Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro

scientific article published on 17 October 2009

Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BRAINRES.2009.10.026
P932PMC publication ID2797401
P698PubMed publication ID19840779
P5875ResearchGate publication ID38021832

P2093author name stringKen Arai
Eng H Lo
Klaus van Leyen
Brian J Lee
Yasuhiro Egi
P2860cites workEffect of MCI-186 on brain edema in ratsQ44710629
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusionQ44921869
Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthaseQ45273958
Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brainQ46164241
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activatorQ46190589
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathwayQ46471698
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in ratsQ46514766
Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytesQ46851342
Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytesQ46915949
Stroke and neurovascular protectionQ46935433
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.Q48162562
Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cellsQ48304321
MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cellsQ48457955
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemiaQ48658567
Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.Q48719184
Molecular adaptation of vascular endothelial cells to oxidative stress.Q50784512
Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavengerQ80600933
NXY-059 for the treatment of acute ischemic strokeQ80768385
SAINT-I worked, but the neuroprotectant is not NXY-059Q80838619
Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neuronsQ21262040
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Neurovascular regulation in the normal brain and in Alzheimer's diseaseQ29619659
Novel lipoxygenase inhibitors as neuroprotective reagentsQ33303894
Thrombolysis in acute ischemic stroke: controlled trials and clinical experienceQ33758215
Reactive oxygen radicals in signaling and damage in the ischemic brainQ33930675
Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.Q33997543
Future of neuroprotection for acute stroke: in the aftermath of the SAINT trialsQ34617625
Mechanisms, challenges and opportunities in strokeQ35120144
Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusionQ36664577
Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.Q36677211
Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials.Q36705446
Cell-cell signaling in the neurovascular unitQ36801092
Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era.Q36810934
Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system diseaseQ37017486
Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survivalQ37184726
An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cellsQ37361396
Apoptotic mechanisms after cerebral ischemiaQ37381350
Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cellsQ39828570
A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.Q41096149
A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neuronsQ41904734
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavengerQ41968726
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicentersQ44418044
Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytesQ44536960
P921main subjectedaravoneQ335099
P304page(s)22-27
P577publication date2009-10-17
P1433published inBrain ResearchQ4955782
P1476titleEdaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
P478volume1307

Reverse relations

cites work (P2860)
Q33938450A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?
Q39427640A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model
Q37490657A novel method for inducing focal ischemia in vitro
Q33748058A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion
Q47782666A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies
Q30844551A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials
Q102054034ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation
Q37108311Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction
Q34256876Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures.
Q47782687Edaravone and its clinical development for amyotrophic lateral sclerosis
Q47802895Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK/Nrf2/HO-1 signaling pathway
Q38154741Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: a systematic review
Q39173214Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia
Q38847362Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress
Q40898682Edaravone offers neuroprotection for acute diabetic stroke patients
Q45846630Edaravone offers neuroprotection in a diabetic stroke model via inhibition of endoplasmic reticulum stress
Q34412765Edaravone promotes functional recovery after mechanical peripheral nerve injury
Q35181567Edaravone protect against retinal damage in streptozotocin-induced diabetic mice.
Q36649004Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke: a randomized controlled pilot study
Q34769939Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke
Q47700268How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?
Q36913914Lipoxygenase: an emerging target for stroke therapy
Q28393202Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective
Q38108307Nitric oxide donors as neuroprotective agents after an ischemic stroke-related inflammatory reaction
Q38202292Oligodendrocyte pathophysiology and treatment strategies in cerebral ischemia
Q37701407Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice
Q30968894Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection
Q91774684Protective Effect of Edaravone on Cyclophosphamide Induced Oxidative Stress and Neurotoxicity in Rats
Q50034037Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress.
Q28539510Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke
Q92343944Synthesis, Characterization and Antioxidant Properties of a New Lipophilic Derivative of Edaravone
Q37885608Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke.