Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model

scientific article published in July 2001

Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0704146
P932PMC publication ID1572853
P698PubMed publication ID11454657
P5875ResearchGate publication ID11886519

P2093author name stringK Mori
T Matsuda
E Lee
A Baba
K Takuma
R Enomoto
P2860cites workBiochemical pathways of caspase activation during apoptosisQ33804316
Glutamate receptors in glia: new cells, new inputs and new functionsQ33953259
Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle toneQ35874511
Neuronal and glial apoptosis after traumatic spinal cord injury.Q36868349
Functional receptors for neurotransmitters on astroglial cellsQ39148279
Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS.Q40802862
Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell lineQ40904210
Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity.Q41039902
Na(+)-Ca2+ exchanger: physiology and pharmacology.Q41508961
Ca2+/calmodulin-dependent cyclic GMP phosphodiesterase activity in granule neurons and astrocytes from rat cerebellumQ42436925
Cerebral white matter is highly vulnerable to ischemiaQ42522490
Role of Na(+)-Ca2+ exchanger in agonist-induced Ca2+ signaling in cultured rat astrocytesQ42525114
Inhibition by ibudilast of leukotriene D4-induced formation of inositol phosphates in guinea-pig lungQ42562441
Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosisQ46083438
The influence of pH on cellular calcium influx during ischemiaQ48141454
Pharmacological effects of ibudilast on cerebral circulation: a PET studyQ48279586
Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca2+] and [H+] in the hippocampus during recovery from short-term, transient ischemiaQ48442632
Selective glial vulnerability following transient global ischemia in rat brainQ48463130
Pituitary adenylyl cyclase-activating peptide stimulates extracellular signal-regulated kinase 1 or 2 (ERK1/2) activity in a Ras-independent, mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cellsQ48638484
Pharmacologically-distinct subsets of astroglia can be identified by their calcium response to neuroligandsQ48825547
Heat shock protects cultured rat astrocytes in a model of reperfusion injuryQ48892096
Ibudilast reduces intracellular calcium elevation induced by in vitro ischaemia in gerbil hippocampal slicesQ49037474
Effect of ibudilast: a novel antiasthmatic agent, on airway hypersensitivity in bronchial asthmaQ68214580
Mode of cerebral vasodilating action of KC-404 in isolated canine basilar arteryQ70291827
Anti-thrombotic effect of KC-404, a novel cerebral vasodilatorQ70305651
Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic ratsQ70777998
Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytesQ71354094
Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neuronsQ71519068
Nitroprusside and cyclic GMP stimulate Na(+)-Ca2+ exchange activity in neuronal preparations and cultured rat astrocytesQ72261129
Ibudilast, an anti-allergic and cerebral vasodilator, modulates superoxide production in human neutrophilsQ72414963
Cultured rat astrocytes possess Na(+)-Ca2+ exchangerQ72630595
Intracellular ascorbic acid inhibits the Na(+)-Ca2+ exchanger in cultured rat astrocytesQ72632390
CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor productionQ73098621
Apoptosis in Ca2 + reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF-kappaB activationQ73265113
Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell deathQ73760182
T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathwayQ73943216
Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanismQ73989944
Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytesQ74509768
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondriaQ77669580
Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signalingQ78094837
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P304page(s)841-8
P577publication date2001-07-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleIbudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model
P478volume133

Reverse relations

cites work (P2860)
Q43777343Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore
Q40346320Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells
Q44077103Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes
Q34642112Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
Q38921778Ibudilast for the treatment of multiple sclerosis
Q37636159Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease
Q37849347Inflammation and depression: why poststroke depression may be the norm and not the exception.
Q36104649Ischemia-induced programmed cell death in astrocytes
Q80600933Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger
Q92405022Novel Molecular Leads for the Prevention of Damage and the Promotion of Repair in Neuroimmunological Disease
Q90284868Signal Transduction of Improving Effects of Ibudilast on Methamphetamine Induced Cell Death
Q58027445Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis
Q92511375Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment
Q41771736The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain
Q41913461The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson's disease.
Q39271545Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis

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