Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial

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Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.9758/CPN.2014.12.3.180
P932PMC publication ID4293162
P698PubMed publication ID25598820
P5875ResearchGate publication ID271219868

P50authorMichael BerkQ30504747
Buranee KanchanatawanQ96233092
Nathan DowlingQ96250734
Lesley BerkQ58456831
Melanie Maree AshtonQ60473818
Gin MalhiQ89872646
P2093author name stringMichael Maes
Atapol Sughondhabirom
Chee Ng
Olivia May Dean
Sookjareon Tangwongchai
P2860cites workMinocycline: therapeutic potential in psychiatryQ22241418
A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophreniaQ28263942
Altered expression of neurotrophic factors in patients with major depressionQ28271088
Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.Q51984734
Lower serum vitamin E concentrations in major depressionQ56767310
Possible antidepressant effect of minocyclineQ70996349
Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patientsQ74349181
A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.Q33769000
Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2Q34019667
Clinical relevance of the neurotrophins and their receptorsQ34484451
Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine.Q34574117
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depressionQ34904703
Antidepressant drugs and cytokines in mood disordersQ35018733
Cytokines and major depressionQ36031971
Does minocycline have antidepressant effect?Q37082204
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticityQ37699054
Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factorsQ37799094
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neuronsQ40379051
Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cellsQ40565950
Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogressionQ42716476
Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study.Q43157808
Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells.Q43291649
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatmentsQ43568192
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitorsQ44773988
Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depressionQ44945159
Escitalopram dose-response revisited: an alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depressionQ45024354
Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice.Q45920274
Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat.Q46137586
Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemiaQ46253405
Minocycline as adjunctive therapy for schizophrenia: an open-label studyQ46330964
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharideQ46442760
Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damageQ46464808
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar ratsQ46474101
Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activityQ46484407
Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicityQ46829569
Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depressionQ46921439
Sample size calculations for clinical pharmacology studiesQ47209592
Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline.Q48107443
Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocyclineQ48155067
Possible antipsychotic effects of minocycline in patients with schizophreniaQ48400463
Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine.Q48472593
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder.Q48732134
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectmajor depressive disorderQ42844
placeboQ269829
minocyclineQ415336
P304page(s)180-188
P577publication date2014-12-26
P1433published inClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of NeuropsychopharmacologyQ26842559
P1476titleProtocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial
P478volume12

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cites work (P2860)
Q64078160Abnormalities in Inflammatory Cytokines Confer Susceptible to Chronic Neuropathic Pain-related Anhedonia in a Rat Model of Spared Nerve Injury
Q47704592Adjunctive minocycline treatment for major depressive disorder: A proof of concept trial.
Q60610921Anti-inflammatory Agents for the Treatment of Depression in the Light of Comorbid Cardiovascular Disease
Q64078190Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats
Q39183235Do Statins Have Antidepressant Effects?
Q26798929Glia in the cytokine-mediated onset of depression: fine tuning the immune response
Q42378870Immuno-psychiatry: an agenda for clinical practice and innovative research
Q40208014Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
Q37310533Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment.
Q37310528Inflammation in Depression and the Potential for Anti-Inflammatory Treatment
Q47745353Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities
Q34549390Investigational drugs in recent clinical trials for treatment-resistant depression
Q47559443Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis.
Q92212858Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Q38885617Role of Inflammation in Suicide: From Mechanisms to Treatment
Q36253980The Gut-Brain Axis in Healthy Females: Lack of Significant Association between Microbial Composition and Diversity with Psychiatric Measures
Q35819780The Microbiome in Mental Health: Potential Contribution of Gut Microbiota in Disease and Pharmacotherapy Management
Q35246024The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Q47785792Therapeutic strategies for treatment of inflammation-related depression.

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