T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway

scientific article published on 01 June 2000

T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-2999(00)00334-4
P698PubMed publication ID10876016

P50authorM TanabeQ62610192
P2093author name stringMori K
Fujita T
Lee E
Matsuda T
Kimura Y
Koyama Y
Baba A
Takuma K
Yamamuro A
P2860cites workA study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acidQ26778512
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruptionQ28290282
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteinsQ29617438
Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.Q34462515
Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factorQ36233580
Parallel signal processing among mammalian MAPKsQ40501929
Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell deathQ40981560
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Signal transduction by the neurotrophin receptorsQ41382912
Na(+)-Ca2+ exchanger: physiology and pharmacology.Q41508961
Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis.Q41521959
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyondQ41596068
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injuryQ42816281
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survivalQ42828483
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophyQ46517609
Reduction of cortical infarction and impairment of apoptosis in NGF-transgenic mice subjected to permanent focal ischemiaQ47913171
The influence of pH on cellular calcium influx during ischemiaQ48141454
Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia.Q48298173
The effects of T-588, a novel cognitive enhancer, on noradrenaline uptake and release in rat cerebral cortical slicesQ48422666
Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca2+] and [H+] in the hippocampus during recovery from short-term, transient ischemiaQ48442632
NGF delays rather than prevents the cholinergic terminal damage and delayed neuronal death in the hippocampus after ischemiaQ48460653
Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte culturesQ48550930
In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-betaNGF.Q48660267
Effects of R(−)-1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino) ethoxy]ethanol hydrochloride (T-588), a novel cognitive enhancer, on noradrenaline release in rat cerebral cortical slicesQ48707439
Heat shock protects cultured rat astrocytes in a model of reperfusion injuryQ48892096
A new cognition-enhancing agent, (R)-(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions.Q52204295
Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.Q54102532
Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic ratsQ70777998
Nerve growth factor protects the neonatal brain against hypoxic-ischemic injuryQ70928177
Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytesQ71354094
MAP kinase cascade in astrocytesQ72387857
Cultured rat astrocytes possess Na(+)-Ca2+ exchangerQ72630595
Intracellular ascorbic acid inhibits the Na(+)-Ca2+ exchanger in cultured rat astrocytesQ72632390
Apoptosis in Ca2 + reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF-kappaB activationQ73265113
Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytesQ74509768
P433issue1
P921main subjectastrocyteQ502961
P304page(s)1-8
P577publication date2000-06-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleT-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway
P478volume399

Reverse relations

cites work (P2860)
Q34528244Aniracetam attenuates apoptosis of astrocytes subjected to simulated ischemia in vitro.
Q73098621CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production
Q44077103Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes
Q28343913Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model
Q37252016Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes
Q44676258Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.
Q34144706Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores
Q77956532T-588 enhances neurite outgrowth and choline acetyltransferase in cultured rat spinal ventral horn neurons
Q44676276T-588 protects motor neuron death against glutamate-induced neurotoxicity
Q44787549T-588 protects motor neuron death following axotomy
Q44525655T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus
Q34395516The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.

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