Abstract is: Alessio Ciulli FRSC (born in Firenze, 22 July 1977) is an Italian British biochemist. Currently, he is the Professor of Chemical & Structural Biology at the School of Life Sciences, University of Dundee, when he founded and directs Dundee' new Centre for Targeted Protein Degradation (CeTPD). He is also the scientific co-founder and advisor of Amphista Therapeutics.
| human | Q5 |
| P6178 | Dimensions author ID | 01320324504.79 |
| P8446 | Gateway to Research person ID | 0D8E8879-0792-49DD-9598-3984A6BEA513 |
| P2671 | Google Knowledge Graph ID | /g/11c6dkdnp_ |
| P1960 | Google Scholar author ID | yTciKqYAAAAJ |
| P496 | ORCID iD | 0000-0002-8654-1670 |
| P3829 | Publons author ID | 2815816 |
| P1053 | ResearcherID | A-6279-2011 |
| P1153 | Scopus author ID | 8514807400 |
| P10861 | Springer Nature person ID | 01320324504.79 |
| P166 | award received | Fellow of the Royal Society of Edinburgh | Q5438598 |
| P69 | educated at | University of Cambridge | Q35794 |
| P108 | employer | University of Dundee | Q1249005 |
| P735 | given name | Alessio | Q17501848 |
| Alessio | Q17501848 | ||
| P463 | member of | Royal Society of Edinburgh | Q117467 |
| P106 | occupation | researcher | Q1650915 |
| P21 | sex or gender | male | Q6581097 |
| Q89289670 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation |
| Q27657770 | A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry |
| Q41899570 | Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. |
| Q27657559 | Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase |
| Q27681973 | Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121 |
| Q92616532 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design |
| Q36206467 | Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis. |
| Q54932292 | Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery |
| Q26740037 | Chemical genetics approaches for selective intervention in epigenetics |
| Q90267927 | Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation" |
| Q27643575 | Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity |
| Q26777298 | Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions |
| Q92955269 | Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader |
| Q111442197 | Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins |
| Q112637998 | Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms |
| Q27674729 | Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface |
| Q101215612 | E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones |
| Q92929502 | Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand |
| Q47324161 | Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)- |
| Q91439050 | Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions |
| Q42217007 | Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. |
| Q38673230 | Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds |
| Q27652313 | Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate |
| Q27679154 | Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery |
| Q36336273 | Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach |
| Q27681373 | Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions? |
| Q61449114 | Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7 |
| Q46144594 | Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements |
| Q27679000 | Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases |
| Q30366295 | NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes |
| Q38668610 | New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. |
| Q56814027 | Nucleophile Selectivity of Chorismate-Utilizing Enzymes |
| Q55017940 | Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. |
| Q27660249 | Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase |
| Q28822022 | Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition |
| Q34553512 | Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods |
| Q91565780 | Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design |
| Q64244987 | RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response |
| Q64117684 | Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader |
| Q39107376 | Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies. |
| Q64269515 | SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate |
| Q41457619 | Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica |
| Q38837561 | Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology. |
| Q64235007 | Spy vs. spy: selecting the best reporter for F NMR competition experiments |
| Q98211758 | Stereoselective synthesis of allele-specific BET inhibitors |
| Q36306106 | Structural basis of PROTAC cooperative recognition for selective protein degradation |
| Q64935699 | Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. |
| Q27666987 | Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis |
| Q91349553 | Structure-Based Design of a Macrocyclic PROTAC |
| Q27640584 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities |
| Q38646896 | Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases |
| Q57167826 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase |
| Q48105865 | Target validation: Switching domains |
| Q40988449 | Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni |
| Q52358811 | Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach. |
| Q27680754 | Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain |
| Q27677509 | Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction |
| Q46556463 | The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound |
| Q52323183 | Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. |
| Q112314228 | Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity |
| Q27643619 | pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study |
| Alessio Ciulli | wikipedia |
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