Interactions of alkali cations with glutamate transporters

scientific article published on January 2009

Interactions of alkali cations with glutamate transporters is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1098/RSTB.2008.0246
P932PMC publication ID2674104
P698PubMed publication ID18977733
P5875ResearchGate publication ID23445269

P2093author name stringMichael P Kavanaugh
David C Holley
P2860cites workCharacterization of the glutamate transporter in retinal cones of the tiger salamanderQ46887772
Assessing scoring functions for protein-ligand interactionsQ47429905
Active transport of L-glutamate by membrane vesicles isolated from rat brainQ48159648
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel.Q48393613
Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel.Q48786174
Ion fluxes associated with excitatory amino acid transport.Q49042016
Valence screening of water in protein crystals reveals potential Na+ binding sites.Q52310289
The uncoupled chloride conductance of a bacterial glutamate transporter homologQ57084779
Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signalingQ57612071
Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cellsQ71574125
Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamanderQ71959012
Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporterQ74291078
The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunitsQ79953349
ASCT-1 is a neutral amino acid exchanger with chloride channel activityQ24319141
An excitatory amino-acid transporter with properties of a ligand-gated chloride channelQ24323343
Homology modeling of the cation binding sites of Na+K+-ATPaseQ24541473
The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunitsQ24652058
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporterQ27643578
Glutamate uptakeQ28190140
Flux coupling in a neuronal glutamate transporterQ28293091
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each otherQ28569538
Structure of a glutamate transporter homologue from Pyrococcus horikoshiiQ30032687
Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporterQ30484136
Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within millisecondsQ30898028
Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.Q33233908
Simple Allosteric Model for Membrane PumpsQ34242760
Synaptic activation of glutamate transporters in hippocampal astrocytesQ34451962
Predicting Ca(2+)-binding sites in proteinsQ35004486
Found: Na(+) and K(+) binding sites of the sodium pumpQ35180282
Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signalingQ36100152
Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1Q36295999
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporterQ36296014
Role of Na+ and K+ in enzyme functionQ36610450
Glutamate transporters: confining runaway excitation by shaping synaptic transmissionQ36995107
Retinal glial cell glutamate transporter is coupled to an anionic conductanceQ37631116
The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cellsQ39587671
Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters.Q40687672
Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2.Q40832141
Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.Q40993675
Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ionsQ43691960
The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.Q44776061
P433issue1514
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)155-161
P577publication date2009-01-01
P1433published inPhilosophical Transactions of the Royal Society BQ2153239
P1476titleInteractions of alkali cations with glutamate transporters
P478volume364

Reverse relations

cites work (P2860)
Q90047711Allosteric gate modulation confers K+ coupling in glutamate transporters
Q34611048An entropic mechanism of generating selective ion binding in macromolecules
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Q27677232Binding thermodynamics of a glutamate transporter homolog
Q40753199Biochemical characterization of the C4-dicarboxylate transporter DctA from Bacillus subtilis
Q36137442Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter
Q36409591Computational Studies of Glutamate Transporters
Q27683834Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
Q36526395Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positions
Q34068453Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.
Q35556342Free energy simulations of ligand binding to the aspartate transporter Glt(Ph).
Q34099018Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter
Q43235905Introduction. The blurred boundary between channels and transporters
Q42000851Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh
Q33885249Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
Q26830761Mechanisms of glutamate transport
Q27314841Molecular dynamics simulations of the mammalian glutamate transporter EAAT3
Q38105743Neurotransmitter transporters: structure meets function
Q34865910New views of glutamate transporter structure and function: advances and challenges.
Q34948160Novel dicarboxylate selectivity in an insect glutamate transporter homolog
Q34200400Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1.
Q35814637Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site
Q39628906Regulation of glial glutamate transporters by C-terminal domains.
Q34009584Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse
Q30504089The central cavity in trimeric glutamate transporters restricts ligand diffusion
Q37321027The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters
Q30090226The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1.

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