Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection

scientific article (publication date: September 2014)

Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0003194
P3181OpenCitations bibliographic resource ID1621552
P932PMC publication ID4177854
P698PubMed publication ID25255101
P5875ResearchGate publication ID266082275

P50authorTanja SchirmeisterQ41507108
Heidrun MollQ21260927
Thomas ReinheckelQ56849298
P2093author name stringManfred B Lutz
Angela Schwarz
Bianca Röger
Iris J Gonzalez-Leal
P2860cites workHow quantitative differences in dendritic cell maturation can direct TH1/TH2-cell polarizationQ42044718
The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitorsQ42472217
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophagesQ43946923
CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cellsQ44219923
Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRsQ44576601
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.Q44862470
Tumor necrosis factor-alpha in combination with interferon-gamma, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotesQ44879905
CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis.Q44910134
Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against LeishmaniaQ44920559
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathwayQ45025138
Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.Q46018555
Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC.Q47644110
Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cellsQ49155579
Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice.Q50335825
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loadingQ24328923
Protease signalling: the cutting edgeQ26852301
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
ImageJ for microscopyQ28253317
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and perturbation of hair follicle cyclingQ28590536
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Activation of interleukin-6 gene expression through the NF-kappa B transcription factorQ28646310
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.Q29347297
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Dendritic cells: specialized and regulated antigen processing machinesQ29617085
Suppression of LPS-induced inflammatory responses in macrophages infected with LeishmaniaQ33669426
Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63.Q33728493
Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.Q34309555
Leishmania mexicana induces limited recruitment and activation of monocytes and monocyte-derived dendritic cells early during infectionQ34456673
A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium saltsQ34669706
Recombinant interleukin 12 cures mice infected with Leishmania majorQ36361742
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic modelQ36365507
Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant miceQ36366305
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligandsQ36370268
Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunityQ36404267
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentationQ36475793
Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunityQ36751431
Cathepsin S activity regulates antigen presentation and immunityQ37382422
Proteinases as virulence factors in Leishmania spp. infection in mammals.Q38032623
Nuclear cysteine cathepsin variants in thyroid carcinoma cellsQ39695008
Leishmania major parasites induced macrophage tolerance: implication of MAPK and NF-kappaB pathwaysQ39812406
Leishmania initially activates but subsequently down-regulates intracellular mitogen-activated protein kinases and nuclear factor-kappaB signaling in macrophagesQ39992739
Cathepsins are required for Toll-like receptor 9 responsesQ40029240
Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hostsQ40102605
Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activityQ40262609
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c miceQ40790202
The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharideQ40814428
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subverQ40913997
Regulation of macrophage IL-12 synthesis by Leishmania phosphoglycansQ40975281
Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.Q52520769
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.Q53615275
Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.Q54126242
Regulation of cathepsins S and L by cystatin F during maturation of dendritic cellsQ58323356
Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responsesQ58662838
Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotesQ63198732
Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturationQ63369608
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathologyQ73603855
Cathepsin B-inhibitor promotes the development of Th1 type protective T cells in mice infected with Leishmania majorQ73935322
Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cellsQ74494567
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cellsQ78516497
Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infectionQ79834668
Human primary dendritic cell subsets differ in their IL-12 release in response to Leishmania major infectionQ84736379
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectinfectious diseaseQ18123741
Leishmania majorQ1950715
P304page(s)e3194
P577publication date2014-09-25
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleCathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection
P478volume8

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cites work (P2860)
Q97652870B cell zone reticular cell microenvironments shape CXCL13 gradient formation
Q36018448Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner
Q90290679Cysteine Cathepsins in Tumor-Associated Immune Cells
Q52573372Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials.
Q35951395Exogenous Thyropin from p41 Invariant Chain Diminishes Cysteine Protease Activity and Affects IL-12 Secretion during Maturation of Human Dendritic Cells
Q50099421Friend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cells.
Q89622634Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination of Leishmania major in Mice
Q28550034Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)
Q92818657Re-thinking adaptive immunity in the beetles: Evolutionary and functional trajectories of lncRNAs

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