The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

scientific article

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1038300056
P356DOI10.1007/S11011-008-9118-1
P698PubMed publication ID19085093
P5875ResearchGate publication ID23665862

P50authorMario MajQ17306224
Michael MaesQ30504745
Giulia PeriniQ56754406
Marta KuberaQ58737559
P2093author name stringJens Noraberg
Bernard Lerer
Petr Bob
Joe Hibbeln
Raz Yirmyia
Stefan Brene
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Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression.Q51996803
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Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections.Q52165694
Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder.Q53573170
Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.Q53784738
Leukocyte subsets in treatment-resistant major depression.Q54051056
An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in chronic fatigue syndrome (CFS) and major depression: evidence that nitrosative stress is another factor underpinning the comorbidity between major depression aQ56767133
The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depressionQ56767137
Lowered Serum Dipeptidyl Peptidase IV Activity is Associated with Depressive Symptoms and Cytokine Production in Cancer Patients Receiving Interleukin-2-Based ImmunotherapyQ56767259
Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depressionQ56767269
The inflammatory response following delivery is amplified in women who previously suffered from major depression, suggesting that major depression is accompanied by a sensitization of the inflammatory response systemQ56767280
In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stressQ56767303
Negative Immunoregulatory Effects of Antidepressants Inhibition of Interferon-γ and Stimulation of Interleukin-10 SecretionQ56767354
Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugsQ56767386
Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipidsQ56767442
Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizersQ56767487
The monocyte-T-lymphocyte hypothesis of major depressionQ56767511
Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depressionQ56767551
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depressionQ56767554
Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depressionQ57221581
Interleukin-1β Released by gp120 Drives Neural Death through Tyrosine Phosphorylation and Trafficking of NMDA ReceptorsQ57372490
Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effectsQ60492133
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapyQ60727624
P433issue1
P921main subjectneurodegenerationQ1755122
P304page(s)27-53
P577publication date2008-12-16
P1433published inMetabolic Brain DiseaseQ15764352
P1476titleThe inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
P478volume24

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Q35903305Effect of pegylated interferon-α-2a treatment on mental health during recent hepatitis C virus infection
Q35812335Effects of Antidepressants on DSP4/CPT-Induced DNA Damage Response in Neuroblastoma SH-SY5Y Cells
Q55177615Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study.
Q34726433Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample.
Q40630941Evaluating [11C]PBR28 PET for Monitoring Gut and Brain Inflammation in a Rat Model of Chemically Induced Colitis.
Q53836933Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education.
Q60910510Faecal Short Chain Fatty Acids Profile is Changed in Polish Depressive Women
Q38721869Ferulic acid suppresses expression of tryptophan metabolic key enzyme indoleamine 2, 3-dioxygenase via NFκB and p38 MAPK in lipopolysaccharide-stimulated microglial cells
Q47280324Fish oil and depression: The skinny on fats
Q52360936Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.
Q34309215Four research findings that will change what we think about perinatal depression
Q36889750Fractalkine Attenuates Microglial Cell Activation Induced by Prenatal Stress
Q47695435Gap junction channels as potential targets for the treatment of major depressive disorder
Q39015204Gastrointestinal comorbidities which complicate the treatment of anorexia nervosa
Q54280525Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells.
Q37109491Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis
Q41994130Gestational diabetes exacerbates maternal immune activation effects in the developing brain.
Q42673840Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice
Q27024383Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction
Q36442019Glucocorticoids, cytokines and brain abnormalities in depression
Q56672658Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
Q39438471High level interleukin-6 in the medium of human pancreatic cancer cell culture suppresses production of neurotransmitters by PC12 cell line.
Q40184390High serum total cholesterol is associated with suicide mortality in Japanese women
Q90479791IDO and Kynurenine Metabolites in Peripheral and CNS Disorders
Q38315020Immune mechanisms linked to depression via oxidative stress and neuroprogression
Q36908139Immune system inflammation in cocaine dependent individuals: implications for medications development
Q51761592Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review.
Q52654781In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life.
Q48475221Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients.
Q48119273Increased neuroplasticity may protect against cardiovascular disease
Q92188579Indigenous Subarctic Food Systems in Transition: Amino Acid Composition (Including Tryptophan) in Wild-Harvested and Processed Meats
Q92639608Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders
Q38199487Individual differences in the neurobiology of social stress: implications for depression-cardiovascular disease comorbidity
Q39098530Inflammation and depression: a causal or coincidental link to the pathophysiology?
Q35233681Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis.
Q60950197Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study
Q48852269Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions
Q43191760Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood
Q26775316Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances
Q39445647Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis
Q34159724Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis.
Q36832872Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses
Q47773748Intestinal microbiome-gut-brain axis and irritable bowel syndrome.
Q60473680Ionic Glutamate Modulators in Depression (Zinc, Magnesium)
Q34499830Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide.
Q28741691Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
Q92069767Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects
Q57157635Linking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implications
Q34775703Lipid peroxidation and depressed mood in community-dwelling older men and women
Q37016842Long-Term Use of Selective Serotonin Reuptake Inhibitors and Risk of Glaucoma in Depression Patients
Q47663680Low Vs. High Alcohol: Central Benefits Vs. Detriments.
Q36211387Lower Urinary Tract Symptoms, Depression, Anxiety and Systemic Inflammatory Factors in Men: A Population-Based Cohort Study
Q52318289Major Differences in Neurooxidative and Neuronitrosative Stress Pathways Between Major Depressive Disorder and Types I and II Bipolar Disorder.
Q38623015Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice.
Q37863685Marine omega-3 fatty acids and mood disorders--linking the sea and the soul. 'Food for Thought' I.
Q57469273Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines
Q44746502Medical comorbidity in recurrent versus first-episode depressive patients
Q46916643Metabolic and glutathione redox markers associated with brain-derived neurotrophic factor in depressed african men and women: evidence for counterregulation?
Q46327960Methylene blue and its analogues as antidepressant compounds.
Q41699494Microglia: An Interface between the Loss of Neuroplasticity and Depression
Q34091504Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice
Q34554827Migraine associated with gastrointestinal disorders: review of the literature and clinical implications
Q90263636Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer's disease
Q22241418Minocycline: therapeutic potential in psychiatry
Q61449989Mitochondria, Microglia, and the Immune System-How Are They Linked in Affective Disorders?
Q42919834Moclobemide exerts anti-inflammatory effect in lipopolysaccharide-activated primary mixed glial cell culture.
Q37668003Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection.
Q38049302Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
Q34340306N-3 (omega-3) Fatty acids in postpartum depression: implications for prevention and treatment
Q26849307N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence
Q93160297NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice
Q58596391Near-Infrared Photobiomodulation Combined with Coenzyme Q for Depression in a Mouse Model of Restraint Stress: Reduction in Oxidative Stress, Neuroinflammation, and Apoptosis
Q47586564Neurobiological parameters in quantitative prediction of treatment outcome in schizophrenic patients
Q92485063Neurocognitive SuperAging in Older Adults Living With HIV: Demographic, Neuromedical and Everyday Functioning Correlates
Q34103068Neuroendocrine and immune contributors to fatigue
Q37532906Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression
Q35758842Neuroimmune endocrine effects of antidepressants
Q34369407Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies.
Q37116106Neuroinflammation, neurodegeneration, and depression.
Q36451817Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.
Q64972277Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases.
Q35991228Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour
Q48958182Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences.
Q37978196New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.
Q48239049Nipple pain during breastfeeding with or without visible trauma.
Q35237227Of sound mind and body: depression, disease, and accelerated aging
Q21284717Omega-3 fatty acids and depression: scientific evidence and biological mechanisms
Q37953519Omega-3 fatty acids and ginger in maternal health: pharmacology, efficacy, and safety
Q26738789Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Q43105430Oxidative stress and major depression
Q38189557Oxidative stress markers in affective disorders.
Q57074528PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress
Q42580192Pain and opioid use in chronic liver disease: optimal treatment must address the mental health care needs of the patient
Q27000066Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability
Q28384484Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling
Q37831342Pathobiological targets of depression.
Q37763086Pathogenesis and diagnosis of hepatic encephalopathy
Q26749017Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review
Q38230661Perfusion deficits, inflammation and aging precipitate depressive behaviour
Q47367738Peripheral Immune System Adaptations and Motivation for Alcohol in Non-Dependent Problem Drinkers
Q34660056Peripheral and Central Mechanisms of Stress Resilience
Q37176590Peripheral biomarkers in animal models of major depressive disorder
Q42511911Peripheral immune system suppression in early abstinent alcohol-dependent individuals: Links to stress and cue-related craving
Q48061279Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice
Q90585666Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression
Q36310734Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder
Q48685238Plasma magnesium levels and treatment outcome in depressed patients
Q95315172Plasma redox and inflammatory patterns during major depressive episodes: a cross-sectional investigation in elderly patients with mood disorders
Q35170354Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells
Q48267490Prodromal depression in pancreatic cancer: retrospective evaluation on ten patients
Q92228613Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress
Q33932852Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
Q43269486Prospective analysis of depression during peginterferon and ribavirin therapy of chronic hepatitis C: results of the Virahep-C study
Q34942602Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial
Q39757070Psychosis post corona radiata and lentiform nucleus infarction
Q92994173Reduced grey matter volume in frontal and temporal areas in depression: contributions from voxel-based morphometry study
Q26768609Reelin-Related Disturbances in Depression: Implications for Translational Studies
Q93104581Relationship between the Intake of n-3 Polyunsaturated Fatty Acids and Depressive Symptoms in Elderly Japanese People: Differences According to Sex and Weight Status
Q38290421Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression.
Q38681297Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants
Q26786208Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression
Q38136672Research review: the role of cytokines in depression in adolescents: a systematic review
Q67874336Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.
Q37593869Role of inflammatory cytokines in depression: Focus on interleukin-1β.
Q33578486Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials
Q28728766Selective hyper-responsiveness of the interferon system in major depressive disorders and depression induced by interferon therapy
Q58794277Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis
Q38266209Shared neurobiological pathways between type 2 diabetes and depressive symptoms: a review of morphological and neurocognitive findings
Q90680584Significant Decrease in Hippocampus and Amygdala Mean Diffusivity in Treatment-Resistant Depression Patients Who Respond to Electroconvulsive Therapy
Q36067322Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression?
Q47096228Stress & the gut-brain axis: Regulation by the microbiome
Q91921027Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health
Q35713356Stress, depression and Parkinson's disease
Q48281041Stress-Induced Alterations of Immune Profile in Animals Suffering by Tau Protein-Driven Neurodegeneration.
Q48371668Structural brain changes associated with depressive symptoms in the elderly with Alzheimer's disease
Q38822609Supervised, Vigorous Intensity Exercise Intervention for Depressed Female Smokers: A Pilot Study
Q37044561Systemic immune activation leads to neuroinflammation and sickness behavior in mice
Q36851815Systemic inflammation, depression and obstructive pulmonary function: a population-based study
Q38038284Targeting IL-1 in depression
Q38189135Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
Q38024740Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression
Q60445723Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures
Q27004490Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date
Q38901677The Immune System and the Role of Inflammation in Perinatal Depression.
Q26783012The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments
Q35563633The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors.
Q92460762The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression
Q34343458The association of depression and anxiety with pain: a study from NESDA
Q99402135The complex interactions amongst serotonin, insulin, leptin and glycolipid metabolic parameters in human obesity
Q33887233The diagnosis of depression: current and emerging methods
Q42209744The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats
Q42754301The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats
Q38711065The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
Q38860400The effects of a probiotic formulation (Lactobacillus rhamnosus and L. helveticus) on developmental trajectories of emotional learning in stressed infant rats.
Q33715064The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
Q36493625The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).
Q34536698The impact of GPX1 on the association of groundwater selenium and depression: a Project FRONTIER study
Q38004705The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
Q35945930The role of cytokines and hot flashes in perimenopausal depression
Q38103493The role of inflammatory cytokines on the aetiopathogenesis of depression
Q47560623The sinonasal microbiota, neural signaling, and depression in chronic rhinosinusitis
Q59137339The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours
Q64944036Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature.
Q38454097Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Q42750430Traumatic stress, dissociation, and limbic irritability in patients with unipolar depression being treated with SSRIs
Q64066641Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review
Q39181179Understanding the role of serotonin in psychiatric diseases
Q48039424Unpredictable Chronic Mild Stress Paradigm Established Effects of Pro- and Anti-inflammatory Cytokine on Neurodegeneration-Linked Depressive States in Hamsters with Brain Endothelial Damages.
Q48690651Urinary biopyrrins: potential biomarker for monitoring of the response to treatment with anxiolytics.
Q34590922Vascular pathology and blood-brain barrier disruption in cognitive and psychiatric complications of type 2 diabetes mellitus
Q42856763Venlafaxine inhibits apoptosis of hippocampal neurons by up-regulating brain-derived neurotrophic factor in a rat depression model.
Q49022902Vitamin D status in patients with MS is negatively correlated with depression, but not with fatigue
Q34233708Zinc and the ERK kinases in the developing brain.
Q37025484Zinc homeostasis and neurodegenerative disorders
Q44039584β-Amyloid induced effects on cholinergic, serotonergic, and dopaminergic neurons is differentially counteracted by anti-inflammatory drugs

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