Multiple actions of spinophilin regulate mu opioid receptor function

scientific journal article

Multiple actions of spinophilin regulate mu opioid receptor function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEURON.2008.02.006
P932PMC publication ID3115895
P698PubMed publication ID18439408
P5875ResearchGate publication ID5414349

P50authorPaul GreengardQ309979
Eric J. NestlerQ5386788
Rachael L. NeveQ108917624
P2093author name stringSumana Chakravarty
Venetia Zachariou
Lakshmi A. Devi
Ivone Gomes
Kassi Psifogeorgou
Patrick B. Allen
Joanna J. Charlton
P2860cites workMu opioid receptor: a gateway to drug addictionQ35803141
Morphine-activated opioid receptors elude desensitization by beta-arrestinQ36280218
Subcellular distribution of neurabin immunolabeling in primate prefrontal cortex: comparison with spinophilinQ39751237
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptorsQ40442171
Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptorsQ40648991
mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brainQ41054132
Separation of mu-opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures.Q44330114
Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activityQ44339547
Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.Q44341663
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machineryQ44345837
Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalizationQ44351622
Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization.Q44580806
Local gene knockdown in the brain using viral-mediated RNA interference.Q44666833
Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.Q44804066
In vivo regulation of extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphineQ44824322
Neuroscience of addictionQ44880443
An essential role for DeltaFosB in the nucleus accumbens in morphine actionQ46896171
Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responsesQ48445440
Distinct roles for spinophilin and neurabin in dopamine-mediated plasticityQ48590755
Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spinesQ24641883
Essential role for RGS9 in opiate actionQ24655663
Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5Q24670878
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeletonQ24685127
Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting proteinQ28138646
Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1Q28140793
RGS9-2 is a negative modulator of mu-opioid receptor functionQ28242513
Enhanced morphine analgesia in mice lacking beta-arrestin 2Q28504554
Spinophilin regulates the formation and function of dendritic spinesQ28513720
Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neuronsQ28575335
The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunitsQ28582944
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptorsQ28584983
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependenceQ28590279
Molecular basis of long-term plasticity underlying addictionQ29620539
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine actionQ30477757
Regulation of opioid receptor activitiesQ33601320
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.Q33873664
Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilinQ33931039
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuliQ34038682
Drug addictions. Molecular and cellular endpoints.Q34310836
Molecular and cellular basis of addictionQ34440561
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preferenceQ34479672
Neural systems underlying opiate addiction.Q34616139
Clinical pharmacology of opioids for painQ35024267
G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawalQ35046020
Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugsQ35172820
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectopioidQ427523
Protein phosphatase 1, regulatory subunit 9BQ21985869
P304page(s)238–247
P577publication date2008-04-24
P1433published inNeuronQ3338676
P1476titleMultiple actions of spinophilin regulate mu opioid receptor function
P478volume58

Reverse relations

cites work (P2860)
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Q34051639Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor
Q24302002Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence
Q37103755Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences.
Q37132059Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells
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Q44348688The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation
Q35046317Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes.

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