| scholarly article | Q13442814 |
| P2093 | author name string | K Saito | |
| J Elia | |||
| A Lackner | |||
| M P Heyes | |||
| J S Crowley | |||
| M A Demitrack | |||
| L E Davis | |||
| M J Kruesi | |||
| L A Dilling | |||
| M Der | |||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | inflammation | Q101991 |
| P304 | page(s) | 1249-73 | |
| P577 | publication date | 1992-10-01 | |
| P1433 | published in | Brain | Q897386 |
| P1476 | title | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease | |
| P478 | volume | 115 ( Pt 5) |
| Q34674629 | "WHAT'S BUGGING THE GUT IN OCD?" A REVIEW OF THE GUT MICROBIOME IN OBSESSIVE-COMPULSIVE DISORDER. |
| Q37718532 | 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future. |
| Q41561714 | 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). |
| Q52721984 | A Critical Evaluation of Wet Biomarkers for Huntington's Disease: Current Status and Ways Forward. |
| Q33592717 | A link between central kynurenine metabolism and bone strength in rats with chronic kidney disease |
| Q27734730 | A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase |
| Q37179033 | A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders |
| Q45296971 | Activated immune system in patients with Huntington's disease |
| Q35689877 | Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans |
| Q24629807 | Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects |
| Q92381661 | Age- and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease |
| Q39399401 | Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease |
| Q45756457 | Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid |
| Q35618064 | Alternative kynurenic acid synthesis routes studied in the rat cerebellum |
| Q37254521 | An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation |
| Q34414219 | An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics |
| Q44866401 | Antibiotic-mediated release of tumour necrosis factor alpha and norharman in patients with hospital-acquired pneumonia and septic encephalopathy |
| Q72532813 | Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system |
| Q37580090 | Association of TNFSF15 polymorphism with irritable bowel syndrome |
| Q35231633 | Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C |
| Q47562518 | Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome |
| Q48402823 | Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry |
| Q30419650 | Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid |
| Q36129070 | Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression |
| Q33751166 | CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression |
| Q38794551 | Cerebrospinal Fluid Biomarkers for Huntington's Disease |
| Q82029827 | Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex |
| Q48818748 | Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. |
| Q28085041 | Changing the face of kynurenines and neurotoxicity: therapeutic considerations |
| Q24297366 | Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+ |
| Q73706192 | Concentrations of quinolinic acid in cerebrospinal fluid measured by gas chromatography and electron-impact ionisation mass spectrometry. Age-related changes in a paediatric reference population |
| Q36901111 | Connecting inflammation with glutamate agonism in suicidality. |
| Q44537870 | Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems |
| Q82493306 | Creatine and pyruvate prevent behavioral and oxidative stress alterations caused by hypertryptophanemia in rats |
| Q26740330 | Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis |
| Q38422675 | Current neurological observations and complications of dengue virus infection. |
| Q73310237 | Dapsone prevents morphological lesions and lipid peroxidation induced by quinolinic acid in rat corpus striatum |
| Q45764821 | Decreased plasma ratio of tryptophan to competing large neutral amino acids in human immunodeficiency virus type 1 infected subjects: possible implications for development of neuro-psychiatric disorders |
| Q79356267 | Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase |
| Q44100268 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation |
| Q24310976 | Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types |
| Q33972544 | Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder |
| Q35235620 | Does ketamine have anti-suicidal properties? Current status and future directions |
| Q35763798 | Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria |
| Q94538473 | Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion |
| Q35026406 | Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest |
| Q49056953 | Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain. |
| Q38938249 | Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH |
| Q38728657 | Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons. |
| Q48521011 | Effects of N omega-nitro-L-arginine and L-arginine on quinolinic acid-induced lipid peroxidation. |
| Q36915988 | Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria |
| Q45783844 | Effects of chronic zidovudine administration on CNS function and virus burden after perinatal SIV infection in rhesus monkeys |
| Q48348044 | Effects of electromagnetic fields on the levels of biogenic amine metabolites, quinolinic acid, and beta-endorphin in the cerebrospinal fluid of dairy cows |
| Q44068688 | Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain |
| Q90680244 | Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice |
| Q47099897 | Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease |
| Q28262656 | Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis |
| Q33816563 | Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder |
| Q34156448 | Endogenous kynurenines as targets for drug discovery and development |
| Q37580731 | Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines |
| Q31425931 | Endogenous neurotoxins from tryptophan |
| Q44447910 | Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis |
| Q42065141 | Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists |
| Q31389226 | Enhanced tryptophan degradation in systemic lupus erythematosus |
| Q39653727 | Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1. |
| Q36437682 | Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease |
| Q34277561 | Fatigue in patients with lung cancer is related with accelerated tryptophan breakdown |
| Q42585205 | Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD). |
| Q22253175 | Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase |
| Q36442043 | Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment |
| Q38896504 | Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism |
| Q93090922 | Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer's disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity |
| Q40924999 | Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain |
| Q35749186 | Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation |
| Q38119270 | Genes and functional GI disorders: from casual to causal relationship. |
| Q37526428 | Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application |
| Q43657062 | Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages |
| Q64255204 | HS suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma |
| Q89878318 | Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice |
| Q42985603 | Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS. |
| Q28379366 | Human microglia convert l-tryptophan into the neurotoxin quinolinic acid |
| Q36793974 | IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. |
| Q37722886 | Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection |
| Q26853328 | Immunomodulatory properties of cacao extracts - potential consequences for medical applications |
| Q42372999 | Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina |
| Q42682085 | Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice |
| Q45295711 | Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease |
| Q64923604 | Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer. |
| Q41520870 | Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism |
| Q34147377 | Inflammation-associated depression: from serotonin to kynurenine |
| Q38212575 | Inflammation: a mechanism of depression? |
| Q37089253 | Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications |
| Q44578156 | Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels |
| Q37892975 | Involvement of kynurenines in Huntington's disease and stroke-induced brain damage |
| Q36003890 | Involvement of quinolinic acid in AIDS dementia complex |
| Q34705346 | Is Tourette's syndrome an autoimmune disease? |
| Q46492101 | Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. |
| Q59112359 | Kynurenic Acid Content in Selected Culinary Herbs and Spices |
| Q36482308 | Kynurenic Acid Metabolism in Various Types of Brain Pathology in HIV-1 Infected Patients |
| Q33572850 | Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies |
| Q24338794 | Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35 |
| Q48187630 | Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization |
| Q36554693 | Kynurenic acid in plasma and endometrium in bitches with pyometra. |
| Q35101846 | Kynurenic acid is a nutritional cue that enables behavioral plasticity |
| Q37339253 | Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions. |
| Q46748707 | Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro |
| Q26782867 | Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology |
| Q32065766 | Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis |
| Q35054916 | Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration |
| Q48241209 | Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery |
| Q43718624 | Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection |
| Q34633683 | Kynurenine pathway metabolites in humans: disease and healthy States |
| Q38861843 | Kynurenines and Glutamate: Multiple Links and Therapeutic Implications |
| Q39315645 | Kynurenines and other novel therapeutic strategies in the treatment of dementia |
| Q48345142 | Kynurenines impair energy metabolism in rat cerebral cortex |
| Q32148941 | Kynurenines in the CNS: from endogenous obscurity to therapeutic importance |
| Q34317484 | Kynurenines in the CNS: recent advances and new questions. |
| Q27003296 | Kynurenines in the mammalian brain: when physiology meets pathology |
| Q37623378 | Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases. |
| Q37772582 | Kynurenines, neurodegeneration and Alzheimer's disease |
| Q34260092 | Kynurenines: from the perspective of major psychiatric disorders |
| Q34116625 | L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase |
| Q28361167 | Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system |
| Q36750975 | Laboratory evaluations in HIV-1-associated cognitive/motor complex. |
| Q93381880 | Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation |
| Q38859547 | Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms |
| Q56767225 | Mechanisms of interferon-alpha-induced depressive symptoms |
| Q59489064 | Melatonin reduces oxidative neurotoxicity due to quinolinic acid: |
| Q46005961 | Metabolites associated with risk of developing mobility disability in the Health, Aging and Body Composition Study. |
| Q36681392 | Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques |
| Q64252507 | Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases |
| Q36937939 | Microglia/macrophage-derived inflammatory mediators galectin-3 and quinolinic acid are elevated in cerebrospinal fluid from newborn infants after birth asphyxia |
| Q33809556 | Microglial Activation in the Pathogenesis of Huntington's Disease |
| Q90049859 | Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development |
| Q93145936 | Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status |
| Q64244961 | Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition |
| Q50334911 | Modulation of Tryptophan and Serotonin Metabolism as a Biochemical Basis of the Behavioral Effects of Use and Withdrawal of Androgenic-Anabolic Steroids and Other Image- and Performance-Enhancing Agents. |
| Q90043237 | Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum |
| Q43690548 | Neonatal asphyxia in rats: acute effects on cerebral kynurenine metabolism |
| Q30475641 | Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice |
| Q36532151 | Neuroimmune-endocrine crosstalk in schizophrenia and mood disorders |
| Q60907801 | Neurological and Inflammatory Manifestations in Sjögren's Syndrome: The Role of the Kynurenine Metabolic Pathway |
| Q37140513 | Neurometabolic effects of ACTH on free amino compounds in opsoclonus-myoclonus syndrome |
| Q61959959 | Neuroprotective Effect of Myxobacterial Extracts on Quinolinic Acid-Induced Toxicity in Primary Human Neurons |
| Q33379228 | Neurotoxic and neuroprotective metabolites of kynurenine in patients with renal cell carcinoma treated with interferon-alpha: course and relationship with psychiatric status |
| Q38137691 | Neurotranmission systems as targets for toxicants: a review |
| Q48357956 | Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity |
| Q48164911 | Nomega-nitro-L-arginine, a nitric oxide synthase inhibitor, antagonizes quinolinic acid-induced neurotoxicity and oxidative stress in rat striatal slices |
| Q30276671 | Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin |
| Q43811221 | Novel protein modification by kynurenine in human lenses |
| Q43558984 | Oligodendrocyte killing by quinolinic acid in vitro |
| Q37831342 | Pathobiological targets of depression. |
| Q37378691 | Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders |
| Q53195506 | Phytochemical treatments target kynurenine pathway induced oxidative stress. |
| Q36905419 | Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. |
| Q40763916 | Porcine choroid plexus epithelial cells induce Streptococcus suis bacteriostasis in vitro |
| Q45750235 | Progressive dendritic pathology in cynomolgus macaques infected with simian immunodeficiency virus |
| Q36799653 | Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus |
| Q35611425 | Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains |
| Q40578220 | Quinolinic acid in neurological disease: opportunities for novel drug discovery. |
| Q24814135 | Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. |
| Q77853798 | Quinolinic acid, alpha-picolinic acid, fusaric acid, and 2,6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer |
| Q43621641 | Quinolinic acid-iron(ii) complexes: slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction |
| Q35883306 | Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. |
| Q46242157 | Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of l-4-chlorokynurenine in healthy volunteers |
| Q33871711 | Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway |
| Q33975360 | Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. |
| Q34359001 | Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains |
| Q59356525 | Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV |
| Q46913599 | Role of paroxetine in interferon-alpha-induced immune and behavioural changes in male Wistar rats. |
| Q77744202 | S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase |
| Q45005186 | Salivary cytokines in healthy adolescent girls: Intercorrelations, stability, and associations with serum cytokines, age, and pubertal stage |
| Q73530605 | Selective metabolism of kynurenine in the spleen in the absence of indoleamine 2,3-dioxygenase induction |
| Q36679249 | Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. |
| Q89582857 | Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder |
| Q34306709 | Simian immunodeficiency virus model of HIV-induced central nervous system dysfunction |
| Q36142281 | Sleep disorders are long-term sequelae of both bacterial and viral meningitis |
| Q36067322 | Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression? |
| Q52052175 | Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis |
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| Q35607818 | Stochastic resonance activity influences serum tryptophan metabolism in healthy human subjects |
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| Q38103448 | The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. |
| Q33485236 | The excitotoxin quinolinic acid induces tau phosphorylation in human neurons |
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| Q37059457 | The involvement of astrocytes and kynurenine pathway in Alzheimer's disease. |
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