Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms

scientific article

Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/09537100802503368
P698PubMed publication ID19172522

P50authorMichael BauerQ50638837
P2093author name stringMatthias Kohl
Jürg Hamacher
Ralf A Claus
Johannes Winning
Wolfgang Lösche
Julia Reichel
Hans Peter Deigner
Yvonne Eisenhut
P2860cites workClinical trials in severe sepsis with drotrecogin alfa (activated)Q21195024
Serial evaluation of the SOFA score to predict outcome in critically ill patientsQ28191384
Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirinQ28193127
Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient miceQ28193681
In vivo platelet response to lipopolysaccharide in mice: proposed method for evaluating new antiplatelet drugsQ28195590
Platelet function and pharmacologic inhibitionQ28200441
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits modelQ28212194
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic diseaseQ28218124
Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled cathetersQ28219906
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy menQ29619308
Time course of platelet counts in critically ill patients.Q33341888
Platelet function in sepsisQ33342364
Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU staysQ33375129
Platelets: signaling cells in the immune continuum.Q34342687
The evolving role of platelets in inflammation.Q35206747
Platelets in sepsisQ36270004
New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates.Q36425100
Biology and pharmacology of the platelet P2Y12 receptorQ36447310
Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injuryQ36667169
Platelets as mediators of inflammationQ36720126
Effects of anticoagulant strategies on activation of inflammation and coagulationQ36842724
The role of platelet CD154 in the modulation in adaptive immunityQ36961079
Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsisQ37035362
Platelet-derived microvesicles induce differential gene expression in monocytic cells: a DNA microarray studyQ40204179
Aspirin improves endothelial dysfunction in atherosclerosisQ42544568
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunctionQ43029801
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic painQ43917782
LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement systemQ44182927
Human endothelial impairment in sepsisQ44283078
Effect of prior pneumococcal vaccination on clinical outcome of hospitalized adults with community-acquired pneumococcal pneumonia.Q44703978
Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig.Q46763608
Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet-leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkersQ46830648
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)50-57
P577publication date2009-02-01
P1433published inPlateletsQ1573582
P1476titleAnti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms
P478volume20

Reverse relations

cites work (P2860)
Q38075209Acute pneumonia and the cardiovascular system.
Q99629654Antiplatelet Agents in Sepsis-Putting it all together: A Call to Action
Q37598223AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol
Q35211647Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis
Q35916354Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study
Q41365182Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study
Q33752498Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients
Q33394357Beyond thrombosis: the versatile platelet in critical illness
Q35952453Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis
Q47096645Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Q43098741Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel
Q30415074Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness
Q39114910Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients?
Q36018451Effect of Antiplatelet Therapy on Acute Respiratory Distress Syndrome and Mortality in Critically Ill Patients: A Meta-Analysis
Q30244785Effect of antiplatelet therapy on mortality and acute lung injury in critically ill patients: A systematic review and meta-analysis
Q45097939Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock
Q44367120Immunological biomarkers improve the accuracy of clinical risk models of infection in the acute phase of ischemic stroke.
Q33864069Inflammation and thrombosis in cardiovascular disease.
Q40896463Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Q38165517Lipid mediators in immune dysfunction after severe inflammation
Q34456208Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study
Q35088200Lower mortality rate in elderly patients with community-onset pneumonia on treatment with aspirin.
Q38005318Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.
Q35197476No significant detectable anti-infection effects of aspirin and statins in chronic obstructive pulmonary disease
Q89860277P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation
Q27013790PAMPs and DAMPs as triggers for DIC
Q38151563Pharmacology of the new P2Y12 receptor inhibitors: insights on pharmacokinetic and pharmacodynamic properties.
Q34298556Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates, from which bacteria subsequently escape.
Q84192794Platelet aggregation in severe sepsis
Q91962280Platelets Are Critical Key Players in Sepsis
Q47144868Platelets and Multi-Organ Failure in Sepsis
Q34590168Platelets as immune mediators: Their role in host defense responses and sepsis
Q28481577Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade
Q26853685Pneumonia, thrombosis and vascular disease
Q58992325Predictors of Disseminated Intravascular Coagulation in Patients with Septic Shock
Q33801302Prevalence, pathogenesis, therapy, and prevention of cardiovascular events in patients with community-acquired pneumonia
Q38629029Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
Q33894675Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
Q55018714The preventive effect of antiplatelet therapy in acute respiratory distress syndrome: a meta-analysis.
Q34277327The role of whole blood impedance aggregometry and its utilisation in the diagnosis and prognosis of patients with systemic inflammatory response syndrome and sepsis in acute critical illness
Q58698782Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia
Q33409092Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis
Q50115928Translational Implications of Platelets as Vascular First Responders
Q64086271Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study
Q36928258Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis

Search more.