Allosteric gate modulation confers K+ coupling in glutamate transporters

scientific article published on 10 September 2019

Allosteric gate modulation confers K+ coupling in glutamate transporters is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMBJ.2019101468
P932PMC publication ID6769379
P698PubMed publication ID31506973

P50authorChristoph FahlkeQ39064875
Jan-Philipp MachtensQ58237481
Daniel KortzakQ58237506
P2093author name stringIngo Weyand
Arne Franzen
Claudia Alleva
David Ewers
Meike I Zimmermann
P2860cites workArginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporterQ74291078
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Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporterQ79998918
MSMExplorer: Data Visualizations for Biomolecular DynamicsQ112108932
Mechanisms of glutamate transportQ26830761
Molecular dynamics simulations of the mammalian glutamate transporter EAAT3Q27314841
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporterQ27643578
Transport mechanism of a bacterial homologue of glutamate transporters.Q27658257
Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA poreQ27658373
Coupled ion binding and structural transitions along the transport cycle of glutamate transportersQ27683834
Crystal structure of a substrate-free aspartate transporterQ27685469
Flux coupling in a neuronal glutamate transporterQ28293091
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each otherQ28569538
OPM: orientations of proteins in membranes databaseQ29616317
Structure of a glutamate transporter homologue from Pyrococcus horikoshiiQ30032687
The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1.Q30090226
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g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbationQ30387289
Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within millisecondsQ30898028
Pyrococcus horikoshii sp. nov., a hyperthermophilic archaeon isolated from a hydrothermal vent at the Okinawa Trough.Q32051778
Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.Q33233908
Potentials of mean force and permeabilities for carbon dioxide, ammonia, and water flux across a Rhesus protein channel and lipid membranes.Q33683724
Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1.Q34200400
EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptakeQ34268987
Mechanism of chloride interaction with neurotransmitter:sodium symporters.Q34664153
Novel dicarboxylate selectivity in an insect glutamate transporter homologQ34948160
Identification of a chloride ion binding site in Na+/Cl -dependent transporters.Q35921659
Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporterQ36137442
Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1Q36479703
Intracellular gating in an inward-facing state of aspartate transporter Glt(Ph) is regulated by the movements of the helical hairpin HP2Q36708535
The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1.Q36724927
Induced fit substrate binding to an archeal glutamate transporter homologueQ37049486
Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemiaQ37077117
Physical properties of lipid bilayers from EPR spin labeling and their influence on chemical reactions in a membrane environmentQ37250985
Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.Q37285230
Transport dynamics in a glutamate transporter homologue.Q37312799
Interactions of alkali cations with glutamate transportersQ37314890
The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transportersQ37321027
Protonation of key acidic residues is critical for the K⁺-selectivity of the Na/K pumpQ38672573
Molecular physiology of EAAT anion channels.Q38674534
Insights into the function of ion channels by computational electrophysiology simulationsQ38732214
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters.Q38740041
Gating Charge Calculations by Computational Electrophysiology Simulations.Q38840403
Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4Q39542421
Mechanisms of anion conduction by coupled glutamate transportersQ41506333
Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulationsQ41930764
Direct visualization of glutamate transporter elevator mechanism by high-speed AFM.Q42175041
Structure and allosteric inhibition of excitatory amino acid transporter 1.Q42356946
Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTkQ42368299
Impaired K+ binding to glial glutamate transporter EAAT1 in migraineQ42638648
Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph).Q43115899
Markov models of molecular kinetics: generation and validationQ43633887
Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transportersQ43702405
Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?Q44207688
Accuracy and convergence of free energy differences calculated from nonequilibrium switching processesQ46447636
Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brainQ48832388
Binding order of substrates to the (sodium + potassium ion)-coupled L-glutamic acid transporter from rat brainQ48871901
Ion fluxes associated with excitatory amino acid transport.Q49042016
Glutamate release in severe brain ischaemia is mainly by reversed uptake.Q51977738
An efficient method for sampling the essential subspace of proteins.Q52310950
Rates of diffusional exchange between small cells and a measuring patch pipette.Q54389976
Conformational heterogeneity of the aspartate transporter GltPhQ62035571
Binding and transport of D-aspartate by the glutamate transporter homolog GltQ64058308
Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchangeQ71985002
P433issue19
P304page(s)e101468
P577publication date2019-09-10
P1433published inThe EMBO JournalQ1278554
P1476titleAllosteric gate modulation confers K+ coupling in glutamate transporters
P478volume38

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Q98188537Functional consequences of SLC1A3 mutations associated with episodic ataxia 6cites workP2860

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