic acid and the control of dorsoventral patterning in the avian spinal cord
Q44607280Retinoid Receptor Signaling in Postmitotic Motor Neurons Regulates Rostrocaudal Positional Identity and Axonal Projection Pattern
Q44309231Role of EphA4 in defining the position of a motoneuron pool within the spinal cord
Q37470219Role of endogenous insulin gene enhancer protein ISL-1 in angiogenesis
Q36923803Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals
Q37010496STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
Q34582129Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.
Q38231221Segregation of neuronal and neuroendocrine differentiation in the sympathoadrenal lineage
Q34771774Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord
Q33264123Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death
Q27312464Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium
Q34154050Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
Q30657194Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves
Q33796353Signaling mechanisms in pituitary morphogenesis and cell fate determination
Q40796007Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain
Q28483805Sirenomelia phenotype in bmp7;shh compound mutants: a novel experimental model for studies of caudal body malformations
Q35655538Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube
Q74624736Sonic hedgehog promotes neuronal differentiation of murine spinal cord precursors and collaborates with neurotrophin 3 to induce Islet-1
Q73507898Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro
Q73555176Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
Q64237452Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin
Q50710443Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development.
Q31997246Specification of motor neuron identity by the MNR2 homeodomain protein
Q47136847Specification of murine ground state pluripotent stem cells to regional neuronal populations.
Q34141441Specification of neuronal fates in the ventral neural tube
Q46927254Specifying motor neurons and their connections
Q34127852Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability
Q28083463Spinal primitives and intra-spinal micro-stimulation (ISMS) based prostheses: a neurobiological perspective on the "known unknowns" in ISMS and future prospects
Q27675210Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification
Q30360691Synaptic control of motoneuronal excitability.
Q52104347Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors.
Q37288224Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity.
Q48051727TWH regulates the development of subsets of spinal cord neurons
Q89259652Talking back: Development of the olivocochlear efferent system
Q33853566Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity
Q92707753Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse
Q40649340The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development
Q38481180The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis
Q47072467The Drosophila LIM-homeo domain protein Islet antagonizes pro-neural cell specification in the peripheral nervous system
Q43123064The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis
Q46852606The Drosophila islet gene governs axon pathfinding and neurotransmitter identity
Q33573729The Isl1-Lhx3 Complex Promotes Motor Neuron Specification by Activating Transcriptional Pathways that Enhance Its Own Expression and Formation
Q28137861The LIM domain: regulation by association
Q37240685The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse
Q47069046The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans
Q45819556The LIM homeobox gene ceh-14 is required for phasmid function and neurite outgrowth
Q52573819The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila.
Q38315781The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells
Q24311675The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
Q28504624The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
Q35171430The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
Q42321282The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression.
Q50320053The LIM-homeodomain transcription factor Islet2a promotes angioblast migration.
Q34184539The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.
Q28505904The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities
Q24290430The LIM/homeodomain protein islet-1 modulates estrogen receptor functions
Q52105928The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.
Q38297804The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development
Q46381166The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.
Q46021705The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.
Q48546876The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.
Q22010266The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23
Q71786343The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
Q28144732The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix
Q28588344The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Q77773409The homeodomain transcription factors Islet 1 and HB9 are expressed in adult alpha and gamma motoneurons identified by selective retrograde tracing
Q33941010The lineage contribution and role of Gbx2 in spinal cord development
Q42742817The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
Q24329116The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors
Q48321798The postnatal human filum terminale is a source of autologous multipotent neurospheres capable of generating motor neurons
Q92621275The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion
Q46196456The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field
Q27021998The role of homeobox genes in retinal development and disease
Q28586506The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling
Q28589973Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
Q45223130Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells
Q92059092Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury
Q48300515Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions
Q41170335Transcription factor genes and the developing eye: a genetic perspective
Q34985769Transcription factors and effectors that regulate neuronal morphology
Q34460402Transcription factors in pituitary development
Q37006585Transcriptional and epigenetic dynamics during specification of human embryonic stem cells
Q34988217Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1.
Q33540096Transcriptional control of neurotransmitter phenotype
Q36727615Transcriptional pathways in second heart field development
Q41074680Transcriptional regulation of axon pathfinding
Q38126794Transcriptional regulation of guidance at the midline and in motor circuits
Q36799115Transcriptional regulation of vertebrate axon guidance and synapse formation
Q36354585Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification
Q24646171Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity
Q34142599Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells
Q39403082Transgenic enrichment of mouse embryonic stem cell-derived progenitor motor neurons
Q37478036Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice
Q44451984Transmembrane sema4E guides branchiomotor axons to their targets in zebrafish.
Q57572074Trio Controls the Mature Organization of Neuronal Clusters in the Hindbrain
Q30497143Turning heads: development of vertebrate branchiomotor neurons
Q34408125Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
Q90683980Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS
Q34185937Vertebrate neural cell-fate determination: lessons from the retina
Q51996534Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.
Q34238198Wnt signaling in caudal dysgenesis and diabetic embryopathy
Q48049343Xenopus LIM motif-containing protein kinase, Xlimk1, is expressed in the developing head structure of the embryo
Q47346965Xenopus Xlmo4 is a GATA cofactor during ventral mesoderm formation and regulates Ldb1 availability at the dorsal mesoderm and the neural plate
Q37024214Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α.
Q34114038cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4.
Q52568445even-skipped determines the dorsal growth of motor axons in Drosophila.
Q47073921floating head and masterblind regulate neuronal patterning in the roof of the forebrain
Q26744461miRNAs As Emerging Regulators of Oligodendrocyte Development and Differentiation
Q41827449prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons

Search more.