Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

scientific journal article

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1 is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10721541S
P356DOI10.1073/PNAS.1005794107
P932PMC publication ID3003004
P698PubMed publication ID21098667
P5875ResearchGate publication ID49629802

P50authorHervé LucheQ64786873
P2093author name stringJanardan K Reddy
Sandra Schmitz
Tilman Borggrefe
Xiaojing Yue
Melanie Stumpf
P2860cites workStructure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complexQ47401530
MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropesQ53641784
Cdk1 Triggers Association of RNA Polymerase to Cell Cycle Promoters Only after Recruitment of the Mediator by SBFQ57270117
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcriptionQ24306465
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashionQ24312064
Defects of the Heart, Eye, and Megakaryocytes in Peroxisome Proliferator Activator Receptor-binding Protein (PBP) Null Embryos Implicate GATA Family of Transcription FactorsQ28207790
Ras induces mediator complex exchange on C/EBP betaQ28242122
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiationQ28244293
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptorQ28250779
Dynamic regulation of pol II transcription by the mammalian Mediator complexQ28251057
GATA-1 associates with and inhibits p53.Q28504708
The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220Q28506353
Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethalityQ28507387
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1Q28508495
Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liverQ28585245
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone actionQ28589180
Inducible gene targeting in miceQ29614544
Association of the Mediator complex with enhancers of active genesQ33713593
Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous lociQ33783137
GATA1 function, a paradigm for transcription factors in hematopoiesisQ33823866
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.Q33922993
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal regionQ34144645
Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domainQ34393399
The mammalian Mediator complex and its role in transcriptional regulationQ34419211
Transcriptional control of erythropoiesis: emerging mechanisms and principles.Q34700755
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiationQ35901820
The mediator of RNA polymerase II.Q36029267
Mediator and the mechanism of transcriptional activationQ36129156
On a chromosome far, far away: LCRs and gene expressionQ36323088
Role of the mediator complex in nuclear hormone receptor signaling.Q36458032
BRG1 requirement for long-range interaction of a locus control region with a downstream promoter.Q37114798
The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongationQ38356015
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.Q39700519
Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation.Q40145000
Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expressionQ40155274
Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.Q40195835
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.Q40461679
The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoterQ42480421
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cellsQ44912795
P433issue50
P407language of work or nameEnglishQ1860
P921main subjectMediator complex subunit 1Q21985771
P304page(s)21541-21546
P577publication date2010-11-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSpecific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1
P478volume107

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cites work (P2860)
Q31166959Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair
Q24307814CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function
Q36104883Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations
Q35345626Essential role of Mediator subunit Med1 in invariant natural killer T-cell development
Q36826822Establishment of a Cell-Type-Specific Genetic Network by the Mediator Complex Component Med1
Q47127883Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
Q38776992LDB1-mediated enhancer looping can be established independent of mediator and cohesin
Q37608924MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Q34467453Med1 regulates meiotic progression during spermatogenesis in mice
Q38209734Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis
Q38698214Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene
Q37920021Mediator complex proteins are required for diverse developmental processes
Q36745036Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination
Q35617113MicroRNA 146 (Mir146) modulates spermatogonial differentiation by retinoic acid in mice
Q50093958Mouse Models of Erythropoiesis and Associated Diseases.
Q92716957PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4
Q43986858Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling
Q34695446SIMPL Enhancement of Tumor Necrosis Factor-α Dependent p65-MED1 Complex Formation Is Required for Mammalian Hematopoietic Stem and Progenitor Cell Function
Q35626108TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.
Q38558334The GATA factor revolution in hematology
Q28299679The Mediator complex and transcription regulation
Q37991879The Mediator complex in thyroid hormone receptor action
Q37122360Transcriptional Mechanisms Underlying Hemoglobin Synthesis
Q35351225Uncovering enhancer functions using the α-globin locus

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