CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45

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CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45 is …
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scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1268989H
P356DOI10.1371/JOURNAL.PONE.0168989
P932PMC publication ID5221879
P698PubMed publication ID28068431

P2093author name stringChien-Heng Shen
Chih-Chuan Teng
Hsing-Chun Kuo
Kam-Fai Lee
Ko-Chao Lee
Meng-Chiao Hsieh
Wen-Shih Huang
Shui-Yi Tung
Yi-Hung Kuo
Cheng-Yi Huang
P2860cites workThe Hallmarks of CancerQ221226
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppressionQ22253431
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cQ24290118
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptorsQ24310559
Dietary histone deacetylase inhibitors: from cells to mice to manQ24641899
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45Q28199142
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsQ28257534
Differential regulation and properties of MAPKsQ28301932
THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTSQ29308301
MAPK cascade signalling and synaptic plasticityQ29619955
Proteomic analysis of the effects of baicalein on colorectal cancer cellsQ34249170
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Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkersQ37113145
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and BaicalinQ37323907
Redox control of the cell cycle in health and diseaseQ37510851
Targeting apoptosis pathways in cancer by Chinese medicineQ37777759
Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives.Q37863785
Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells.Q38203281
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosisQ38326924
Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascadeQ38785295
Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cellsQ39119584
CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stabilityQ39282085
The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.Q39334341
Baicalein inhibits the migration and invasive properties of human hepatoma cellsQ39498036
Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cellsQ39543648
Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progressionQ39869474
Synthesis and cytotoxic evaluation of certain 4-(phenylamino)furo[2,3-b]quinoline and 2-(furan-2-yl)-4-(phenylamino)quinoline derivativesQ40189850
Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c]quinoline derivativesQ40417917
CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.Q40493893
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repairQ42115350
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.Q45020400
GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activityQ78666533
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpointQ79710648
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)e0168989
P577publication date2017-01-01
P1433published inPLOS OneQ564954
P1476titleCIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45
P478volume12

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