Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade

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Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...741549S
P356DOI10.1371/JOURNAL.PONE.0041549
P932PMC publication ID3406039
P698PubMed publication ID22844498
P5875ResearchGate publication ID230586826

P50authorKanneboyina NagarajuQ27662260
Robert J. FreishtatQ39689151
P2093author name stringAngela S Benton
Andrew A Wiles
Matthew Sharron
Lindsay M Garvin
Mayya Geha
Claire E Hoptay
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Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survivalQ34017334
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.Q34120958
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosisQ34483368
Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort studyQ34545611
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generationQ36380942
Redox mechanisms of vascular cell dysfunction in sepsisQ36513069
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.Q37126477
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Immunodesign of experimental sepsis by cecal ligation and punctureQ37368111
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The platelet membrane glycoprotein IIb-IIIa complex.Q39195582
Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharidesQ39512262
Biphasic, organ-specific, and strain-specific accumulation of platelets induced in mice by a lipopolysaccharide from Escherichia coli and its possible involvement in shockQ39826933
Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanismsQ39890408
Sepsis and septic shock--a review of laboratory models and a proposalQ40290200
Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradationQ40506485
Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unitQ41461494
Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsisQ41992252
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunctionQ43029801
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Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsisQ43523332
Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathwayQ44597135
Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitisQ44639646
A central role for Bid in granzyme B-induced apoptosisQ45169973
Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis.Q45956998
Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosisQ46706728
Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig.Q46763608
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient miceQ48648759
Circulating endothelial cells in patients with septic shock.Q51365961
Intestinal platelet trapping after traumatic and septic shock. An early sign of sepsis and multiorgan failure in critically ill patients?Q51693482
Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independentQ57272605
Outcome of pediatric patients with multiple organ system failureQ70028501
Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathwayQ73246756
Comparative analysis of platelet isolation techniques for the in vivo study of the microcirculationQ73283374
Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shockQ73981728
Apoptosis in endometrial glandular and stromal cells in women with and without endometriosisQ74439718
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsisQ77855901
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcomeQ78602259
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
P304page(s)e41549
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titlePlatelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade
P478volume7

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Q99629654Antiplatelet Agents in Sepsis-Putting it all together: A Call to Action
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