mechanistic target of rapamycin kinase

mammalian protein found in Homo sapiens

Wikidata entity: Q285613

Wikimedia Commons category is TOR serine-threonine kinases



P682 biological process ... Q18601 (long-term memory) long-term memory
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q567522 (anoikis) anoikis
P682 biological process ... Q14876077 (protein catabolic process) protein catabolic process
P682 biological process ... Q14876079 (TOR signaling) TOR signaling
P682 biological process ... Q14876080 (regulation of fatty acid beta-oxidation) regulation of fatty acid beta-oxidation
P682 biological process ... Q14876082 (regulation of actin cytoskeleton organization) regulation of actin cytoskeleton organization
P682 biological process ... Q14876083 (regulation of carbohydrate utilization) regulation of carbohydrate utilization
P682 biological process ... Q14876084 (negative regulation of cell size) negative regulation of cell size
P682 biological process ... Q828130 (signal transduction) signal transduction
P682 biological process ... Q921513 (social behavior) social behavior
P682 biological process ... Q1342838 (growth) growth
P682 biological process ... Q14330969 (brain development) brain development
P682 biological process ... Q210538 (DNA repair) DNA repair
P682 biological process ... Q14876088 (regulation of carbohydrate metabolic process) regulation of carbohydrate metabolic process
P682 biological process ... Q14876090 (cell projection organization) cell projection organization
P682 biological process ... Q14878798 (maternal process involved in female pregnancy) maternal process involved in female pregnancy
P682 biological process ... Q14881250 (negative regulation of calcineurin-NFAT signaling cascade) negative regulation of calcineurin-NFAT signaling cascade
P682 biological process ... Q14881716 (positive regulation of epithelial to mesenchymal transition) positive regulation of epithelial to mesenchymal transition
P682 biological process ... Q14881723 (cellular response to amino acid stimulus) cellular response to amino acid stimulus
P682 biological process ... Q14883343 (regulation of osteoclast differentiation) regulation of osteoclast differentiation
P682 biological process ... Q14897768 (regulation of protein kinase B signaling) regulation of protein kinase B signaling
P682 biological process ... Q14901696 (cardiac muscle cell development) cardiac muscle cell development
P682 biological process ... Q14902997 (spinal cord development) spinal cord development
P682 biological process ... Q14904367 (negative regulation of protein ubiquitination) negative regulation of protein ubiquitination
P682 biological process ... Q14906012 (regulation of GTPase activity) regulation of GTPase activity
P682 biological process ... Q14907708 (positive regulation of neuron death) positive regulation of neuron death
P682 biological process ... Q14912124 (positive regulation of phosphoprotein phosphatase activity) positive regulation of phosphoprotein phosphatase activity
P682 biological process ... Q14914536 (positive regulation of keratinocyte migration) positive regulation of keratinocyte migration
P682 biological process ... Q14916283 (mRNA stabilization) mRNA stabilization
P682 biological process ... Q14916357 (positive regulation of cell growth involved in cardiac muscle cell development) positive regulation of cell growth involved in cardiac muscle cell development
P682 biological process ... Q14330979 (positive regulation of neuron projection development) positive regulation of neuron projection development
P682 biological process ... Q14331037 (positive regulation of peptidyl-tyrosine phosphorylation) positive regulation of peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599765 (response to insulin) response to insulin
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14758905 (energy reserve metabolic process) energy reserve metabolic process
P682 biological process ... Q14758923 (activation of protein kinase B activity) activation of protein kinase B activity
P682 biological process ... Q14758937 (positive regulation of nitric oxide biosynthetic process) positive regulation of nitric oxide biosynthetic process
P682 biological process ... Q14761956 (positive regulation of lipid biosynthetic process) positive regulation of lipid biosynthetic process
P682 biological process ... Q14761970 (positive regulation of protein kinase B signaling) positive regulation of protein kinase B signaling
P682 biological process ... Q14818059 (multicellular organism growth) multicellular organism growth
P682 biological process ... Q14818081 (cellular response to hypoxia) cellular response to hypoxia
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q14819863 (positive regulation of cell death) positive regulation of cell death
P682 biological process ... Q1509074 (wound healing) wound healing
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q4374357 (post-embryonic development) post-embryonic development
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q7936605 (visual learning) visual learning
P682 biological process ... Q14820875 (response to activity) response to activity
P682 biological process ... Q14820884 (response to cocaine) response to cocaine
P682 biological process ... Q14851946 (regulation of protein phosphorylation) regulation of protein phosphorylation
P682 biological process ... Q14852005 (peptidyl-serine phosphorylation) peptidyl-serine phosphorylation
P682 biological process ... Q14852031 (heart morphogenesis) heart morphogenesis
P682 biological process ... Q14859586 (regulation of cell growth) regulation of cell growth
P682 biological process ... Q14859867 ('de novo' pyrimidine nucleobase biosynthetic process) 'de novo' pyrimidine nucleobase biosynthetic process
P682 biological process ... Q14859971 (positive regulation of oligodendrocyte differentiation) positive regulation of oligodendrocyte differentiation
P682 biological process ... Q14860776 (regulation of myelination) regulation of myelination
P682 biological process ... Q14860808 (response to nutrient) response to nutrient
P682 biological process ... Q14860834 (response to amino acid) response to amino acid
P682 biological process ... Q14860865 (negative regulation of protein phosphorylation) negative regulation of protein phosphorylation
P682 biological process ... Q14863108 (positive regulation of actin filament polymerization) positive regulation of actin filament polymerization
P682 biological process ... Q14863391 (negative regulation of autophagy) negative regulation of autophagy
P682 biological process ... Q14863394 (positive regulation of neuron maturation) positive regulation of neuron maturation
P682 biological process ... Q14863397 (peptidyl-threonine phosphorylation) peptidyl-threonine phosphorylation
P682 biological process ... Q14863701 (positive regulation of smooth muscle cell proliferation) positive regulation of smooth muscle cell proliferation
P682 biological process ... Q14863997 (positive regulation of neurogenesis) positive regulation of neurogenesis
P682 biological process ... Q14864123 (regulation of response to food) regulation of response to food
P682 biological process ... Q14864218 (positive regulation of translation) positive regulation of translation
P682 biological process ... Q14864283 (cardiac muscle contraction) cardiac muscle contraction
P682 biological process ... Q14864480 (cellular response to starvation) cellular response to starvation
P682 biological process ... Q14864514 (positive regulation of dendritic spine development) positive regulation of dendritic spine development
P682 biological process ... Q14864774 (response to morphine) response to morphine
P682 biological process ... Q14864807 (response to nutrient levels) response to nutrient levels
P682 biological process ... Q14864869 (positive regulation of glial cell proliferation) positive regulation of glial cell proliferation
P682 biological process ... Q14864952 (positive regulation of stress fiber assembly) positive regulation of stress fiber assembly
P682 biological process ... Q14865045 (ruffle organization) ruffle organization
P682 biological process ... Q14865064 (positive regulation of endothelial cell proliferation) positive regulation of endothelial cell proliferation
P682 biological process ... Q14865282 (regulation of protein kinase activity) regulation of protein kinase activity
P682 biological process ... Q14865932 (T-helper 1 cell lineage commitment) T-helper 1 cell lineage commitment
P682 biological process ... Q14873006 (positive regulation of transcription by RNA polymerase III) positive regulation of transcription by RNA polymerase III
P682 biological process ... Q14873901 (cardiac muscle tissue development) cardiac muscle tissue development
P682 biological process ... Q14874273 (germ cell development) germ cell development
P682 biological process ... Q14876070 (regulation of glycogen biosynthetic process) regulation of glycogen biosynthetic process
P682 biological process ... Q14876072 (positive regulation of lamellipodium assembly) positive regulation of lamellipodium assembly
P682 biological process ... Q14876073 (positive regulation of myotube differentiation) positive regulation of myotube differentiation
P682 biological process ... Q14876075 (negative regulation of macroautophagy) negative regulation of macroautophagy
P682 biological process ... Q14876078 (cellular response to nutrient levels) cellular response to nutrient levels
P682 biological process ... Q21095195 (regulation of cellular response to heat) regulation of cellular response to heat
P682 biological process ... Q21095237 (positive regulation of wound healing, spreading of epidermal cells) positive regulation of wound healing, spreading of epidermal cells
P682 biological process ... Q21095639 (cardiac cell development) cardiac cell development
P682 biological process ... Q21101041 (voluntary musculoskeletal movement) voluntary musculoskeletal movement
P682 biological process ... Q21102118 (cellular response to amino acid starvation) cellular response to amino acid starvation
P682 biological process ... Q21107241 (regulation of brown fat cell differentiation) regulation of brown fat cell differentiation
P682 biological process ... Q21107547 (regulation of cell size) regulation of cell size
P682 biological process ... Q21108778 (regulation of membrane permeability) regulation of membrane permeability
P682 biological process ... Q21111232 (regulation of macroautophagy) regulation of macroautophagy
P682 biological process ... Q21116183 (heart valve morphogenesis) heart valve morphogenesis
P682 biological process ... Q21131003 (positive regulation of transcription of nucleolar large rRNA by RNA polymerase I) positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
P682 biological process ... Q21132159 (negative regulation of muscle atrophy) negative regulation of muscle atrophy
P682 biological process ... Q21136464 (cellular response to leucine) cellular response to leucine
P682 biological process ... Q21469633 (cellular response to leucine starvation) cellular response to leucine starvation
P682 biological process ... Q22245118 (positive regulation of cytoplasmic translational initiation) positive regulation of cytoplasmic translational initiation
P682 biological process ... Q22250996 (regulation of translation at synapse, modulating synaptic transmission) regulation of translation at synapse, modulating synaptic transmission
P682 biological process ... Q22299998 (positive regulation of sensory perception of pain) positive regulation of sensory perception of pain
P682 biological process ... Q22300027 (positive regulation of skeletal muscle hypertrophy) positive regulation of skeletal muscle hypertrophy
P682 biological process ... Q22303220 (negative regulation of iodide transmembrane transport) negative regulation of iodide transmembrane transport
P682 biological process ... Q22303980 (TORC1 signaling) TORC1 signaling
P682 biological process ... Q22304686 (negative regulation of cholangiocyte apoptotic process) negative regulation of cholangiocyte apoptotic process
P682 biological process ... Q22304738 (positive regulation of eating behavior) positive regulation of eating behavior
P682 biological process ... Q22305561 (positive regulation of granulosa cell proliferation) positive regulation of granulosa cell proliferation
P682 biological process ... Q22305562 (positive regulation of cholangiocyte proliferation) positive regulation of cholangiocyte proliferation
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q83330 (lysosome) lysosome
P681 cell component ... Q79927 (endoplasmic reticulum) endoplasmic reticulum
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q899827 (endomembrane system) endomembrane system
P681 cell component ... Q12821248 (dendrite) dendrite
P681 cell component ... Q14329032 (endoplasmic reticulum membrane) endoplasmic reticulum membrane
P681 cell component ... Q14330611 (mitochondrial outer membrane) mitochondrial outer membrane
P681 cell component ... Q14878067 (organelle membrane) organelle membrane
P681 cell component ... Q14878285 (lysosomal membrane) lysosomal membrane
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14349519 (intracellular membrane-bounded organelle) intracellular membrane-bounded organelle
P681 cell component ... Q14598778 (Golgi membrane) Golgi membrane
P681 cell component ... Q14645696 (soma) soma
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14817968 (PML body) PML body
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q14876059 (phosphatidylinositol 3-kinase complex) phosphatidylinositol 3-kinase complex
P681 cell component ... Q14876060 (TORC1 complex) TORC1 complex
P681 cell component ... Q14876061 (TORC2 complex) TORC2 complex
P681 cell component ... Q22325163 (protein-containing complex) protein-containing complex
P681 cell component ... Q22327509 (postsynaptic cytosol) postsynaptic cytosol
P681 cell component ... Q24629101 (glutamatergic synapse) glutamatergic synapse
P373 Commons category String TOR serine-threonine kinases ???
P702 encoded by ... Q14876086 (MTOR) MTOR
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20FRAP1%20202288%20at%20fs.png ???
P527 has part(s) ... Q24771147 (Phosphatidylinositol 3-/4-kinase, catalytic domain) Phosphatidylinositol 3-/4-kinase, catalytic domain
P527 has part(s) ... Q24771855 (Phosphatidylinositol 3/4-kinase, conserved site) Phosphatidylinositol 3/4-kinase, conserved site
P527 has part(s) ... Q24773368 (FATC domain) FATC domain
P527 has part(s) ... Q24773556 (PIK-related kinase, FAT) PIK-related kinase, FAT
P527 has part(s) ... Q24721852 (FKBP12-rapamycin binding domain) FKBP12-rapamycin binding domain
P527 has part(s) ... Q24723463 (PIK-related kinase) PIK-related kinase
P527 has part(s) ... Q24769612 (Domain of unknown function DUF3385, target of rapamycin protein) Domain of unknown function DUF3385, target of rapamycin protein
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q14326094 (protein serine/threonine kinase activity) protein serine/threonine kinase activity
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14907297 (translation regulator activity) translation regulator activity
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14817984 (protein kinase binding) protein kinase binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14860854 (protein domain specific binding) protein domain specific binding
P680 molecular function ... Q14860862 (phosphoprotein binding) phosphoprotein binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14876066 (TFIIIC-class transcription factor complex binding) TFIIIC-class transcription factor complex binding
P680 molecular function ... Q14876069 (ribosome binding) ribosome binding
P680 molecular function ... Q22312857 (protein-containing complex binding) protein-containing complex binding
P361 part of ... Q24780424 (Armadillo-type fold) Armadillo-type fold
P361 part of ... Q41797838 (FKBP12-rapamycin binding domain superfamily) FKBP12-rapamycin binding domain superfamily
P361 part of ... Q41798033 (Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily) Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
P361 part of ... Q83133528 (FKBP12-rapamycin binding domain, protein family) FKBP12-rapamycin binding domain, protein family
P361 part of ... Q83134380 (PIK-related kinase family) PIK-related kinase family
P361 part of ... Q83138904 (Domain of unknown function DUF3385, target of rapamycin protein family) Domain of unknown function DUF3385, target of rapamycin protein family
P361 part of ... Q83140437 (Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family) Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family
P361 part of ... Q83141029 (FATC domain, protein family) FATC domain, protein family
P361 part of ... Q83141205 (PIK-related kinase, FAT family) PIK-related kinase, FAT family
P361 part of ... Q95353295 (Phosphatidylinositol 3/4-kinase, conserved site, protein family) Phosphatidylinositol 3/4-kinase, conserved site, protein family
P361 part of ... Q24723029 (serine/threonine-protein kinase TOR) serine/threonine-protein kinase TOR
P361 part of ... Q24724527 (Tetratricopeptide-like helical domain superfamily) Tetratricopeptide-like helical domain superfamily
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q24739502 (Armadillo-like helical) Armadillo-like helical
P129 physically interacts with ... Q421052 (everolimus) everolimus
P129 physically interacts with ... Q1232737 (perhexiline) perhexiline
P129 physically interacts with ... Q2151796 (ridaforolimus) ridaforolimus
P129 physically interacts with ... Q4835503 (dactolisib) dactolisib
P129 physically interacts with ... Q7699074 (temsirolimus) temsirolimus
P129 physically interacts with ... Q27074481 (apitolisib) apitolisib
P129 physically interacts with ... Q27074792 (azd-8055) azd-8055
P129 physically interacts with ... Q27078057 (indoximod) indoximod
P129 physically interacts with ... Q27078072 (sapanisertib) sapanisertib
P129 physically interacts with ... Q27088179 (omipalisib) omipalisib
P129 physically interacts with ... Q27089147 (vistusertib) vistusertib

External Ids
P705Ensembl protein IDENSP00000398745
P705Ensembl protein IDENSP00000354558
P705Ensembl protein IDENSP00000366034
P646Freebase ID/m/0860kt
P6366Microsoft Academic ID (discontinued)2777949483
P6366Microsoft Academic ID (discontinued)2910776440
P10283OpenAlex IDC2777949483
P10283OpenAlex IDC2909523446
P10283OpenAlex IDC86554907
P638PDB structure ID3FAP
P638PDB structure ID2FAP
P638PDB structure ID4JSX
P638PDB structure ID4JT6
P638PDB structure ID4JT5
P638PDB structure ID2RSE
P638PDB structure ID4JSV
P638PDB structure ID1NSG
P638PDB structure ID4FAP
P638PDB structure ID4JSN
P638PDB structure ID4DRJ
P638PDB structure ID1FAP
P638PDB structure ID4DRH
P638PDB structure ID4DRI
P638PDB structure ID4JSP
P638PDB structure ID5FLC
P638PDB structure ID1AUE
P638PDB structure ID2GAQ
P638PDB structure ID2NPU
P637RefSeq protein IDNP_004949
P637RefSeq protein IDXP_005263495
P637RefSeq protein IDXP_011539468
P637RefSeq protein IDXP_016856389
P637RefSeq protein IDXP_016856390
P637RefSeq protein IDXP_016856391
P637RefSeq protein IDXP_024301955
P352UniProt protein IDP42345

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