Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke

scientific article (publication date: 2014)

Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...998807S
P356DOI10.1371/JOURNAL.PONE.0098807
P3181OpenCitations bibliographic resource ID4609266
P932PMC publication ID4049665
P698PubMed publication ID24911517
P5875ResearchGate publication ID262942902

P50authorYury M MorozovQ57401071
Yu-Yo SunQ88043534
P2093author name stringKoji Abe
Chia-Yi Kuan
Yikun Li
Pak H Chan
Dianer Yang
Pasko Rakic
Diana M Lindquist
R Scott Dunn
P2860cites workUpdate of the stroke therapy academic industry roundtable preclinical recommendationsQ29615508
Laser Doppler, speckle and related techniques for blood perfusion mapping and imagingQ31033320
Mouse model of in situ thromboembolic stroke and reperfusionQ33294333
A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?Q33938450
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagyQ33998182
The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011.Q34020415
Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner.Q34125992
Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic strokeQ34762997
Cerebral microvessel responses to focal ischemiaQ35193869
Preclinical stroke research--advantages and disadvantages of the most common rodent models of focal ischaemiaQ35589930
Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysisQ35707046
Adjunctive and alternative approaches to current reperfusion therapyQ35711810
A Mouse Model of Hemorrhagic Transformation by Delayed Tissue Plasminogen Activator Administration After In Situ Thromboembolic StrokeQ60589409
Studies on the specific fibrinolytic effect of human extrinsic (tissue-type) plasminogen activator in human blood and in various animal species in vitroQ71576230
Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulationQ83965053
Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary studyQ85034903
The two pathophysiologies of focal brain ischemia: implications for translational stroke researchQ36079309
Antioxidant strategies in the treatment of strokeQ36206823
Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.Q36736945
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.Q37361862
Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis?Q38050626
Protecting white matter from stroke injury.Q38065070
Safety, tolerability and pharmacokinetics of MCI-186 in patients with acute ischemic stroke: new formulation and dosing regimenQ38153555
Is misery perfusion still a predictor of stroke in symptomatic major cerebral artery disease?Q39612584
Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I.Q40381416
Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitroQ41837296
Human recombinant tissue-plasminogen activator (alteplase): why not use the 'human' dose for stroke studies in rats?Q41930720
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavengerQ41968726
Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic strokeQ42170505
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemiaQ42414802
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.Q43769073
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicentersQ44418044
Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brainQ44895277
Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brainQ46164241
Translational stroke research of the combination of thrombolysis and antioxidant therapyQ46170354
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activatorQ46190589
The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activatorQ46318985
The novel antioxidant edaravone: from bench to bedsideQ46591722
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brainQ46706351
Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET).Q47701499
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.Q48162562
Capillary patency after transient middle cerebral artery occlusion of 2 h durationQ48365225
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic strokeQ48593375
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectedaravoneQ335099
thrombotic strokeQ107538760
P304page(s)e98807
P577publication date2014-06-09
P1433published inPLOS OneQ564954
P1476titleSynergy of combined tPA-edaravone therapy in experimental thrombotic stroke
P478volume9

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cites work (P2860)
Q41866520A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Q90750947A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment
Q28389192Alteration of SLP2-like immunolabeling in mitochondria signifies early cellular damage in developing and adult mouse brain
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Q39169261Diabetic aggravation of stroke and animal models.
Q64080333IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats
Q30968894Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection
Q35516501Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses
Q47414741Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment
Q37394086Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat
Q40445057Towards reperfusion-centric preclinical stroke research: outside the box of "reperfusion injury"
Q28078744Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke
Q39031301Vascular inter-regulation of inflammation: molecular and cellular targets for CNS therapy

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