Flux coupling in a neuronal glutamate transporter

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Flux coupling in a neuronal glutamate transporter is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1053552941
P356DOI10.1038/383634A0
P3181OpenCitations bibliographic resource ID1136665
P698PubMed publication ID8857541
P5875ResearchGate publication ID14346995

P2093author name stringM P Kavanaugh
N Zerangue
P2860cites workFunctional comparisons of three glutamate transporter subtypes cloned from human motor cortexQ24306108
An excitatory amino-acid transporter with properties of a ligand-gated chloride channelQ24323343
Interaction of L-cysteine with a human excitatory amino acid transporterQ24530151
Localization of neuronal and glial glutamate transportersQ28238076
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamateQ29620128
Noise analysis of the glutamate-activated current in photoreceptorsQ34017144
Primary structure and functional characterization of a high-affinity glutamate transporterQ34205379
Direct measurement of intracellular pH changes in Xenopus eggs at fertilization and cleavageQ36205541
Retinal glial cell glutamate transporter is coupled to an anionic conductanceQ37631116
Effect of anoxia on ion distribution in the brainQ39813351
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanismsQ40396457
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamateQ41278939
Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cellsQ46207287
Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytesQ48135996
Active transport of L-glutamate by membrane vesicles isolated from rat brainQ48159648
The glial cell glutamate uptake carrier countertransports pH-changing anionsQ48396387
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisQ48609930
Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake.Q48857498
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors.Q48944206
Ion fluxes associated with excitatory amino acid transport.Q49042016
Modulation of non-vesicular glutamate release by pHQ59040419
Electrogenic glutamate uptake in glial cells is activated by intracellular potassiumQ59062509
Glutamate receptor desensitization and its role in synaptic transmissionQ69378713
Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistryQ71712447
Reductions of ?-Aminobutyric Acid and Glutamate Uptake and (Na++ K+)-ATPase Activity in Brain Slices and Synaptosomes by Arachidonic AcidQ72543900
Hydrogen ion cotransport by the renal brush border glutamate transporterQ72568601
Differential modulation of human glutamate transporter subtypes by arachidonic acidQ72645544
P433issue6601
P407language of work or nameEnglishQ1860
P921main subjectchloride transmembrane transportQ15333422
Solute carrier family 1 member 1Q21114341
P304page(s)634-7
P577publication date1996-10-17
P1433published inNatureQ180445
P1476titleFlux coupling in a neuronal glutamate transporter
P478volume383

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cites work (P2860)
Q43809086(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes
Q802252925-Hydroxytryptamine-mediated increase in glutamate uptake by the leech giant glial cell
Q34179022A Monte Carlo model reveals independent signaling at central glutamatergic synapses
Q36281611A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State
Q33367112A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis
Q36054043A channel in a transporter.
Q27653127A competitive inhibitor traps LeuT in an open-to-out conformation
Q52691301A computational study of astrocytic glutamate influence on post-synaptic neuronal excitability.
Q35842139A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters
Q33967358A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter
Q37638989A general method for determining secondary active transporter substrate stoichiometry.
Q43996674A hydrophobic domain in glutamate transporters forms an extracellular helix associated with the permeation pathway for substrates
Q35294199A novel optical intracellular imaging approach for potassium dynamics in astrocytes
Q48630108A postsynaptic excitatory amino acid transporter with chloride conductance functionally regulated by neuronal activity in cerebellar Purkinje cells.
Q28273121A trimeric quaternary structure is conserved in bacterial and human glutamate transporters
Q57612071Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling
Q48527062Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes.
Q26783129Activity-Dependent Plasticity of Astroglial Potassium and Glutamate Clearance
Q47956606Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms.
Q37256701Advancement of therapies for neuroprotection in multiple sclerosis
Q90047711Allosteric gate modulation confers K+ coupling in glutamate transporters
Q37616474Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia
Q90482483Amino Acid Transport Across the Mammalian Intestine
Q43668409Amino acid transporter CAATCH1 is also an amino acid-gated cation channel
Q35184476Amino acid transporters: roles in amino acid sensing and signalling in animal cells
Q46216841Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity
Q28141147Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
Q47680317Analysis of the quality of crystallographic data and the limitations of structural models
Q48396002Anion currents and predicted glutamate flux through a neuronal glutamate transporter.
Q47892226Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4.
Q48921191Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4.
Q42448608Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals
Q44640396Arginine 445 Controls the Coupling between Glutamate and Cations in the Neuronal Transporter EAAC-1
Q36296014Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter
Q38632942Astrocyte sodium signaling and the regulation of neurotransmission.
Q64245699Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release
Q52659360Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke.
Q37794386Astrocytes in Alzheimer's disease
Q48350374Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity.
Q43268756Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity.
Q47553945Astroglial Glutamate Signaling and Uptake in the Hippocampus.
Q38788230Astroglial glutamate transporters coordinate excitatory signaling and brain energetics.
Q39115057Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission
Q64058308Binding and transport of D-aspartate by the glutamate transporter homolog Glt
Q27677232Binding thermodynamics of a glutamate transporter homolog
Q40753199Biochemical characterization of the C4-dicarboxylate transporter DctA from Bacillus subtilis
Q47809134Bioenergetics of neurotransmitter transport
Q48377837Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology
Q90348823Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity
Q43765170Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca(2+) and Na(+) in cultured cerebellar neurons
Q42514065Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons
Q52536662C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells.
Q73209553CNS energy metabolism as related to function
Q38804730Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?
Q40937985Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation
Q41724740Cellular distribution and kinetic properties of high-affinity glutamate transporters
Q24654460Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration
Q35938786Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons
Q38155806Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease
Q51065999Characterisation of the DAACS Family Escherichia coli Glutamate/Aspartate-Proton Symporter GltP Using Computational, Chemical, Biochemical and Biophysical Methods.
Q44621403Characterization of a protein of the plastid inner envelope having homology to animal inorganic phosphate, chloride and organic-anion transporters
Q48329959Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.
Q36137442Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter
Q26770781Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?
Q33680880Clearance of glutamate inside the synapse and beyond
Q22003724Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)
Q40598001Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis.
Q35676834Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria
Q40687672Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters.
Q28140048Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange
Q36409591Computational Studies of Glutamate Transporters
Q36589222Conformational ensemble of the sodium-coupled aspartate transporter
Q62035571Conformational heterogeneity of the aspartate transporter GltPh
Q58595127Consensus designs and thermal stability determinants of a human glutamate transporter
Q34118376Conservation of amino acid transporters in fungi, plants and animals.
Q36006874Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter
Q35843861Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh
Q42486695Contribution of astrocytic glutamate and GABA uptake to corticostriatal information processing.
Q48233615Control of Glutamate Transport by Extracellular Potassium: Basis for a Negative Feedback on Synaptic Transmission
Q64063761Control of Long-Term Plasticity by Glutamate Transporters
Q36295999Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1
Q34600101Cotransporters as molecular water pumps
Q42368299Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
Q27683834Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
Q43691960Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions
Q27643578Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
Q99711524Critical Neurotransmitters in the Neuroimmune Network
Q57952962Cryo-EM structure of the human neutral amino acid transporter ASCT2
Q27685469Crystal structure of a substrate-free aspartate transporter
Q26996723Current approaches to enhance glutamate transporter function and expression
Q48657714Currents evoked in Bergmann glial cells by parallel fibre stimulation in rat cerebellar slices.
Q45749363Cysteine mutagenesis reveals alternate proximity between transmembrane domain 2 and hairpin loop 1 of the glutamate transporter EAAT1.
Q36526395Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positions
Q48034731Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue
Q34282413Cysteine transport through excitatory amino acid transporter 3 (EAAT3).
Q43982363Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1.
Q57199160Cytoskeletal Anchoring of GLAST Determines Susceptibility to Brain Damage
Q50067883Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Q28345050Depolarization-induced pH microdomains and their relationship to calcium transients in isolated snail neurones
Q37356670Deriving the time course of glutamate clearance with a deconvolution analysis of astrocytic transporter currents
Q35890758Dicarboxylate transport by rhizobia
Q39000404Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions.
Q35955897Differential expression of the glutamate transporter GLT-1 in pancreas
Q48569536Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1.
Q42175041Direct visualization of glutamate transporter elevator mechanism by high-speed AFM.
Q35637408Displacing hexokinase from mitochondrial voltage-dependent anion channel impairs GLT-1-mediated glutamate uptake but does not disrupt interactions between GLT-1 and mitochondrial proteins.
Q43869538Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1.
Q42878249Distribution of Na,K-ATPase α subunits in rat vestibular sensory epithelia.
Q33676261Disulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductance
Q35552926Dopamine transporter: Basic aspects and neuroimaging
Q28217171Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter
Q35215960Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore
Q36838857Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter
Q34268987EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake
Q36904469EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders
Q30990921Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1
Q43701698Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina.
Q48904948Effect of benzodiazepines on the epithelial and neuronal high-affinity glutamate transporter EAAC1.
Q35026658Effects of increased extracellular glutamate levels on the local field potential in the brain of anaesthetized rats
Q41931385Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil
Q36941134Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1
Q36100152Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling
Q44502773Electrophysiological evidence for glial-subtype glutamate transporter functional expression in rat cerebellar granule neurons.
Q48659347Elevated ammonium levels: differential acute effects on three glutamate transporter isoforms.
Q57810063Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier
Q34991061Energy utilization in the ischemic/reperfused brain
Q42083110Engineering the glutamate transporter homologue GltPh using protein semisynthesis
Q34068453Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.
Q36949537Evidence for change in current-flux coupling of GLT1 at high glutamate concentrations in rat primary forebrain neurons and GLT1a-expressing COS-7 cells
Q48372141Examination of glutamate transporter heterogeneity using synaptosomal preparations
Q24313586Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
Q37489935Excitatory amino acid transporters as potential drug targets.
Q38340430Excitatory amino acid transporters of the salamander retina: identification, localization, and function.
Q34784321Excitatory amino acid transporters: keeping up with glutamate.
Q27011208Excitatory amino acid transporters: roles in glutamatergic neurotransmission
Q26752408Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle
Q48536767Expression of glutamate uptake transporters after dibutyryl cyclic AMP differentiation and traumatic injury in cultured astrocytes.
Q42506952Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments
Q37163189Extracellular glutamate concentration in hippocampal slice
Q40255443Extracellular glutamate: functional compartments operate in different concentration ranges.
Q41566758Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications
Q49110202Fast removal of synaptic glutamate by postsynaptic transporters.
Q46487544Fluorescence techniques for studying cloned channels and transporters expressed in Xenopus oocytes
Q37095437Fluorometric measurements of conformational changes in glutamate transporters
Q35556342Free energy simulations of ligand binding to the aspartate transporter Glt(Ph).
Q37285230Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.
Q98188537Functional consequences of SLC1A3 mutations associated with episodic ataxia 6
Q33749190Functional diversity of excitatory amino acid transporters: ion channel and transport modes.
Q30981324Functional expression, purification and high sequence coverage mass spectrometric characterization of human excitatory amino acid transporter EAAT2
Q44433358Functional hemichannels in astrocytes: a novel mechanism of glutamate release.
Q37012384Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1.
Q50722568Functional significance of N- and C-terminus of the amino acid transporters EAAC1 and ASCT1: characterization of chimeric transporters.
Q30595758Functions of glutamate transporters in the brain
Q21090476GABA and Glutamate Transporters in Brain
Q38478361GLAST But Not Least--Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain--Focus on GLAST/EAAT1.
Q35753519GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate
Q38821169GLT-1: The elusive presynaptic glutamate transporter
Q38840403Gating Charge Calculations by Computational Electrophysiology Simulations.
Q47923144Glial Glutamate Transporters as Signaling Molecules.
Q33734827Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion Conductance
Q48393584Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus.
Q48290868Glial glutamate transport as target for nitric oxide: consequences for neurotoxicity
Q45172682Glial glutamate transporter expression patterns in brains from multiple mammalian species
Q37929084Glial glutamate transporters: new actors in brain signaling.
Q74483165Glial signalling in response to neuronal activity in the leech central nervous system
Q32162281Glial transporters for glutamate, glycine and GABA I. Glutamate transporters
Q38852061Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury.
Q89460073Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions
Q47923107Glutamate Transporters in the Blood-Brain Barrier
Q38317269Glutamate Transporters/Na(+), K(+)-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake
Q34048502Glutamate as a neurotransmitter in the healthy brain
Q37077117Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia
Q40631940Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels
Q51977738Glutamate release in severe brain ischaemia is mainly by reversed uptake.
Q38034221Glutamate signaling in bone
Q30898028Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds
Q36832422Glutamate transporter currents in bergmann glial cells follow the time course of extrasynaptic glutamate
Q30484889Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland
Q31104740Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings
Q48391758Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
Q36745208Glutamate transporters in brain ischemia: to modulate or not?
Q33749196Glutamate transporters in kidney and brain
Q36995107Glutamate transporters: confining runaway excitation by shaping synaptic transmission
Q28190140Glutamate uptake
Q33506412Glutamate uptake triggers transporter-mediated GABA release from astrocytes
Q44781489Glutamate-induced inhibition of D-aspartate uptake in Müller glia from the retina
Q33902645Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus.
Q33578118H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
Q34537094Hetero-oligomerization of neuronal glutamate transporters
Q38978352Heterologously expressed GLT-1 associates in approximately 200-nm protein-lipid islands
Q50265028Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-maze in C57BL/6J mice.
Q38039082Hydrogen sulfide: role in ion channel and transporter modulation in the eye.
Q43984531Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT.
Q34099018Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter
Q41964712Identifying neurotransmitter spill-over in hippocampal field recordings
Q91810675Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors
Q37291406Impaired glutathione synthesis in neurodegeneration
Q36610296Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus
Q42443618Increased tonic activation of presynaptic metabotropic glutamate receptors in the rat supraoptic nucleus following chronic dehydration
Q28569538Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other
Q38954648Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders
Q42627103Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes
Q37314890Interactions of alkali cations with glutamate transporters
Q40256305Intersubunit interactions in EAAT4 glutamate transporters.
Q48192003Intracellular Na+ concentration influences short-term plasticity of glutamate transporter-mediated currents in neocortical astrocytes
Q36708535Intracellular gating in an inward-facing state of aspartate transporter Glt(Ph) is regulated by the movements of the helical hairpin HP2
Q30476660Intrinsic kinetics determine the time course of neuronal synaptic transporter currents
Q92090826Investigation of the allosteric coupling mechanism in a glutamate transporter homolog via unnatural amino acid mutagenesis
Q42118122Inward currents induced by ischemia in rat spinal cord dorsal horn neurons
Q37469808Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats.
Q77435045Ion-coupled neurotransmitter transport: thermodynamic vs. kinetic determinations of stoichiometry
Q44207688Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?
Q40832141Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2.
Q37647972Isolation of glutamate transport-coupled charge flux and estimation of glutamate uptake at the climbing fiber-Purkinje cell synapse
Q38353584Isothermal titration calorimetry of ion-coupled membrane transporters
Q41682921K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+.
Q37382033Kidney amino acid transport.
Q58693980Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh
Q43889431Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia
Q36124870Lactate rescues neuronal sodium homeostasis during impaired energy metabolism
Q35217160Large collective motions regulate the functional properties of glutamate transporter trimers
Q41235978Listening to neurotransmitter transporters.
Q47833180Localization and function of five glutamate transporters cloned from the salamander retina
Q42000851Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh
Q48393613Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel.
Q38343025Maintaining the presynaptic glutamate supply for excitatory neurotransmission
Q33885249Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
Q37368667Mechanism of transport modulation by an extracellular loop in an archaeal excitatory amino acid transporter (EAAT) homolog
Q26830761Mechanisms of glutamate transport
Q48288174Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells.
Q43619747Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase
Q100464156Millisecond dynamics of an unlabeled amino acid transporter
Q74271437Modulation by zinc of the glutamate transporters in glial cells and cones isolated from the tiger salamander retina
Q41837512Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
Q48309130Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange
Q44100440Modulation of glial glutamate transport through cell interactions with the extracellular matrix
Q28589307Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1
Q36323509Molecular Determinants of Substrate Specificity in Sodium-coupled Glutamate Transporters.
Q35744207Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter
Q43219312Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members.
Q33639627Molecular dynamics simulations of membrane proteins
Q27314841Molecular dynamics simulations of the mammalian glutamate transporter EAAT3
Q34228641Molecular mechanisms of neurotransmitter release
Q47804164Molecular pharmacology and physiology of glutamate transporters in the central nervous system
Q30485857Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter
Q28202617Multivesicular release at climbing fiber-Purkinje cell synapses
Q37405027Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.
Q43807517Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter
Q33792891Na+ interactions with the neutral amino acid transporter ASCT1.
Q36302344Neuroenergetics and the kinetic design of excitatory synapses.
Q64108001Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions
Q37932454Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source
Q47566443Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive Behaviors.
Q37526061Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters
Q48692349Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism.
Q33893518Neuronal and glial glycine transporters have different stoichiometries
Q43770525Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells.
Q40073816Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance
Q46179370Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
Q33783651Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus
Q36366441Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Q38086728Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1).
Q36078674Neurotransmitter transport: models in flux
Q38105743Neurotransmitter transporters: structure meets function
Q28609231Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance
Q33233908Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.
Q42187526Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.
Q48637189New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter.
Q34865910New views of glutamate transporter structure and function: advances and challenges.
Q24647216Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4
Q41761189Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1.
Q33718901Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins
Q93142905Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model
Q34948160Novel dicarboxylate selectivity in an insect glutamate transporter homolog
Q41899521On the mechanism of proton transport by the neuronal excitatory amino acid carrier 1.
Q34985714Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate
Q48257377Optical detection of synaptically induced glutamate transport in hippocampal slices.
Q37678650PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology
Q44087171Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes
Q37236922Pentameric assembly of a neuronal glutamate transporter
Q41976273Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels
Q36205994Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica
Q90473558Physiology of Astroglia
Q49917383Physiology of Astroglia.
Q34200400Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1.
Q43100679Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia
Q36479703Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1
Q33940888Proximity of transmembrane segments 5 and 8 of the glutamate transporter GLT-1 inferred from paired cysteine mutagenesis
Q43810165Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis
Q43263308Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake
Q47302876Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter
Q48456314Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet.
Q43142319Reassessment of models of facilitated transport and cotransport
Q44281872Receptor occupancy limits synaptic depression at climbing fiber synapses.
Q36272554Reciprocal Regulation of Mitochondrial Dynamics and Calcium Signaling in Astrocyte Processes
Q42859910Rectifying rectifier channels in Huntington disease
Q35814637Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site
Q36076622Regional distribution of sodium-dependent excitatory amino acid transporters in rat spinal cord
Q35541864Regulation and Modulation of pH in the Brain
Q47923131Regulation of Glutamate Transporter Expression in Glial Cells
Q39628906Regulation of glial glutamate transporters by C-terminal domains.
Q48250313Regulation of hippocampal synaptic strength by glial xCT.
Q47988844Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns
Q43978513Relationship between zinc and neurotransmitters released into the amygdalar extracellular space
Q35874999Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.
Q47599606Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex
Q64118530Role of Glutamatergic Excitotoxicity in Neuromyelitis Optica Spectrum Disorders
Q35836052Role of glial amino acid transporters in synaptic transmission and brain energetics
Q38240290Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity
Q37495425SLC1 glutamate transporters
Q38921131SNAT3-mediated glutamine transport in perisynaptic astrocytes in situ is regulated by intracellular sodium.
Q48918632SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.
Q100454971Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding
Q44844957Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices.
Q35027454Serine-O-sulphate transport by the human glutamate transporter, EAAT2.
Q40800452Serotonin and norepinephrine transporters: possible relationship between oligomeric structure and channel modes of conduction.
Q42208360Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters
Q34085522Signalling mechanisms: a decade of signalling.
Q28235525Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters
Q46622476Sodium signals in cerebellar Purkinje neurons and Bergmann glial cells evoked by glutamatergic synaptic transmission
Q93016064Solute carrier transporters: the metabolic gatekeepers of immune cells
Q34488964Stoichiometry and kinetics of the high-affinity H+-coupled peptide transporter PepT2.
Q40993675Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.
Q34460241Strategies for metabolic exchange between glial cells and neurons
Q47754240Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Q89818867Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
Q33652145Structural features of the glutamate transporter family
Q35952945Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh.
Q42356946Structure and allosteric inhibition of excitatory amino acid transporter 1.
Q36785016Structure and function of sodium-coupled GABA and glutamate transporters
Q30032687Structure of a glutamate transporter homologue from Pyrococcus horikoshii
Q55291849Structure-Function Relationship of Transporters in the Glutamate-Glutamine Cycle of the Central Nervous System.
Q33803749Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters.
Q48906935Substrate turnover by transporters curtails synaptic glutamate transients.
Q39542421Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4
Q43509256Substrate-induced rearrangements in glutamate-transporter homologs
Q42748422Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2.
Q43543018Substrates and temperature differentiate ion flux from serotonin flux in a serotonin transporter
Q24555048Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance
Q34451962Synaptic activation of glutamate transporters in hippocampal astrocytes
Q36651510Synaptic activation of presynaptic glutamate transporter currents in nerve terminals
Q37382205Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases.
Q35836084Synaptic signaling between neurons and glia.
Q37268387Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes
Q43254544Synaptically induced sodium signals in hippocampal astrocytes in situ
Q43509876Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers
Q39958018Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3
Q27002488Targeting glutamate uptake to treat alcohol use disorders
Q37118714Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1
Q30486743The Concise Guide to PHARMACOLOGY 2013/14: transporters
Q98178410The Human SLC1A5 Neutral Amino Acid Transporter Catalyzes a pH-Dependent Glutamate/Glutamine Antiport, as Well
Q36381942The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2.
Q61917209The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter
Q34146588The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle
Q40785086The anion conductance of the glutamate transporter EAAC1 depends on the direction of glutamate transport
Q30504089The central cavity in trimeric glutamate transporters restricts ligand diffusion
Q44776061The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.
Q48181225The concentration of synaptically released glutamate outside of the climbing fiber-Purkinje cell synaptic cleft
Q36724927The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1.
Q33922825The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.
Q34031064The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation
Q34807368The dual-function glutamate transporters: structure and molecular characterisation of the substrate-binding sites
Q37321027The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters
Q33546981The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype
Q79953349The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits
Q35581543The glutamate and neutral amino acid transporter family: physiological and pharmacological implications
Q40825711The glutamate synapse as a therapeutical target: perspectives for the future.
Q36493590The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism
Q24652058The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits
Q27863346The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Q28207856The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
Q34528594The importance of the excitatory amino acid transporter 3 (EAAT3)
Q81627683The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses
Q48410468The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia.
Q30090226The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1.
Q46202485The role of cation binding in determining substrate selectivity of glutamate transporters
Q37741854The role of excitatory amino acid transporters in cerebral ischemia
Q36137988The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
Q41693925The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders
Q33818616The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
Q34988343The significance of molecular slips in transport systems
Q50647152The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion.
Q43251824The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.
Q57084779The uncoupled chloride conductance of a bacterial glutamate transporter homolog
Q26864995Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling
Q30484136Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter
Q45253642Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices
Q38861849Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors.
Q36356823Transcriptome analysis of the key role of GAT2 gene in the hyper-accumulation of copper in the oyster Crassostrea angulata
Q36156739Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1.
Q35153966Transport domain unlocking sets the uptake rate of an aspartate transporter.
Q37312799Transport dynamics in a glutamate transporter homologue.
Q26747176Transport mechanism of a glutamate transporter homologue GltPh
Q42488868Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate
Q45989370Transporter-mediated replacement of extracellular glutamate for GABA in the developing murine neocortex.
Q93551720Transporters
Q37047085Tuning the ion selectivity of glutamate transporter-associated uncoupled conductances
Q35010990Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter
Q42968242Update on the neurobiology of schizophrenia: a role for extracellular microdomains.
Q96231026Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog
Q37971367Vesicular and plasma membrane transporters for neurotransmitters
Q44336888Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.
Q36877990Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2
Q48788762Voltage-independent sodium-binding events reported by the 4B-4C loop in the human glutamate transporter excitatory amino acid transporter 3.
Q28346060Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
Q34922230Why glycine transporters have different stoichiometries.
Q42911386Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters
Q43607719Zn(2+) inhibits the anion conductance of the glutamate transporter EEAT4.
Q37054864pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract.

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